Musculoskeletal system disorder
MONDO:0002081A disease involving the musculoskeletal system.
Also known as: disease of musculoskeletal system, disease or disorder of musculoskeletal system, disorder of musculoskeletal system, musculoskeletal disease, musculoskeletal system disease, musculoskeletal system disease or disorder, musculoskeletal system disorder, musculoskeletal disorder
12041 clinical trials for this condition and its sub-types, 220 tagged with Musculoskeletal system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Musculoskeletal system disorder
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Skeletal system disorder 4 trials · 9,737 incl. sub-types
48 sub-types
- Bone disorder 53 trials · 6,305 incl. sub-types Sub-types →
- Arthropathy 139 trials · 3,208 incl. sub-types Sub-types →
- Bone marrow disorder 18 trials · 1,763 incl. sub-types Sub-types →
- Vertebral column disorder 82 trials · 1,243 incl. sub-types Sub-types →
- Periodontal disorder 303 trials · 982 incl. sub-types Sub-types →
- Tooth disorder 38 trials · 892 incl. sub-types Sub-types →
- Flatfoot 60 trials
- Patellar tendinitis 22 trials
- Marfan syndrome 21 trials Sub-types →
- Fibrodysplasia ossificans progressiva 10 trials
- Polydactyly 2 trials · 9 incl. sub-types Sub-types →
- Syndactyly 3 trials · 9 incl. sub-types Sub-types →
- Skeletal ligament disorder 0 trials · 7 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Coffin-Siris syndrome 1 trial Sub-types →
- Cartilage-hair hypoplasia 1 trial Sub-types →
- Cherubism 1 trial Sub-types →
- Ochronosis disorder 1 trial Sub-types →
- Ossification of the posterior longitudinal ligament of the spine 1 trial
- Primary basilar invagination 1 trial
- Short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome 1 trial
- Symphalangism 0 trials · 1 incl. sub-types Sub-types →
- Al-Gazali syndrome 0 trials
- Brachymorphism-onychodysplasia-dysphalangism syndrome 0 trials
- Buschke-Ollendorff syndrome 0 trials
- Rienhoff syndrome 0 trials
- Teebi-Shaltout syndrome 0 trials
- Anterior cranial fossa meningioma 0 trials Sub-types →
- Brachydactyly 0 trials Sub-types →
- Brachydactyly-syndactyly syndrome 0 trials
- Brachydactyly-syndactyly-oligodactyly syndrome 0 trials
- Cartilage cancer 0 trials
- Cartilage development disorder 0 trials
- Cranial nodular fasciitis 0 trials
- Endocrine-cerebro-osteodysplasia syndrome 0 trials
- Laryngeal cartilage cancer 0 trials
- Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria 0 trials
- Metaphyseal undermodeling, spondylar dysplasia, and overgrowth 0 trials
- Microcephaly-brachydactyly-kyphoscoliosis syndrome 0 trials
- Middle cranial fossa meningioma 0 trials Sub-types →
- Multiple congenital anomalies-hypotonia-seizures syndrome 3 0 trials
- Necrosis of ear ossicle 0 trials
- Posterior cranial fossa meningioma 0 trials Sub-types →
- Scalp defects-postaxial polydactyly syndrome 0 trials
- Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis 0 trials
- Skeletal tuberculosis 0 trials Sub-types →
- Sternal neoplasm 0 trials Sub-types →
- Temtamy preaxial brachydactyly syndrome 0 trials
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Muscle tissue disorder 58 trials · 2,427 incl. sub-types
13 sub-types
- Skeletal muscle disorder 11 trials · 1,366 incl. sub-types Sub-types →
- Cardiomyopathy 155 trials · 823 incl. sub-types Sub-types →
- Myomatous neoplasm 1 trial · 188 incl. sub-types Sub-types →
- Myalgic encephalomeyelitis/chronic fatigue syndrome 75 trials
- Conduction system disorder 8 trials · 46 incl. sub-types Sub-types →
- Myostatin-related muscle hypertrophy 10 trials
- Atrophic muscular disease 7 trials
- Distal arthrogryposis 0 trials · 3 incl. sub-types Sub-types →
- Kocher-debre-Semelaigne syndrome 0 trials
- Caveolinopathy 0 trials Sub-types →
- Septal myocardial infarction 0 trials
- Striated muscle rhabdoid tumor 0 trials
- Tonsillar pillar cancer 0 trials
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Musculoskeletal system cancer 2 trials · 1,970 incl. sub-types
11 sub-types
- Bone cancer 79 trials · 1,923 incl. sub-types Sub-types →
- Muscle cancer 0 trials · 72 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Synovium cancer 1 trial · 2 incl. sub-types Sub-types →
- Ameloblastic carcinoma 0 trials
- Broad ligament malignant neoplasm 0 trials Sub-types →
- Cartilage cancer 0 trials
- Laryngeal cartilage cancer 0 trials
- Round ligament malignant neoplasm 0 trials
- Tonsillar pillar cancer 0 trials
- Uterine ligament cancer 0 trials Sub-types →
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Autoimmune disorder of musculoskeletal system 0 trials · 797 incl. sub-types
3 sub-types
- Rheumatoid arthritis 578 trials · 797 incl. sub-types Sub-types →
- Autoimmune cardiomyopathy 0 trials Sub-types →
- Neonatal dermatomyositis 0 trials
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Musculoskeletal system benign neoplasm 0 trials · 224 incl. sub-types
8 sub-types
- Benign muscle neoplasm 4 trials · 118 incl. sub-types Sub-types →
- Benign connective and soft tissue neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Ameloblastoma 2 trials Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Benign neoplasm of sternum 0 trials
- Benign skeletal muscle neoplasm 0 trials
- Benign uterine ligament neoplasm 0 trials
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Disease of the tendon 126 trials · 192 incl. sub-types
3 sub-types
- Tendinitis 24 trials · 77 incl. sub-types Sub-types →
- Tendon sheath disorder 0 trials · 30 incl. sub-types Sub-types →
- Tendinosis 17 trials
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Synovium disorder 0 trials · 149 incl. sub-types
4 sub-types
- Synovial bursa disorder 0 trials · 119 incl. sub-types Sub-types →
- Synovium neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Synovitis 15 trials Sub-types →
- Synovial plica syndrome 1 trial
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Fasciitis 7 trials · 97 incl. sub-types
6 sub-types
- Plantar fasciitis 85 trials
- Necrotizing fasciitis 7 trials
- Eosinophilic fasciitis 1 trial
- Ischemic fasciitis 0 trials
- Nodular fasciitis 0 trials Sub-types →
- Proliferative fasciitis 0 trials
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Ligament disorder 8 trials · 15 incl. sub-types
4 sub-types
- Skeletal ligament disorder 0 trials · 7 incl. sub-types Sub-types →
- Disorder of uterine broad ligament 0 trials Sub-types →
- Round ligament malignant neoplasm 0 trials
- Uterine ligament neoplasm 0 trials Sub-types →
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Klippel-Feil syndrome 14 trials
6 sub-types
- Calabro syndrome 0 trials
- Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome 0 trials
- Klippel-Feil syndrome 1, autosomal dominant 0 trials
- Klippel-Feil syndrome 2, autosomal recessive 0 trials
- Klippel-Feil syndrome 3, autosomal dominant 0 trials
- Wildervanck syndrome 0 trials
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CINCA syndrome 4 trials
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Enthesopathy 2 trials · 4 incl. sub-types
5 sub-types
- Enthesitis 2 trials
- Fibular collateral ligament bursitis 0 trials
- Olecranon bursitis 0 trials
- Pes anserinus tendinitis or bursitis 0 trials
- Tibial collateral ligament bursitis 0 trials
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Ramon syndrome 0 trials
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Short stature, Dauber-Argente type 0 trials
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Upington disease 0 trials
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Auriculoosteodysplasia 0 trials
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Short stature, Brussels type 0 trials
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Synovial chondromatosis 0 trials
Most studied deeper sub-types
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New drug peresolimab tested for rheumatoid arthritis – study ends early
Disease control Stopped earlyThis study tested peresolimab, an experimental drug, in 491 adults with moderately-to-severely active rheumatoid arthritis who had not responded well to other treatments. The goal was to see if peresolimab could reduce joint pain and swelling better than a placebo. However, the s…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Experimental drug losmapimod tested in rare muscle disease – early hopes, but trial cut short
Disease control Stopped earlyThis study tested an experimental drug called losmapimod in 14 adults with FSHD1, a rare genetic condition that causes progressive muscle weakness. The main goal was to check safety and tolerability, and to see if the drug affects certain biological markers. The trial was termina…
Phase 2 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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FSHD drug trial halted midway: what happened?
Disease control Stopped earlyThis study tested a drug called losmapimod for people with a rare muscle-weakening disease called FSHD. The goal was to see if the drug could slow muscle loss and improve arm function over 48 weeks. About 260 adults with FSHD were randomly assigned to receive either losmapimod or…
Phase 3 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Experimental drug losmapimod tested for rare muscle disease
Disease control Stopped earlyThis phase 2 trial tested the drug losmapimod in 76 adults with FSHD, a genetic condition that causes progressive muscle weakness. Participants took either losmapimod or a placebo for 48 weeks to see if the drug was safe and could help control the disease. The study was terminate…
Phase 2 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Could a cheap arthritis drug replace steroids for transplant complications?
Disease control Stopped earlyThis study tested leflunomide, a drug used for rheumatoid arthritis, as a first-line treatment for musculoskeletal graft-versus-host disease (GVHD), a complication of bone marrow transplants where donor cells attack the patient's muscles and joints. The goal was to see if lefluno…
Phase 2 • Sponsor: Tata Memorial Centre • Aim: Disease control
Last updated Jun 26, 2026 15:35 UTC
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New drug aimed at easing knee pain fails to finish trial
Symptom relief Stopped earlyThis study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Diet and exercise study for overweight women halted early
Knowledge-focused Stopped earlyThis study looked at whether an 8-week diet program, with or without aerobic and resistance exercise, could improve balance, muscle pain, physical function, and sleep in overweight women aged 18-50. The trial was terminated early, so results are limited. It was designed to gather…
Sponsor: Bezmialem Vakif University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Scientists gather leftover surgical tissue to unlock secrets of bone disease
Knowledge-focused Stopped earlyThis study collected bone, cartilage, skin, and fat tissue from 50 patients undergoing surgery at Children's National Medical Center. The goal was to grow cells from these tissues in the lab and analyze them to better understand bone and connective tissue diseases. The study was …
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC