Alcohol-induced disorders

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested an experimental drug called ADX-629 in 4 adults with moderate alcohol-related hepatitis. The goal was to see if the drug is safe and can help control liver inflammation. Participants had to stop drinking alcohol during the trial. The study is now complete, and r…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This phase 3 trial tested whether a single injection of radioactive lipiodol (Lipiocis) into the liver artery could prevent hepatocellular carcinoma from coming back after surgery or ablation. The study enrolled 73 adults with cirrhosis and one or two liver tumors that had been s…

This study tested whether certain drugs (NNC0194-0499, semaglutide, and cagrilintide) can reduce liver damage and alcohol use in people with alcohol-related liver disease. About 270 adults with a history of heavy drinking took part. Participants received different drug combinatio…

This early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study looked at whether early liver transplantation can help people with severe alcoholic hepatitis who did not get better with medical treatment. Researchers compared alcohol relapse rates in 284 patients who received early transplants to those transplanted after a 6-month …

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within two months took part. The goal was to see if the antibiotic,…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested a phone-based program called MommyCheckup to see if it helps pregnant women who drink alcohol cut back or stop. The program includes a short motivational video and tailored text messages. Researchers enrolled 384 pregnant women across three states to see if the …

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested a culturally adapted mobile health program called Mobile CHOICES to help urban American Indian and Alaska Native young women (ages 16-20) avoid drinking alcohol during pregnancy. The goal was to reduce the risk of Fetal Alcohol Spectrum Disorders, which cause li…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested whether a therapy called dialectical behavior therapy (DBT) is helpful and acceptable for teens aged 14–17 with fetal alcohol spectrum disorders (FASD). Nine teens and their caregivers took part in a program that included individual therapy, group skills trainin…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested a smartphone app called FMF Connect for parents and caregivers of children with fetal alcohol spectrum disorders (FASD). The app provides helpful information and peer support to manage children's behavior. 129 parents participated, and researchers measured chang…

This pilot study tested whether a daily dose of EGCG, a natural compound found in green tea, could improve cognitive performance in 36 children aged 7 to 14 with fetal alcohol syndrome. The children took EGCG for one year and had their thinking skills measured at the start, at 6 …

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This completed study followed 1,681 people with steatotic liver disease (fatty liver) in Germany to observe how the condition progresses over time. Researchers measured liver stiffness, inflammation, and tracked whether participants developed heart problems or tumors. The goal wa…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This study looked at how consistent FibroScan, a non-invasive device that measures liver stiffness and fat, is when used by different operators on different days. 108 adults with fatty liver or alcohol-related liver disease had multiple scans and blood tests over two visits. The …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study looked at over 5,000 adults in Zambia to find out how many have hepatitis B and how many need treatment. Researchers tested people in their homes and then did more tests on those who tested positive. The goal was to gather information, not to test a new treatment or cu…

This study looked at 188 children (ages 0-18) with Fetal Alcohol Spectrum Disorders (FASD) in Reunion Island to better describe the condition and find a unique "epigenetic signature" in their DNA. Researchers collected blood and cheek swabs from a small group of children with FAS…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This completed study looked at whether fragments from gut bacteria (called peptidoglycans) are linked to alcohol-related liver disease. 40 participants with liver cirrhosis provided stool samples to measure these fragments. The goal was to see if these fragments could be used as …

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…