Muscular atrophy

This study tests a gene therapy designed to help older adults regain muscle mass and strength lost with age. The treatment uses a harmless virus to deliver a gene that promotes muscle growth, sometimes combined with another gene that improves blood flow. The trial involves 12 par…

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This phase 2 trial tests whether a 4-week course of an essential amino acid supplement can help older adults (65+) rebuild muscle after a hip fracture. Sixty participants will be randomly assigned to receive either the supplement or standard care alone. Researchers will measure m…

This study tests whether giving ICU patients extra protein and activating their muscles early (using electrical stimulation and movement) can prevent severe muscle loss. About 40 critically ill adults on ventilators will take part. The goal is to see if this approach helps patien…

This study tests whether a drug called ACM-001.1 can help obese people keep their muscle while taking semaglutide for weight loss, and help them regain muscle after stopping semaglutide. About 120 participants will receive either ACM-001.1 or a placebo alongside semaglutide, and …

This study tests whether taking whey protein and collagen supplements along with doing resistance exercises can help people keep their muscle mass after bariatric surgery. About 35 adults who are having the surgery will be split into groups to compare different combinations of su…

This early-stage study tests whether metformin, a widely used diabetes medication, can improve muscle regrowth in older adults after a period of inactivity (like bed rest). Fifty volunteers aged 60 and older will receive either metformin or a placebo during recovery. The goal is …

This study looks at whether adding protein supplements to the diet can prevent muscle wasting in people with heart failure. About 120 adults with heart failure and reduced pumping ability will be randomly assigned to receive no, low, or high doses of protein drinks. The main goal…

This early-phase trial tests a new drug called IMM01-STEM, made from stem cell secretions, in 28 people with muscle wasting due to knee osteoarthritis. The main goal is to check safety and find the right dose. Participants receive injections and are monitored for side effects ove…

This study is testing a handheld device called mScan that uses a tiny, painless electrical current to measure muscle health. Researchers want to see if it can give similar results to an MRI, but faster and more conveniently. The study involves 150 adults with and without muscle d…

This study tests whether wearing a smartwatch that tracks activity and body composition, along with exercise reminders, can help people on GLP-1 drugs (like Ozempic or Wegovy) maintain muscle and strength. About 100 adults who recently started or plan to start these medications w…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study looks at two different exercise programs—using flexi bands or whole-body electrical stimulation—for people with cancer. The goal is to see which one better helps maintain muscle strength, reduce inflammation, and improve quality of life during treatment. About 100 part…

This study looks at whether adding blood flow restriction training (BFRT) to standard physical therapy helps teens recover strength and muscle size after ACL reconstruction. Forty teens who played sports before surgery will be randomly assigned to either standard rehab or standar…

This study uses ultrasound to measure muscle, fat, and fluid changes in 121 critically ill pregnant or gynecological patients in the ICU. The goal is to see if these body composition changes are linked to serious outcomes like death, need for a breathing machine, or longer hospit…

This study tests whether adding servo-assisted bed cycling to standard physical therapy can reduce muscle breakdown in critically ill patients with sepsis. Researchers will measure inflammation and muscle damage markers in 24 participants over 7 days. The goal is to understand if…

This study tests whether taking dietary nitrate (found in beets) can help prevent muscle loss and weakness when a leg is immobilized in a brace for 14 days. Researchers will measure muscle function and energy use in 24 healthy young men. The goal is to find a simple, drug-free wa…

This study looks at whether simple measurements—like thigh circumference and muscle stiffness—can reliably track muscle health in people with COPD. Researchers will measure 30 patients before and after a pulmonary rehabilitation program. The goal is to find an easy way to monitor…

This study aims to find better ways to measure fatigue and walking problems in people with neuromuscular diseases like muscular dystrophy and spinal muscular atrophy. Researchers will use a wearable sensor to track physical activity for one week in daily life and during a walking…

This study aims to understand how muscle health recovers after a period of disuse, like being in a cast. Researchers will immobilize one leg of healthy volunteers for two weeks, then measure muscle size and strength before and after. The study includes both younger (18-35) and ol…

This study looks at how muscle wasting in the mouth and throat affects swallowing in adults who are critically ill and in the intensive care unit. Researchers will measure muscle size and strength, and test swallowing safety at several points during the hospital stay. The goal is…

This study tests whether a type of exercise using a flywheel machine can help prevent muscle loss and weakness during space travel. Sixteen healthy adults who exercise regularly will take part. They will use crutches and a special shoe to mimic the reduced weight-bearing of space…

This study looks at what happens to muscle size, strength, and insulin sensitivity after 5 days of strict bedrest in healthy young adults. Twelve volunteers will undergo tests before and after the bedrest period, including MRI scans, strength tests, and muscle biopsies. The goal …

This study tests whether taking 20 or 40 grams of whey protein can help prevent muscle loss when a leg is immobilized in a knee brace. Researchers will measure how well muscles build protein in 28 healthy adults. The goal is to find the best protein dose to keep muscles strong du…