Diabetic neuropathy

This trial compares three approaches for treating painful diabetic neuropathy: oral medications, topical treatments, and cognitive behavioral therapy. Researchers will enroll 600 adults with diabetes and nerve pain, randomly assigning them to one of these options for four months.…

This trial aims to find out whether a standard exercise program (Otago) or a specialized balance training that engages multiple senses (multisensory integration) is more effective at improving balance and walking in older adults with type 2 diabetes. Participants, aged 65 to 75, …

This trial tests whether a traditional Chinese herbal formula, Zuogui Jiangtang Shuluo, can improve nerve function and reduce symptoms in people with diabetic peripheral neuropathy, a common complication of type 2 diabetes that causes pain, numbness, and tingling. Participants wi…

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This study compares two types of balance training for people with diabetic neuropathy, a condition that can cause numbness and balance problems. 42 participants will be randomly assigned to do balance exercises on a firm surface or on a rolling board, three times a week for four …

This study tests whether eating four GlucoBites cookies daily for 12 weeks can improve blood sugar control and reduce the risk of diabetic foot ulcers in adults with type 2 diabetes. The cookies contain an herb called Gynura procumbens. Researchers will compare blood sugar, insul…

This study looks at how well nerve tests and ultrasound can detect diabetic peripheral neuropathy, a common complication of diabetes that causes pain and numbness in the feet. Researchers will compare results from 75 adults with diabetes and healthy volunteers to see which tests …

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This trial tests whether a lower dose of duloxetine combined with alpha-lipoic acid can relieve painful diabetic peripheral neuropathy as effectively as the standard higher dose of duloxetine alone. Adults with diabetes and nerve pain will be randomly assigned to one of the two t…

This study tests whether acupressure—a non-invasive therapy using finger pressure on specific body points—can reduce nerve pain, improve balance confidence, and lessen fear of falling in adults aged 65+ with painful diabetic peripheral neuropathy. 76 participants will be randomly…

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This study tests whether adding pain neuroscience education — simple lessons and metaphors about how pain works — to nerve mobilization exercises provides more relief than exercises alone. About 40 adults with type 2 diabetes and long-term leg nerve pain will be randomly assigned…

This study tests whether a supplement called DLBS1033, made from earthworm extract, can improve nerve function and reduce symptoms in people with diabetic neuropathy. Participants take either the supplement or a placebo alongside their usual treatment for 12 weeks. Researchers me…

This study tests whether a structured program of touch, temperature, vibration, and movement exercises can improve sensation and hand function in people with diabetic peripheral neuropathy. Fifty-nine adults with stable diabetes will be randomly assigned to either the active trai…

This study tests whether combining a gentle electrical stimulation of the spinal cord with augmented reality exercises can improve quality of life and physical activity in people with diabetic neuropathy. About 36 adults with nerve pain will receive the treatment and be followed …

This study tests whether combining a mild electrical stimulation of the spinal cord (tSCS) with augmented reality (AR) exercises can reduce pain and improve balance in people with diabetic neuropathy. About 36 adults with moderate to severe nerve pain will receive the combined tr…

This study will compare two exercise programs—the Otago program and the Beat It program—in 32 people with type 2 diabetes and nerve damage in their feet. The goal is to see which program better improves balance, walking, and quality of life. Participants will do exercises 4 times…

This study will compare two exercise programs—qigong (a gentle movement practice) and Otago (a standard balance and strength program)—in 44 adults with diabetic neuropathy (nerve damage from diabetes). The goal is to see which one better improves agility, balance, walking, and qu…

This study tests whether low-frequency electroacupuncture can reduce pain and numbness in people with diabetic peripheral neuropathy (DPN). 92 adults with DPN will receive either real or sham electroacupuncture for 6 weeks. Researchers will measure nerve function, pain levels, an…

This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…

This study tests whether a dietary supplement called Cronilief (palmitoylethanolamide) can reduce nerve pain in people with diabetes when added to their usual treatment. Seventy adults with moderate nerve pain will take either the supplement or a placebo for 8 weeks. The goal is …

This study compares two types of exercise programs—Modified Otago Exercises and Dynamic Neuromuscular Stabilization Exercises—to see which better improves balance and daily living activities in older adults with diabetic peripheral neuropathy. The trial will involve 36 participan…

This study looks at whether doing foot and ankle exercises at home can help people with diabetic nerve pain feel better. The exercises are done twice a day, three days a week, for eight weeks. Researchers will measure pain, sleep quality, and depression in 70 adults with diabetic…

This study tests whether aromatherapy foot massage can reduce neuropathic pain in people with type 2 diabetes. 78 participants will massage their feet for 10 minutes, three times a week for 4 weeks. Researchers will compare the effects of an aromatherapy oil versus a plain oil to…

This study tests whether doing exercises in a heated pool (hydrotherapy) can reduce pain, improve balance, and boost quality of life for people with diabetic peripheral neuropathy. Thirty-four adults with type 2 diabetes and nerve damage will be randomly assigned to either hydrot…

This study tests whether a 12-week exercise program that works the trunk, hips, knees, and ankles can reduce symptoms and improve quality of life in people with diabetic peripheral neuropathy. Sixty-four adults with type 2 diabetes and nerve damage will be randomly assigned to ei…

This Phase 2 trial tests an experimental oral drug called HL-1186 for diabetic peripheral neuropathic pain—a common, painful nerve condition caused by diabetes. About 180 adults with type 1 or type 2 diabetes will receive either HL-1186 or a placebo for 12 weeks. The main goal is…

This study investigates whether targeted electrical stimulation of peripheral nerves can improve blood flow and blood vessel function in the lower limbs of veterans with diabetic peripheral neuropathy. Researchers will measure skin blood flow, vessel density, and oxygen levels us…

This study investigates whether blood levels of irisin, a protein linked to glucose metabolism and nerve protection, differ in people with type 2 diabetes who have diabetic polyneuropathy (nerve damage) compared to those without it and healthy controls. Researchers will measure i…

This study looks at whether a painless ultrasound scan of the sciatic nerve and a blood test for a specific protein can help detect diabetic peripheral neuropathy (nerve damage) earlier than current methods. Researchers will measure nerve size and blood flow in 120 people with ty…

This study looks at whether the way health information is presented can help people with diabetes better understand their risk of developing foot ulcers. Researchers will compare two types of messages—one focusing on the benefits of good foot care, the other on the risks of negle…

This study will analyze blood samples from 90 people — 30 healthy, 30 with diabetes but no nerve issues, and 30 with diabetic peripheral neuropathy (nerve damage causing pain). Researchers will look for unique molecules in the blood that could serve as early warning signs. The go…

This study looks at how diabetic polyneuropathy (nerve damage from diabetes) changes responses to common dental pulp tests like electric and cold stimuli. Researchers will compare people with mild neuropathy, severe neuropathy, and healthy controls to see if nerve damage leads to…

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study will measure vitamin D and nerve growth factor levels in 57 men with type 2 diabetes and nerve damage, comparing them to diabetic men without nerve damage and healthy men. Researchers will also test nerve function using electrical studies. The goal is to see if low vit…

This study will follow 460 diabetes patients who take semaglutide to see if those with nerve damage (neuropathy) are more likely to develop stomach retention, where food stays in the stomach too long. Participants will have a stomach exam to check for retained food or liquid. The…