Bone disorder
MONDO:0005381Diseases of bones.
Also known as: bone element disease, bone element disease or disorder, disease of bone element, disease or disorder of bone element, disorder of bone element, rare bone disease related to a common gene or pathway defect
6290 clinical trials for this condition and its sub-types, 53 tagged with Bone disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Bone disorder
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Bone inflammation disease 1 trial · 2,667 incl. sub-types
6 sub-types
- Arthritic joint disease 194 trials · 2,548 incl. sub-types Sub-types →
- Epicondylitis 86 trials
- Osteomyelitis 43 trials · 46 incl. sub-types Sub-types →
- Osgood-Schlatter disease 5 trials
- Mastoiditis 1 trial
- Caffey disease 0 trials
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Bone neoplasm 26 trials · 2,116 incl. sub-types
20 sub-types
- Bone cancer 79 trials · 1,921 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Bone benign neoplasm 1 trial · 70 incl. sub-types Sub-types →
- Notochordal tumor 0 trials · 34 incl. sub-types Sub-types →
- Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone 0 trials · 7 incl. sub-types Sub-types →
- Solitary bone cyst 6 trials
- Vascular bone neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Hereditary multiple osteochondromas 3 trials Sub-types →
- Hyperparathyroidism 2 with jaw tumors 1 trial
- Neonatal severe primary hyperparathyroidism 1 trial
- Neoplasm of femur 0 trials · 1 incl. sub-types Sub-types →
- OSLAM syndrome 0 trials
- Aneurysmal bone cyst 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Hyperparathyroidism 1 0 trials
- Hyperparathyroidism 3 0 trials
- Hyperparathyroidism 4 0 trials
- Juvenile hyaline fibromatosis 0 trials
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Skeletal dysplasia 1 trial · 660 incl. sub-types
119 sub-types
- Osteochondrodysplasia 12 trials · 380 incl. sub-types Sub-types →
- Lysosomal storage disease with skeletal involvement 0 trials · 63 incl. sub-types Sub-types →
- Chondrodysplasia punctata 0 trials · 39 incl. sub-types Sub-types →
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- Non-syndromic limb reduction defect 0 trials · 35 incl. sub-types Sub-types →
- FGFR3-related chondrodysplasia 0 trials · 33 incl. sub-types Sub-types →
- Abnormal mineralization disorder 0 trials · 22 incl. sub-types Sub-types →
- Syndromic craniosynostosis 1 trial · 22 incl. sub-types Sub-types →
- Osteopetrosis 6 trials · 14 incl. sub-types Sub-types →
- Amniotic band syndrome 8 trials · 9 incl. sub-types Sub-types →
- Primordial dwarfism and slender bone disorder 0 trials · 9 incl. sub-types Sub-types →
- Acromelic dysplasia 0 trials · 8 incl. sub-types Sub-types →
- Polydactyly-syndactyly-triphalangism 0 trials · 6 incl. sub-types Sub-types →
- McCune-Albright syndrome 5 trials
- SHOX-related short stature 5 trials
- Primary osteolysis 0 trials · 5 incl. sub-types Sub-types →
- Filamin-related bone disorder 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Proteus syndrome 2 trials
- SLC26A2-related skeletal dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Acheiria 0 trials · 2 incl. sub-types Sub-types →
- Bent bone dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Congenital absence of both forearm and hand 1 trial · 2 incl. sub-types Sub-types →
- Metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome 2 trials
- Short rib dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Spondylodysplastic dysplasia 0 trials · 2 incl. sub-types Sub-types →
- 2q37 microdeletion syndrome 1 trial
- COMP-related skeletal dysplasia 0 trials · 1 incl. sub-types Sub-types →
- Currarino triad 1 trial
- Sotos syndrome 1 trial
- Chondromalacia patellae 1 trial
- Coxopodopatellar syndrome 1 trial
- Craniofrontonasal syndrome 1 trial
- Bruck syndrome 0 trials Sub-types →
- Camurati-Engelmann disease 0 trials Sub-types →
- Catel-Manzke syndrome 0 trials
- Cole-Carpenter syndrome 0 trials Sub-types →
- Eiken syndrome 0 trials
- FAM111A-related skeletal dysplasia 0 trials Sub-types →
- Hartsfield-Bixler-Demyer syndrome 0 trials
- LRP5-related primary osteoporosis 0 trials
- Larsen-like osseous dysplasia-short stature syndrome 0 trials
- Larsen-like syndrome, B3GAT3 type 0 trials
- Lenz-Majewski hyperostotic dwarfism 0 trials
- Marshall-Smith syndrome 0 trials
