Cerebral arterial disease

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This study will test a special coil called the Penumbra PC400 in 100 adults aged 18 to 80 who have a medium or large brain aneurysm (5 mm or bigger). The coil is placed inside the aneurysm to block blood flow and prevent rupture or rebleeding. Researchers will track how well the …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study compares a newer flow-diverting stent to standard stent-assisted coiling for treating unruptured brain aneurysms in the middle cerebral artery. About 140 adults aged 18-70 will be randomly assigned to one of the two procedures. The main goal is to see which method more…

This study tests whether a short course of the steroid methylprednisolone can reduce the risk of stroke or death within 30 days after a flow-diverter stent is placed to treat an unruptured brain aneurysm. About 864 adults will be randomly assigned to receive either the steroid or…

This study tests a device called the World Diverter, which is placed inside blood vessels to block blood flow to brain aneurysms (weak spots in artery walls). The goal is to safely seal the aneurysm and prevent rupture. About 72 adults aged 22–80 with unruptured aneurysms in a sp…

This study tests whether adding a traditional Chinese herbal formula (Qiqi Shengmai) to standard care can improve blood flow in the brains of people with moyamoya disease. About 66 adults aged 18 to 80 will receive either the herbal formula or a placebo for a set period. The goal…

This early study will test a new device called the LuSeed Aneurysm Embolization System in 10 people with unruptured brain aneurysms. The device is designed to block blood flow to the aneurysm, reducing the risk of rupture. The main goals are to see if the device is safe and can b…

This study tests a device called a flow diverter to treat brain aneurysms that are not balloon-shaped. The goal is to block blood flow into the aneurysm, helping it heal and preventing rupture. About 168 adults aged 18 to 80 will be enrolled, and the main outcome is complete bloc…

This study tests a new type of ultrasound that can see through the skull to find tiny metal pieces left after brain aneurysm surgery. About 78 adults who had aneurysm clipping will get this ultrasound within 3 hours after surgery, along with a standard CT scan. The goal is to see…

This study tests whether giving a calcium channel blocker (nicardipine) through a lumbar drain can prevent dangerous artery spasms and delayed brain damage in people who have had a brain bleed from a ruptured aneurysm. About 214 adults with mild to moderate bleeds will receive th…

This study tests a new approach to prevent delirium (sudden confusion) in patients with a type of stroke called subarachnoid hemorrhage who are in the intensive care unit. The program combines standard medical care with basic body awareness therapy and video-based communication. …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study looks at whether an AI-based tool that helps doctors shape a microcatheter can improve the safety and success of coil embolization, a procedure to treat brain aneurysms. Researchers will follow about 1,400 adults who are scheduled for this procedure, comparing cases wh…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study looks at whether using a 3D-printed copy of a patient's brain aneurysm can help doctors plan treatment and avoid problems. About 40 adults with unruptured aneurysms will have their aneurysm printed from scans, then doctors will practice the procedure on the model befor…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study tests a digital platform called GetReady that helps doctors and patients track brain aneurysm follow-up data, including symptoms and quality of life. About 200 people with brain aneurysms will use the platform during routine care. The goal is to see if it improves heal…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study looks at whether people who have had a ruptured brain aneurysm also have an abdominal aortic aneurysm (a bulge in the main belly artery) that they don't know about. About 233 participants will get a painless belly ultrasound to check. The goal is to see how common this…

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study watches brain oxygen levels and anesthesia depth in 75 adults during a procedure to fix a brain aneurysm. The goal is to see how these measurements relate to each other and to vital signs like blood pressure. No extra treatments are given—just careful observation to he…

This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory respon…

This observational study will follow 630 people with cerebral arteriovenous malformations (AVMs) and intracranial aneurysms to learn how these conditions progress and how different treatments perform. Researchers will track imaging success rates and complications over time. The g…

This study observes 100 patients having elective brain surgery to clip an aneurysm. Some take daily low-dose aspirin, others do not. Researchers track bleeding during surgery and on CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or …

This study tests whether using less contrast dye during brain scans for unruptured aneurysms can still produce clear images. About 244 adults will be randomly assigned to receive either the standard dye amount or a reduced amount. The goal is to find a safer, more comfortable way…