Carpal tunnel syndrome

This study looks for early signs of a heart condition called cardiac amyloidosis in people who have had carpal tunnel surgery on both hands. Researchers will use a special heart scan to check for abnormal protein buildup. The goal is to find the disease earlier so treatment can s…

This study looks at whether a person's body weight affects the accuracy of ultrasound for diagnosing carpal tunnel syndrome. Researchers will measure the median nerve size with ultrasound and compare it to standard nerve tests in 120 adults. The goal is to see if weight 'masks' t…

This study aims to translate and test a diagnostic tool called CTS-6 for Turkish-speaking patients with carpal tunnel syndrome. Researchers will enroll 126 adults, including healthy volunteers, people with symptoms, and those already diagnosed. The goal is to ensure the tool is a…

This study tests whether TECAR therapy, a device that uses radiofrequency energy to heat tissues, can reduce pain and improve hand function in people with carpal tunnel syndrome after a burn. Fifty-two adults aged 20 to 40 with mild to moderate carpal tunnel and a history of uppe…

This study investigates whether matrix rhythm therapy, a device that delivers gentle vibrations to the hand and arm, can reduce symptom severity and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Participants receive either active or sham therapy tw…

This study tests if a combination of manual therapy and nerve stimulation can relieve symptoms of moderate carpal tunnel syndrome as well as surgery recovery does. About 150 adults aged 30-50 with confirmed moderate carpal tunnel will be split into two groups: one gets the non-su…

This study compares a minimally invasive ultrasound-guided injection to standard open surgery for carpal tunnel syndrome. 72 adults who have not improved with conservative treatments will be randomly assigned to receive either the injection or surgery. The main goal is to see if …

This pilot study will test whether a device that sends magnetic pulses to the arm can reduce pain in people with tennis elbow, golfer's elbow, or carpal tunnel syndrome. About 40 adults will receive either real or fake (sham) stimulation over two days. Researchers will measure pa…

This study will compare three different injections—glucocorticoid, ozone, and 5% dextrose—to see which provides the best pain relief for people with mild to moderate carpal tunnel syndrome. Researchers will enroll 105 adults aged 18 to 65 who have not responded to conservative tr…

This study tests whether hyaluronic acid injections work as well as standard steroid shots for mild to moderate carpal tunnel syndrome. Sixty adults will receive one type of injection under ultrasound guidance, and researchers will track symptom changes and nerve function for thr…

This study compares three different wrist splint positions (flexed, neutral, and extended) worn at night for eight weeks in 108 adults with mild to moderate carpal tunnel syndrome. All participants also receive education and exercises. The goal is to see which position best reduc…

This study tests whether low-frequency magnetic field therapy (magnetotherapy) can reduce pain and improve function in people with mild-to-moderate carpal tunnel syndrome. Sixty adults will be randomly assigned to receive either active magnetotherapy, a placebo device, or standar…

This study looks at whether laser acupuncture can help reduce carpal tunnel syndrome symptoms in breast cancer patients who take aromatase inhibitors. Fifty-four women aged 40-60 will be split into two groups: one gets laser acupuncture plus standard physical therapy, the other g…

This study tests whether 4-aminopyridine, a drug already approved for other nerve conditions, can improve symptoms of carpal tunnel syndrome or delay the need for surgery. Researchers will give 160 adults either the drug or a placebo for 6 weeks and track symptom changes using ha…

This study looks at whether adding special hand exercises (nerve gliding or bone mobilization) to a standard wrist splint helps people with mild-to-moderate carpal tunnel syndrome more than using the splint alone. About 93 adults will be assigned to one of three groups and treate…

This study looks at whether leaving out bicarbonate from the numbing medicine (lidocaine with adrenaline) affects how well people recover the day after hand or foot surgery. About 150 adults having common procedures like carpal tunnel release or bunion surgery will be randomly as…

This study tests whether a non-invasive magnetic stimulation device (rPMS) can reduce pain and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Forty participants will receive either real or sham stimulation plus standard exercises over two weeks. Res…

This study tests whether injecting a larger or smaller amount of fluid around the median nerve in the wrist better relieves pain from carpal tunnel syndrome. 35 adults with mild to moderate carpal tunnel will receive either 8 ml or 3 ml of dextrose, or a steroid injection. The go…

This study compares two minimally invasive treatments for carpal tunnel syndrome: pulsed radiofrequency (using heat pulses) and hyaluronidase hydrodissection (injecting a fluid to free the nerve). About 56 adults with mild to moderate carpal tunnel will be randomly assigned to on…

This study tests whether dipping the hand and forearm in warm paraffin wax for 20 minutes can immediately reduce muscle stiffness and pain in people with carpal tunnel syndrome. Twenty-four adults with the condition will be randomly assigned to either the wax treatment or rest. R…

This study looks at whether a single 20-minute warm whirlpool bath can quickly reduce muscle stiffness and pain in the forearm and hand for people with carpal tunnel syndrome. About 24 adults with the condition will either take the bath or rest. Researchers will measure muscle st…

This study tests whether taking N-acetylcysteine (NAC), a common supplement, before and after hand or foot surgery can reduce pain and the need for opioid painkillers. About 80 adults will be randomly assigned to take NAC or a placebo for 14 days. Researchers will track pain, fun…

This study tests whether carpal tunnel release surgery actually works better than a placebo surgery for carpal tunnel syndrome. 96 adults with confirmed CTS will be randomly assigned to real surgery or a sham procedure, and neither they nor their doctors will know which they rece…

This study will test blood samples from 450 people aged 6 to 60 with inherited neuromuscular diseases to see if they have antibodies that could block gene therapy viruses (AAVs). The goal is to understand how common these antibodies are and which patients might be good candidates…

This study follows 60 adults with hand or upper limb injuries to see if improvements in the first weeks of rehab can predict function months later. A digital tool created by a therapist tracks progress and patient feedback. The goal is to help clinicians make better, data-driven …

This study uses ultrasound to measure the size and blood flow of the median nerve in people with carpal tunnel syndrome. Researchers will compare findings between diabetic and non-diabetic patients to see if diabetes affects nerve changes. The goal is to better understand the con…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…