- Richieri Costa-Pereira syndrome 0 trials
- Robinow syndrome 0 trials Sub-types →
- TRIP11-related skeletal dysplasia 0 trials Sub-types →
- TRPV4-related bone disorder 0 trials Sub-types →
- Tatton-Brown-Rahman overgrowth syndrome 0 trials
- Weaver syndrome 0 trials
- Yunis-Varon syndrome 0 trials
- Acrocoxomesomelic dysplasia 0 trials
- Adactyly of foot 0 trials Sub-types →
- Apodia 0 trials Sub-types →
- Autosomal dominant osteosclerosis, Worth type 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Baby rattle pelvis dysplasia 0 trials
- Bird headed-dwarfism, Montreal type 0 trials
- Bone dysplasia Moore type 0 trials
- Bone dysplasia corpus callosum agenesis 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Calvarial doughnut lesions with bone fragility and spondylometaphyseal dysplasia 0 trials
- Carpotarsal osteochondromatosis 0 trials
- Cerebrocostomandibular syndrome 0 trials
- Chondroectodermal dysplasia with night blindness 0 trials
- Cleidorhizomelic syndrome 0 trials
- Cognitive impairment - coarse facies - heart defects - obesity - pulmonary involvement - short stature - skeletal dysplasia syndrome 0 trials
- Colobomatous microphthalmia-rhizomelic dysplasia syndrome 0 trials
- Complex lethal osteochondrodysplasia 0 trials
- Congenital absence of both lower leg and foot 0 trials Sub-types →
- Congenital absence of thigh and lower leg with foot present 0 trials Sub-types →
- Congenital absence of upper arm and forearm with hand present 0 trials
- Craniometadiaphyseal dysplasia, wormian bone type 0 trials
- Craniotubular dysplasia, Ikegawa type 0 trials
- De la Chapelle dysplasia 0 trials
- Delayed membranous cranial ossification 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Dyschondrosteosis-nephritis syndrome 0 trials
- Dysplasia epiphysealis hemimelica 0 trials
- Dysplasia of head of femur, Meyer type 0 trials
- Dysspondyloenchondromatosis 0 trials
- Epimetaphyseal skeletal dysplasia 0 trials
- Familial osteodysplasia, Anderson type 0 trials
- Fibular aplasia-ectrodactyly syndrome 0 trials
- Genitopatellar syndrome 0 trials
- Genochondromatosis 0 trials Sub-types →
- Ghosal hematodiaphyseal dysplasia 0 trials
- Hyperostosis corticalis generalisata 0 trials
- Melorheostosis with osteopoikilosis 0 trials
- Mesomelic dwarfism-cleft palate-camptodactyly syndrome 0 trials
- Mesomelic dysplasia-digital anomalies-intellectual disability syndrome 0 trials
- Metaphyseal acroscyphodysplasia 0 trials
- Metaphyseal anadysplasia 0 trials Sub-types →
- Metaphyseal dysostosis-intellectual disability-conductive deafness syndrome 0 trials
- Metaphyseal dysplasia, Braun-Tinschert type 0 trials
- Microcephalic primordial dwarfism due to ZNF335 deficiency 0 trials
- Oculodentodigital dysplasia 0 trials Sub-types →
- Omodysplasia 0 trials Sub-types →
- Osteofibrous dysplasia 0 trials
- Osteoglophonic dysplasia 0 trials
- Pancreatic insufficiency-anemia-hyperostosis syndrome 0 trials
- Parietal foramina 0 trials Sub-types →
- Parietal foramina with cleidocranial dysplasia 0 trials
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome 0 trials
- Proximal femoral focal deficiency 0 trials
- Pseudodiastrophic dysplasia 0 trials
- Rhizomelic dysplasia, Ain-Naz type 0 trials
- Rhizomelic dysplasia, Patterson-Lowry type 0 trials
- Rhizomelic syndrome, Urbach type 0 trials
- Short stature-advanced bone age-early-onset osteoarthritis syndrome 0 trials
- Skeletal dysplasia-epilepsy-short stature syndrome 0 trials
- Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome 0 trials
- Split hand-foot malformation 1 with sensorineural hearing loss 0 trials
- Spondylometaphyseal dysplasia 0 trials Sub-types →
- Synpolydactyly 0 trials Sub-types →
- Tall stature-scoliosis-macrodactyly of the great toes syndrome 0 trials
- Thin ribs-tubular bones-dysmorphism syndrome 0 trials
- Tricho-dento-osseous syndrome 0 trials
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Bone development disease 2 trials · 527 incl. sub-types
9 sub-types
- Osteochondrodysplasia 12 trials · 380 incl. sub-types Sub-types →
- Dysostosis 0 trials · 85 incl. sub-types Sub-types →
- Developmental dysplasia of the hip 62 trials Sub-types →
- Spondylocarpotarsal synostosis syndrome 2 trials
- Microcephalic osteodysplastic dysplasia, Saul-Wilson type 1 trial
- Angioosteohypotrophic syndrome 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Odontoid hypoplasia 0 trials
- Segmental odontomaxillary dysplasia 0 trials
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Disease of bone structure 1 trial · 456 incl. sub-types
5 sub-types
- Scoliosis 137 trials · 234 incl. sub-types Sub-types →
- Spinal stenosis 120 trials · 154 incl. sub-types Sub-types →
- Spondylolisthesis 77 trials Sub-types →
- Spondylosis 70 trials
- Spondylolysis 6 trials
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Bone remodeling disease 5 trials · 411 incl. sub-types
6 sub-types
- Bone resorption disease 23 trials · 319 incl. sub-types Sub-types →
- Rickets 10 trials · 41 incl. sub-types Sub-types →
- Hyperostosis 2 trials · 26 incl. sub-types Sub-types →
- Osteosclerosis 1 trial · 16 incl. sub-types Sub-types →
- Fibrous dysplasia 11 trials Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
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Skull disorder 1 trial · 387 incl. sub-types
6 sub-types
- Paranasal sinus disorder 12 trials · 162 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Disorder of facial skeleton 4 trials · 132 incl. sub-types Sub-types →
- Cochlear disorder 6 trials
- Enlarged vestibular aqueduct syndrome 2 trials
- Petrositis 0 trials
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Metabolic bone disorder 9 trials · 316 incl. sub-types
4 sub-types
- Osteoporosis 277 trials · 295 incl. sub-types Sub-types →
- Chondrocalcinosis 5 trials · 7 incl. sub-types Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
- Bone Paget disease 2 trials Sub-types →
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Osteonecrosis 59 trials · 224 incl. sub-types
7 sub-types
- Avascular necrosis 80 trials · 141 incl. sub-types Sub-types →
- Osteonecrosis of genetic origin 0 trials · 102 incl. sub-types Sub-types →
- Osteochondrosis 8 trials · 46 incl. sub-types Sub-types →
- Osteoradionecrosis 14 trials · 15 incl. sub-types Sub-types →
- Dieterich disease 1 trial
- Kummell disease 1 trial
- Idiopathic phalangeal acro-osteolysis 0 trials
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Mucopolysaccharidosis type 3 7 trials · 18 incl. sub-types
4 sub-types
- Mucopolysaccharidosis type 3A 7 trials
- Mucopolysaccharidosis type 3B 6 trials
- Mucopolysaccharidosis type 3C 2 trials
- Mucopolysaccharidosis type 3D 0 trials
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Mucopolysaccharidosis type 1 11 trials · 16 incl. sub-types
3 sub-types
- Hurler syndrome 6 trials
- Hurler-Scheie syndrome 2 trials
- Scheie syndrome 1 trial
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Periostitis 0 trials · 16 incl. sub-types
2 sub-types
- Alveolar periostitis 16 trials
- Orbital periostitis 0 trials
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GM1 gangliosidosis 12 trials
3 sub-types
- GM1 gangliosidosis type 1 3 trials
- GM1 gangliosidosis type 2 3 trials
- GM1 gangliosidosis type 3 0 trials
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Mucopolysaccharidosis type 9 1 trial
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ACAN-related short stature spectrum 0 trials · 1 incl. sub-types
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Baastrup syndrome 0 trials
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Sagliker syndrome 0 trials
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Ainhum 0 trials
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Cervical rib disease 0 trials
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Coxoauricular syndrome 0 trials
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Metachondromatosis 0 trials
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Mueller-weiss syndrome 0 trials
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Proteoglycan-related bone disorder 0 trials
Most studied deeper sub-types
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Hope for kids with rare bone disorder: new drug shows promise in Long-Term trial
Disease control By invitation onlyThis study is for children with hypochondroplasia, a condition that causes short stature and bone differences. Researchers are testing a drug called infigratinib to see if it is safe and helps improve growth over the long term. Participants must have already completed a previous …
Phase 2 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Could a daily pill boost growth in kids with hypochondroplasia?
Disease control By invitation onlyThis study tests an oral drug called infigratinib in children with hypochondroplasia, a condition that causes short stature. The trial has two parts: first, all children receive the drug to see if it safely increases their growth rate; then, some will switch to a placebo to confi…
Phase 2/3 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Your extracted tooth could save your jawbone for implants
Disease control By invitation onlyThis study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…
Sponsor: Istanbul Saglik Bilimleri University • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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New hip implant study aims to reduce dislocation risk in cancer patients
Disease control OngoingThis study looks at two types of hip implants used in total hip replacement for people with metastatic bone disease (cancer that has spread to the hip bone). The goal is to see if a newer implant design (dual mobility) is as good as a standard one (constrained liner) at preventin…
Sponsor: Rigshospitalet, Denmark • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for kids with dwarfism: daily shot may boost growth
Disease control OngoingThis study tests a daily injection called BMN 111 in about 70 children with achondroplasia, the most common form of dwarfism. The goal is to see if the drug is safe and helps children grow taller over several years. All participants had already received BMN 111 or a placebo in a …
Phase 2 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Could a daily injection spare babies with dwarfism from risky neck surgery?
Disease control OngoingThis study tests a drug called vosoritide in infants with achondroplasia (the most common form of dwarfism) who are at high risk of needing a surgery to relieve pressure on the spinal cord at the base of the skull. The main goal is to see if the drug is safe and if it can help en…
Phase 2 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Growth drug shows promise for kids with dwarfism
Disease control OngoingThis study tests a drug called BMN 111 in children with achondroplasia, the most common form of dwarfism. The goal is to see if it safely helps them grow taller over several years. About 119 children who completed an earlier study will take the drug and be monitored for growth, d…
Phase 3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Hope for growth: new drug shows promise in Long-Term achondroplasia study
Disease control OngoingThis study looks at the long-term safety and effects of a daily injection called BMN 111 in children with achondroplasia, a common form of dwarfism. It includes 30 children who have already taken the drug for two years in a previous study. The goal is to see if the drug remains s…
Phase 2 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New drug aims to help short-statured children grow taller
Disease control OngoingThis study tests a drug called vosoritide to see if it can safely help children with hypochondroplasia grow faster. About 80 children aged 3 to 17 with a confirmed genetic diagnosis and very short stature will receive either the drug or a placebo for one year. The main goal is to…
Phase 3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New oral drug shows promise for helping children with dwarfism grow
Disease control By invitation onlyThis study tests a daily oral drug called infigratinib in 300 children with achondroplasia, the most common form of dwarfism. The drug aims to improve bone growth by targeting a specific protein. Researchers will monitor safety and growth over several years, including children wh…
Phase 2 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Tiny camera may make dental sinus surgery safer
Symptom relief OngoingResearchers compare two ways to lift the sinus floor before placing dental implants in the upper jaw. One method uses a small camera (endoscope) to check the sinus membrane during drilling and grafting, while the other relies on standard techniques. The trial enrolls 24 adults wi…
Sponsor: Nahla Mahmoud Awad • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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New computer model aims to predict fractures in rare bone disorder patients
Knowledge-focused OngoingThis study is testing whether a computer tool called MEKANOS can better predict the risk of hip fractures in people with Fibrous Dysplasia or McCune-Albright Syndrome. Researchers will take CT scans of the femur and use the tool to calculate bone strength. The goal is to improve …
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC