Conjunctivitis

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study compares two approved cyclosporine eye drops—Vevye (0.1%) and a generic (0.05%)—in 60 adults with dry eye disease. Over 8 weeks, researchers will measure changes in goblet cells, which produce mucus to keep eyes moist. Participants use drops daily and visit the clinic …

This Phase 3 trial tests whether a disc made from donated human amnion membrane can help people with moderate to severe dry eye disease. The disc is placed on the eye and compared to standard care like lubricating drops and a bandage lens. The study will enroll 40 adults who have…

This study tests whether injecting stem cells into the eye can help people with severe dry eye caused by graft-versus-host disease (GVHD), a complication of bone marrow transplants. The trial will include 30 adults who have not improved with standard treatments. Participants will…

This study aims to create an artificial intelligence system that can automatically analyze confocal microscopy images of the cornea to diagnose dry eye disease. Researchers will collect eye scans from 75 adults (healthy and with dry eye) to train and test the AI. The goal is to r…

This study tests a small device that attaches to a smartphone to help diagnose dry eye disease. It takes special pictures of the eye's surface using different lights. The goal is to see if people can use it at home to get accurate results, compared to a standard eye exam. About 5…

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study compares a new eye drop (perfluorohexyloctane) with a standard one (sodium hyaluronate) for people whose eyes get dry from using screens for more than 6 hours a day. Participants aged 18 to 70 with mild to moderate dry eye will use the drops four times daily for 8 week…

This study tests whether two experimental antibodies, given alone or together, can reduce eye allergy symptoms caused by cat dander. About 570 adults and children aged 8 and older with confirmed cat allergy will receive either the antibodies or a placebo. The main goal is to see …

This study tests whether acoltremon eye drops can improve symptoms and tear production in people with dry eye disease over 12 months. Sixty adults will be randomly assigned to receive either the active drug or a standard artificial tear. Researchers will track changes in eye disc…

This study looks at whether a gel-like filler placed in the tear ducts can improve dry eye symptoms and make eye measurements more accurate before cataract surgery. About 65 adults with dry eye disease will be observed. The goal is to see if treating dry eye first leads to better…

This study compares two types of artificial tears for dry eye disease: one with preservatives and one without. Researchers want to see which is safer and more effective over 8 weeks. About 80 adults with dry eye will take part, and neither they nor their doctors will know which t…

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study compares a new eyelid support plate to a standard glass rod for eyelid massage in people with dry eye from meibomian gland dysfunction. 142 adults will receive either the new device or standard massage, plus eye drops, over 8 weeks. The goal is to see which method bett…

This study tests an experimental eye drop called RCI001 in 200 adults with dry eye disease. Participants will use the drops or a placebo for 4 weeks. The goal is to see if RCI001 reduces eye discomfort and damage to the eye's surface better than placebo. The study is not yet recr…

This study tests a device called TearCare that warms the eyelids and manually clears blocked oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. T…

This small study tests whether a special VR headset, called Lacrima VR, can improve dry eye symptoms in people with dry eye disease and meibomian gland dysfunction. Twenty adults will either get the active treatment (light pulses through the headset) or a sham version with dimmer…

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study tests whether simply taping the eyelids shut during general anesthesia is enough to protect the cornea, or if adding lubricant eye drops is better. Two hundred adults having non-eye surgery will be randomly assigned to one of the two methods. The main goal is to see ho…

This study tests whether a structured blinking exercise can improve dry eye symptoms in adults with glaucoma who use eye drops. 45 participants will perform 15 close-squeeze-open blinks three times daily for two weeks. Researchers will measure symptom changes and tear film stabil…

This study tests lifitegrast eye drops (Xiidra) in 30 adults with dry eye disease. Researchers will use a special microscope to see if the drops reduce immune cells on the eye surface. The goal is to ease dry eye symptoms and understand how the treatment works.

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This early-stage study tests whether a new eye ointment called RC017 is safe and tolerable in 24 healthy adults aged 18 to 55. The ointment is being developed to treat dry eye disease. Participants will receive either the ointment or a placebo, and researchers will monitor for si…

This study compares two behavioral interventions—Baduanjin (a gentle 10-15 minute exercise) or laughter exercises using a smartphone app—plus artificial tears, against artificial tears alone for treating dry eye disease. About 540 adults aged 18-45 with moderate dry eye will part…

This study will test perfluorohexyloctane eye drops, the only approved drug in China for dry eye disease related to meibomian gland dysfunction. Researchers plan to enroll 2000 adults and track their symptoms, eye health, and any side effects over 12 weeks. The goal is to see how…

This study tests a blink reminder program called 'BlinkEasy' in 28 adults aged 18–40 who use screens at least 4 hours a day and have dry eye symptoms. Over three months, researchers will measure if the app slows the loss of oil glands in the eyelids and improves eye comfort. Part…

This study compares two common eye drops—rebamipide and diquafosol—for managing dry eye in people having cataract surgery. Sixty adults with mild to moderate dry eye will use one of the drops four times a day, starting one month before surgery and continuing for three months afte…

This study tests whether VMX eye drops can improve tear film stability and reduce dry eye symptoms compared to standard care. About 76 adults with mild to moderate dry eye disease will receive either VMX drops or a control. The main goal is to see if the drops help eyes stay mois…

This study tests acoltremon eye drops in 60 adults with dry eye disease to see if they improve symptoms like discomfort and blurry vision. Participants will complete surveys over three months to track changes. The goal is to understand how well the drops work in everyday life for…

This study tests whether eyedrops made from Kelulut honey (from stingless bees) are safe and can ease dry eye symptoms. 45 adults will use one of three strengths of honey drops three times a day for a month, while continuing their usual treatments. Researchers will check tear sta…

This study tests whether switching from Restasis to a new eye drop called acoltremon 0.003% can better relieve dry eye symptoms and improve tear production. About 100 adults with chronic dry eye who are dissatisfied with Restasis will take part. Researchers will measure changes i…

This study looks at whether switching from the dry eye drop Xiidra to a new drop called TRYPTYR (acoltremon 0.003%) can improve symptoms and tear production. About 100 adults with chronic dry eye who are already using Xiidra will take part. Researchers will measure tear productio…

This study tests a new eye drop called BRM421 against standard artificial tears in 99 adults with dry eye disease. The goal is to see if BRM421 is safe and better at reducing eye damage and discomfort. Participants will use the drops for 6 weeks, and doctors will measure changes …

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study looks at whether dry eye disease makes it harder to calculate the right lens power for cataract surgery. Researchers will compare 100 patients with and without dry eye to see if those with dry eye have less accurate lens measurements. The goal is to find out if treatin…

This study looks at how blinking behavior is linked to the stability of the tear film in adults aged 18 to 65, both with and without dry eye symptoms. Participants will answer a questionnaire, have their vision checked, and undergo non-invasive tear film measurements using an ima…

This study will measure changes in tear fluid proteins in 36 adults with dry eye disease who are already using lifitegrast (Xiidra) eye drops. Researchers want to see how the drug affects these biomarkers over 84 days. The goal is to better understand dry eye and how the treatmen…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study compares how two types of sedation affect tear production in 52 adults undergoing angioplasty. One group gets dexmedetomidine, the other gets standard sedatives like midazolam and fentanyl. Tear production is measured before, right after, and 12 hours after the procedu…

This study examines immune cells in 60 people with allergic conjunctivitis, both those receiving desensitization therapy and those not, plus healthy controls. Researchers will analyze blood and tear samples to measure specific immune markers and cell activity. The goal is to find…