Hope for FSHD: experimental drug losmapimod tested in major trial

NCT ID NCT05397470

Terminated Disease control Sponsor: Fulcrum Therapeutics Source: ClinicalTrials.gov ↗

First seen Nov 11, 2025 · Last updated May 11, 2026 · Updated 16 times

Summary

This study tested a drug called losmapimod in 260 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. Participants took either the drug or a placebo for 48 weeks to see if it could slow muscle decline. The trial was terminated early, but the results help researchers understand the drug's safety and effects on arm function.

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Contacts and locations

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Locations

Aarhus Universitetshospital

Aarhus, 8200, Denmark
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Fondazione Serena Onlus- Centro Clinico NEMO

Milan, Lombardy, 20162, Italy
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario Donostia

San Sebastián, Guipuzkoa, 20014, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Institute de Myologie, Groupe Hospitalier Pitié-Salpêtrière

Paris, 75013, France
Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States
LMU Klinikum Ludwig-Maximilians-Universität München

München, 80336, Germany
Leiden University Medical Centre

Leiden, Southern Holland, 2333 ZA, Netherlands
Mayo Clinic

Rochester, Minnesota, 55905, United States
Montreal Neurological Institute and Hospital

Montreal, Quebec, H3A 2B4, Canada
Newcastle upon Tyne NHS Foundation Trust

Newcastle upon Tyne, NE1 3BZ, United Kingdom
Nice University Hospital - CHU Nice

Nice, PACA, 06001, France
Ohio State University Medical Center

Columbus, Ohio, 43210, United States
Radboudumc

Nijmegen, Gelderland, 9101, Netherlands
Rigshospitalet

Copenhagen, 2100, Denmark
The Ottawa Hospital Research Institute

Ottawa, Ontario, K1Y 4E9, Canada
University College of London Hospitals

London, WC1N 3BG, United Kingdom
University Hospital Bonn

Bonn, 53127, Germany
University of Calgary

Calgary, Alberta, T2N 4Z6, Canada
University of California Irvine

Irvine, California, 92868, United States
University of California Los Angeles (UCLA)

Los Angeles, California, 90095, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Massachusetts Memorial Medical Center

Worcester, Massachusetts, 01655, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Utah

Salt Lake City, Utah, 84132, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Universitätsklinikum Ulm

Ulm, 89081, Germany
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD)