Bone disorder
MONDO:0005381Diseases of bones.
Also known as: bone element disease, bone element disease or disorder, disease of bone element, disease or disorder of bone element, disorder of bone element, rare bone disease related to a common gene or pathway defect
6305 clinical trials for this condition and its sub-types, 53 tagged with Bone disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Bone disorder
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Bone inflammation disease 1 trial · 2,674 incl. sub-types
6 sub-types
- Arthritic joint disease 195 trials · 2,555 incl. sub-types Sub-types →
- Epicondylitis 86 trials
- Osteomyelitis 43 trials · 46 incl. sub-types Sub-types →
- Osgood-Schlatter disease 5 trials
- Mastoiditis 1 trial
- Caffey disease 0 trials
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Bone neoplasm 26 trials · 2,118 incl. sub-types
20 sub-types
- Bone cancer 79 trials · 1,923 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Bone benign neoplasm 1 trial · 70 incl. sub-types Sub-types →
- Notochordal tumor 0 trials · 34 incl. sub-types Sub-types →
- Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone 0 trials · 7 incl. sub-types Sub-types →
- Solitary bone cyst 6 trials
- Vascular bone neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Hereditary multiple osteochondromas 3 trials Sub-types →
- Hyperparathyroidism 2 with jaw tumors 1 trial
- Neonatal severe primary hyperparathyroidism 1 trial
- Neoplasm of femur 0 trials · 1 incl. sub-types Sub-types →
- OSLAM syndrome 0 trials
- Aneurysmal bone cyst 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Hyperparathyroidism 1 0 trials
- Hyperparathyroidism 3 0 trials
- Hyperparathyroidism 4 0 trials
- Juvenile hyaline fibromatosis 0 trials
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Skeletal dysplasia 1 trial · 663 incl. sub-types
119 sub-types
- Osteochondrodysplasia 12 trials · 381 incl. sub-types Sub-types →
- Lysosomal storage disease with skeletal involvement 0 trials · 64 incl. sub-types Sub-types →
- Chondrodysplasia punctata 0 trials · 39 incl. sub-types Sub-types →
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- Non-syndromic limb reduction defect 0 trials · 35 incl. sub-types Sub-types →
- FGFR3-related chondrodysplasia 0 trials · 33 incl. sub-types Sub-types →
- Abnormal mineralization disorder 0 trials · 22 incl. sub-types Sub-types →
- Syndromic craniosynostosis 1 trial · 22 incl. sub-types Sub-types →
- Osteopetrosis 6 trials · 14 incl. sub-types Sub-types →
- Amniotic band syndrome 8 trials · 9 incl. sub-types Sub-types →
- Primordial dwarfism and slender bone disorder 0 trials · 9 incl. sub-types Sub-types →
- Acromelic dysplasia 0 trials · 8 incl. sub-types Sub-types →
- SHOX-related short stature 6 trials
- Polydactyly-syndactyly-triphalangism 0 trials · 6 incl. sub-types Sub-types →
- McCune-Albright syndrome 5 trials
- Primary osteolysis 0 trials · 5 incl. sub-types Sub-types →
- Filamin-related bone disorder 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Proteus syndrome 2 trials
- SLC26A2-related skeletal dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Acheiria 0 trials · 2 incl. sub-types Sub-types →
- Bent bone dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Congenital absence of both forearm and hand 1 trial · 2 incl. sub-types Sub-types →
- Metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome 2 trials
- Short rib dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Spondylodysplastic dysplasia 0 trials · 2 incl. sub-types Sub-types →
- 2q37 microdeletion syndrome 1 trial
- COMP-related skeletal dysplasia 0 trials · 1 incl. sub-types Sub-types →
- Currarino triad 1 trial
- Sotos syndrome 1 trial
- Chondromalacia patellae 1 trial
- Coxopodopatellar syndrome 1 trial
- Craniofrontonasal syndrome 1 trial
- Bruck syndrome 0 trials Sub-types →
- Camurati-Engelmann disease 0 trials Sub-types →
- Catel-Manzke syndrome 0 trials
- Cole-Carpenter syndrome 0 trials Sub-types →
- Eiken syndrome 0 trials
- FAM111A-related skeletal dysplasia 0 trials Sub-types →
- Hartsfield-Bixler-Demyer syndrome 0 trials
- LRP5-related primary osteoporosis 0 trials
- Larsen-like osseous dysplasia-short stature syndrome 0 trials
- Larsen-like syndrome, B3GAT3 type 0 trials
- Lenz-Majewski hyperostotic dwarfism 0 trials
- Marshall-Smith syndrome 0 trials
- Richieri Costa-Pereira syndrome 0 trials
- Robinow syndrome 0 trials Sub-types →
- TRIP11-related skeletal dysplasia 0 trials Sub-types →
- TRPV4-related bone disorder 0 trials Sub-types →
- Tatton-Brown-Rahman overgrowth syndrome 0 trials
- Weaver syndrome 0 trials
- Yunis-Varon syndrome 0 trials
- Acrocoxomesomelic dysplasia 0 trials
- Adactyly of foot 0 trials Sub-types →
- Apodia 0 trials Sub-types →
- Autosomal dominant osteosclerosis, Worth type 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Baby rattle pelvis dysplasia 0 trials
- Bird headed-dwarfism, Montreal type 0 trials
- Bone dysplasia Moore type 0 trials
- Bone dysplasia corpus callosum agenesis 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Calvarial doughnut lesions with bone fragility and spondylometaphyseal dysplasia 0 trials
- Carpotarsal osteochondromatosis 0 trials
- Cerebrocostomandibular syndrome 0 trials
- Chondroectodermal dysplasia with night blindness 0 trials
- Cleidorhizomelic syndrome 0 trials
- Cognitive impairment - coarse facies - heart defects - obesity - pulmonary involvement - short stature - skeletal dysplasia syndrome 0 trials
- Colobomatous microphthalmia-rhizomelic dysplasia syndrome 0 trials
- Complex lethal osteochondrodysplasia 0 trials
- Congenital absence of both lower leg and foot 0 trials Sub-types →
- Congenital absence of thigh and lower leg with foot present 0 trials Sub-types →
- Congenital absence of upper arm and forearm with hand present 0 trials
- Craniometadiaphyseal dysplasia, wormian bone type 0 trials
- Craniotubular dysplasia, Ikegawa type 0 trials
- De la Chapelle dysplasia 0 trials
- Delayed membranous cranial ossification 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Dyschondrosteosis-nephritis syndrome 0 trials
- Dysplasia epiphysealis hemimelica 0 trials
- Dysplasia of head of femur, Meyer type 0 trials
- Dysspondyloenchondromatosis 0 trials
- Epimetaphyseal skeletal dysplasia 0 trials
- Familial osteodysplasia, Anderson type 0 trials
- Fibular aplasia-ectrodactyly syndrome 0 trials
- Genitopatellar syndrome 0 trials
- Genochondromatosis 0 trials Sub-types →
- Ghosal hematodiaphyseal dysplasia 0 trials
- Hyperostosis corticalis generalisata 0 trials
- Melorheostosis with osteopoikilosis 0 trials
- Mesomelic dwarfism-cleft palate-camptodactyly syndrome 0 trials
- Mesomelic dysplasia-digital anomalies-intellectual disability syndrome 0 trials
- Metaphyseal acroscyphodysplasia 0 trials
- Metaphyseal anadysplasia 0 trials Sub-types →
- Metaphyseal dysostosis-intellectual disability-conductive deafness syndrome 0 trials
- Metaphyseal dysplasia, Braun-Tinschert type 0 trials
- Microcephalic primordial dwarfism due to ZNF335 deficiency 0 trials
- Oculodentodigital dysplasia 0 trials Sub-types →
- Omodysplasia 0 trials Sub-types →
- Osteofibrous dysplasia 0 trials
- Osteoglophonic dysplasia 0 trials
- Pancreatic insufficiency-anemia-hyperostosis syndrome 0 trials
- Parietal foramina 0 trials Sub-types →
- Parietal foramina with cleidocranial dysplasia 0 trials
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome 0 trials
- Proximal femoral focal deficiency 0 trials
- Pseudodiastrophic dysplasia 0 trials
- Rhizomelic dysplasia, Ain-Naz type 0 trials
- Rhizomelic dysplasia, Patterson-Lowry type 0 trials
- Rhizomelic syndrome, Urbach type 0 trials
- Short stature-advanced bone age-early-onset osteoarthritis syndrome 0 trials
- Skeletal dysplasia-epilepsy-short stature syndrome 0 trials
- Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome 0 trials
- Split hand-foot malformation 1 with sensorineural hearing loss 0 trials
- Spondylometaphyseal dysplasia 0 trials Sub-types →
- Synpolydactyly 0 trials Sub-types →
- Tall stature-scoliosis-macrodactyly of the great toes syndrome 0 trials
- Thin ribs-tubular bones-dysmorphism syndrome 0 trials
- Tricho-dento-osseous syndrome 0 trials
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Bone development disease 2 trials · 528 incl. sub-types
9 sub-types
- Osteochondrodysplasia 12 trials · 381 incl. sub-types Sub-types →
- Dysostosis 0 trials · 85 incl. sub-types Sub-types →
- Developmental dysplasia of the hip 62 trials Sub-types →
- Spondylocarpotarsal synostosis syndrome 2 trials
- Microcephalic osteodysplastic dysplasia, Saul-Wilson type 1 trial
- Angioosteohypotrophic syndrome 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Odontoid hypoplasia 0 trials
- Segmental odontomaxillary dysplasia 0 trials
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Disease of bone structure 1 trial · 456 incl. sub-types
5 sub-types
- Scoliosis 137 trials · 234 incl. sub-types Sub-types →
- Spinal stenosis 120 trials · 154 incl. sub-types Sub-types →
- Spondylolisthesis 77 trials Sub-types →
- Spondylosis 70 trials
- Spondylolysis 6 trials
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Bone remodeling disease 5 trials · 413 incl. sub-types
6 sub-types
- Bone resorption disease 24 trials · 321 incl. sub-types Sub-types →
- Rickets 10 trials · 41 incl. sub-types Sub-types →
- Hyperostosis 2 trials · 26 incl. sub-types Sub-types →
- Osteosclerosis 1 trial · 16 incl. sub-types Sub-types →
- Fibrous dysplasia 11 trials Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
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Skull disorder 1 trial · 388 incl. sub-types
6 sub-types
- Paranasal sinus disorder 12 trials · 163 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Disorder of facial skeleton 4 trials · 132 incl. sub-types Sub-types →
- Cochlear disorder 6 trials
- Enlarged vestibular aqueduct syndrome 2 trials
- Petrositis 0 trials
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Metabolic bone disorder 9 trials · 317 incl. sub-types
4 sub-types
- Osteoporosis 278 trials · 296 incl. sub-types Sub-types →
- Chondrocalcinosis 5 trials · 7 incl. sub-types Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
- Bone Paget disease 2 trials Sub-types →
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Osteonecrosis 59 trials · 224 incl. sub-types
7 sub-types
- Avascular necrosis 80 trials · 141 incl. sub-types Sub-types →
- Osteonecrosis of genetic origin 0 trials · 102 incl. sub-types Sub-types →
- Osteochondrosis 8 trials · 46 incl. sub-types Sub-types →
- Osteoradionecrosis 14 trials · 15 incl. sub-types Sub-types →
- Dieterich disease 1 trial
- Kummell disease 1 trial
- Idiopathic phalangeal acro-osteolysis 0 trials
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Mucopolysaccharidosis type 3 7 trials · 18 incl. sub-types
4 sub-types
- Mucopolysaccharidosis type 3A 7 trials
- Mucopolysaccharidosis type 3B 6 trials
- Mucopolysaccharidosis type 3C 2 trials
- Mucopolysaccharidosis type 3D 0 trials
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Periostitis 0 trials · 17 incl. sub-types
2 sub-types
- Alveolar periostitis 17 trials
- Orbital periostitis 0 trials
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Mucopolysaccharidosis type 1 11 trials · 16 incl. sub-types
3 sub-types
- Hurler syndrome 6 trials
- Hurler-Scheie syndrome 2 trials
- Scheie syndrome 1 trial
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GM1 gangliosidosis 12 trials
3 sub-types
- GM1 gangliosidosis type 1 3 trials
- GM1 gangliosidosis type 2 3 trials
- GM1 gangliosidosis type 3 0 trials
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Mucopolysaccharidosis type 9 1 trial
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ACAN-related short stature spectrum 0 trials · 1 incl. sub-types
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Baastrup syndrome 0 trials
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Sagliker syndrome 0 trials
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Ainhum 0 trials
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Cervical rib disease 0 trials
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Coxoauricular syndrome 0 trials
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Metachondromatosis 0 trials
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Mueller-weiss syndrome 0 trials
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Proteoglycan-related bone disorder 0 trials
Most studied deeper sub-types
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New implant-free surgery shows promise for shoulder instability
Disease control CompletedThis pilot study tested a surgical technique using donor tissue without metal implants to treat recurrent shoulder dislocation with bone loss. Twenty participants were followed for 24 months to measure arm function and safety. The goal was to see if this approach can stabilize th…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Can a vitamin d pill improve bone health in rare genetic disease?
Disease control CompletedThis study tested whether giving only calcitriol (a form of vitamin D) to 16 children and adults with X-linked hypophosphatemia (XLH) could raise blood phosphate levels and improve bone growth without causing kidney stones. Participants took increasing doses of calcitriol for one…
Early phase 1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New drug shows promise for boosting growth in kids with dwarfism
Disease control CompletedThis study tested a daily oral drug called infigratinib in 114 children aged 3 to 18 with achondroplasia, the most common form of dwarfism. The goal was to see if it could safely increase their growth rate compared to a placebo. The trial is now complete, and results will show wh…
Phase 3 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Bone paste shows promise in repairing defects after tumor surgery
Disease control CompletedThis study tested a new paste that is placed into bone defects after removing benign tumors or cysts. 29 patients received the paste during surgery and were followed for 12 months. The goal was to see if the paste helps bone heal and is safe to use.
Sponsor: Biovico Sp. z o.o. • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Tailored titanium meshes rebuild jawbone for dental implants
Disease control CompletedThis study tested whether custom-made titanium meshes could help rebuild lost jawbone in 15 people who needed dental implants. The meshes were designed using 3D imaging and computer modeling to fit each person's defect. Results measured how much new bone grew and how often the me…
Sponsor: TC Erciyes University • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New drug shows promise for boosting growth in kids with dwarfism
Disease control CompletedThis study tested an oral drug called infigratinib in 84 children aged 3 to 11 with achondroplasia, the most common form of dwarfism. The goal was to see if it could safely increase their growth rate. Children took the drug daily, and researchers measured height changes and side …
Phase 2 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New hope for fragile bones: monthly shots may strengthen skeleton in paralyzed women
Disease control CompletedThis pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…
Phase 2 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Cutting radiation in CT scans: a new test of Ultra-Low-Dose imaging
Diagnosis CompletedThis trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated Aug 16, 2026 00:00 UTC
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No-Radiation scoliosis screening could spare thousands of girls from unnecessary x-rays
Diagnosis CompletedThis study tested whether a radiation-free ultrasound system can accurately screen for scoliosis in 442 Hong Kong schoolgirls aged around 10, who are at high risk for curve progression. The goal was to see if ultrasound could identify which girls truly need an X-ray, reducing unn…
Sponsor: Chinese University of Hong Kong • Aim: Diagnosis
Last updated Jun 27, 2026 12:01 UTC
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Spinal injury patients may keep stronger bones with simple infusion
Prevention CompletedThis study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…
Phase 2 • Sponsor: Northwestern University • Aim: Prevention
Last updated Jun 27, 2026 08:01 UTC
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Sailing therapy sets sail for rare bone disease patients
Symptom relief CompletedThis pilot study tested whether a 5-day sailing therapy program followed by 3 months of home-based telerehabilitation is safe and feasible for young people aged 12–30 with rare skeletal disorders. 24 participants were randomly assigned to either the sailing-plus-rehab group or a …
Sponsor: Istituto Ortopedico Rizzoli • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Pre-surgery rehab shows promise for rare shoulder deformity in child
Symptom relief CompletedThis study looked at whether a structured physical therapy program before surgery could help an 11-year-old girl with a deformed upper arm bone. The girl had chronic bone infection that left her with shoulder deformity. Over 12 sessions, she received treatments like electrical ne…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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No-Radiation 3D imaging tested for scoliosis and obesity
Knowledge-focused CompletedThis completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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No treatment, just tracking: PROPEL study watches how kids with achondroplasia grow
Knowledge-focused CompletedThis study followed 271 children with achondroplasia, ages 2.5 to 17, to understand their growth, medical issues, and quality of life over time. No medication or treatment was given. The goal was to gather natural history data to help design future clinical trials.
Sponsor: QED Therapeutics, a BridgeBio company • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Thumb bone index may predict scoliosis growth spurts
Knowledge-focused CompletedThis study tested a new thumb bone staging system (TOCI) to predict skeletal maturity and curve progression in 1,500 teens with idiopathic scoliosis. Researchers evaluated thumb X-rays to see if the simple index could replace complex methods like the Risser sign or Greulich-Pyle …
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC