University Health Network, Toronto

This study tests a drug called avelumab in 25 people with advanced penile cancer who cannot have standard chemo or whose cancer got worse after chemo. Avelumab works by blocking a protein that helps tumors hide from the immune system, which may shrink or slow the cancer. The main…

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have received a liver transplant and have poorly controlled diabetes. The goal is to see which drug better improves blood sugar control and reduces body weight. Participants will take one …

This study tests a combination of two drugs, atezolizumab and bevacizumab, in people with liver cancer or lung cancer that has spread to the liver. The goal is to see how long the cancer stays under control. Researchers will collect blood and tumor samples to understand how the d…

This study tests whether storing donor lungs at 10°C instead of the usual ice-cold temperature can reduce severe lung injury after transplant. About 300 people receiving a lung transplant will take part. The goal is to see if this new storage method is safe and helps improve reco…

This early-phase study tests a new investigational drug (RP-6306) combined with two standard chemotherapies (carboplatin and paclitaxel) in people with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find the safest dose…

This study looks at how teriparatide, a bone-building drug, affects the inner structure of bones in 100 men and women with osteoporosis over 24 months. Using a special 3D scanner, researchers measure changes in bone thickness and microarchitecture at the wrist and shin. The goal …

This study is for people with malignant pleural mesothelioma, a rare cancer of the lung lining. It tests a new approach that combines a special type of radiation (boost radiation) with surgery to remove the affected tissue. The main goal is to find the safest radiation dose that …

This study tests a new treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, called T cells, which are genetically modified in a lab to better recognize and attack cancer cells. The main goa…

This study tests a non-live RSV vaccine in 100 adults who have received a lung or stem cell transplant. The goal is to see if the vaccine is safe and helps their immune system fight RSV, a common virus that can be dangerous for them. Participants will give blood samples and be mo…

This study explores whether a treatment made from healthy gut bacteria (MET-4) can help cancer patients respond better to standard immunotherapy. About 65 adults with advanced solid tumors will receive MET-4 alongside their usual immunotherapy or continue immunotherapy alone. Res…

This study tested whether a special mix of gut bacteria (MET-2) could help clear antibiotic-resistant germs from the body after a bloodstream infection. It was designed for adults not in the ICU who had a resistant infection. The trial was withdrawn before enrolling anyone, so no…

This study looks at whether a stem cell transplant or the best non-transplant treatments work better for people with high-risk myelofibrosis, a serious bone marrow cancer. About 90 participants will choose which treatment they want, and researchers will track their survival and q…

This early-phase study tests whether lungs from hepatitis C positive donors can be safely transplanted into hepatitis C negative patients awaiting a lung transplant. The approach uses a special lung preservation machine (EVLP) to possibly reduce the virus, and if infection occurs…

This study tests whether adding the targeted drug selumetinib to standard chemotherapy (cisplatin and gemcitabine) helps shrink tumors or slow cancer growth in people with advanced biliary tract or gallbladder cancer. About 57 adults who have not had prior treatment will receive …

This study tests a treatment plan for people with pancreatic cancer that has spread to a major artery. Participants receive chemotherapy and radiation before surgery to remove the tumor and the affected artery. The goal is to see if this aggressive approach is safe and helps pati…

This study tests a treatment called Lu-DOTATATE, which delivers radiation directly to neuroendocrine tumor cells. About 195 people with tumors that have a specific marker (somatostatin receptors) will receive up to 4 cycles of this therapy, with doses adjusted for each person. Th…

This phase 2 study tested whether combining an experimental vaccine (DPX-Survivac) with an immunotherapy drug (pembrolizumab) and low-dose chemotherapy can shrink tumors in people with advanced ovarian, fallopian tube, or peritoneal cancer. The vaccine trains the immune system to…

This early-stage study tests a new approach for people with acute myeloid leukemia (AML) that has returned or is likely to return, and who cannot have a bone marrow transplant. Researchers take the patient's own leukemia cells, modify them in the lab to produce a protein called I…

This study looks at how teriparatide, a drug that builds new bone, changes bone structure in 60 postmenopausal women with severe osteoporosis over two years. Researchers want to see if the drug affects bone thickness differently at the wrist versus the ankle, which could help pre…

This study tests whether adding hydroxychloroquine (a malaria drug) to standard chemotherapy can improve treatment for people with advanced colorectal cancer that has spread. The drug targets cancer cells that survive initial treatment. About 155 participants will be screened, an…

This study tests whether using MRI to guide a radiation boost to visible prostate tumors is feasible and safe. Forty men with localized prostate cancer will receive the targeted boost before or after standard whole-gland radiation. They will be followed for up to 5 years to check…

This study looks at whether a liquid biopsy (a blood test) can help doctors decide on treatment faster for people with advanced non-small cell lung cancer. About 170 adults with newly diagnosed, advanced lung cancer will have their blood tested for genetic changes. The goal is to…

This study tests a new type of PET/MRI scan to tell the difference between a brain tumor growing back and a side effect of radiation called radionecrosis. Both conditions look very similar on regular scans and cause similar symptoms, so doctors often need surgery to find out whic…

This study is developing a blood test to find early-stage tumors in people with hereditary cancer syndromes. Researchers will collect blood samples and medical data from 1,416 participants across Canada. They will also interview patients and doctors to see if the test is useful a…

This study tests whether low-intensity focused ultrasound (LIFUS) can reduce tremors and the feeling of falling in people with primary orthostatic tremor (POT), a rare condition where leg muscles shake when standing. Researchers will use MRI to guide sound waves to a deep brain a…

This study tested whether a mindfulness program delivered remotely could help healthcare workers feel less stressed and burned out during the COVID-19 pandemic. 43 employees from a hospital radiation medicine program took part. Researchers measured stress and burnout levels befor…

This study tests if a supervised exercise program is safe and helpful for people with painful bone metastases (cancer that spread to bones) after they receive standard radiation therapy. About 20 adults with cancer will take part. The goal is to see if exercise can improve pain, …

This study tests a 10-week, at-home exercise program for cancer survivors who have lasting nerve pain, numbness, or tingling from chemotherapy. Researchers want to see if the program is safe, doable, and helpful. Participants will exercise remotely, get health coaching calls, and…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms), combined with talk therapy, can help people with advanced cancer feel less anxious about death and dying. Fifteen adults with stage IV cancer will receive the treatment and be mo…

This study looks at whether a small dose of a lighter-than-spinal-fluid anesthetic, injected at the lowest spine gap, can still numb the area enough for hip or knee replacement surgery. The goal is to help patients regain feeling and movement in their legs faster after the operat…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This study observes 12 people with stage IV non-small cell lung cancer who are already receiving immunotherapy (nivolumab or pembrolizumab) and also get palliative radiation to the chest. The goal is to track side effects from the combination and how it affects quality of life. P…

This study looks at how doctors use albumin and other fluids during heart surgery in adults. It does not test new treatments but collects information to help guide future care. About 104 patients will be observed to understand current practices and improve outcomes.

This study looks at whether adding a second type of PET scan (FDG) to the standard scan (DOTATATE) gives doctors more information about neuroendocrine tumors. About 40 adults with grade 2 or 3 gastroenteropancreatic neuroendocrine tumors will get both scans. The goal is to see if…

This study explores whether a special PET scan using a tracer called FAZA can detect low oxygen levels (hypoxia) in cervix cancer tumors. Hypoxia may affect how tumors grow and respond to standard treatments like radiation and chemotherapy. About 30 adults with cervix cancer will…

This study looks at the long-term side effects in people who survived nasopharyngeal cancer after radiation and chemotherapy. Researchers will check quality of life, thinking skills, hearing, and hormone levels in 108 survivors who are at least four years past treatment. The goal…

This study is testing how well a new MRI-guided radiotherapy machine works and how it affects the care team's workflow. About 150 adults with solid tumors will be treated or imaged using this machine. The goal is to see if the machine can be used smoothly in everyday care, not to…

This study looks at how oxygen levels and internal pressure inside cervix tumors affect the success of radiation therapy. Researchers measured these factors in 346 patients before and during treatment. The goal is to learn if these measurements can help predict which patients wil…

This study looks at how tumors evolve when patients with advanced head and neck cancer or melanoma receive immune checkpoint inhibitors. Researchers will analyze DNA from blood samples and tumor biopsies to see how the cancer changes under treatment. The goal is to better underst…

This study looks at adults with small, low-risk papillary thyroid cancer that hasn't spread. Patients can choose between active surveillance (close monitoring) or surgery to remove the thyroid. Researchers track how many choose each option, why, and how they feel about their deci…

This study is looking at 200 people with pancreatic cancer to see if analyzing their tumor's genes and growing mini-tumors in a lab can help doctors choose more personalized treatments. Participants provide tissue, blood, and stool samples, and their medical records are reviewed.…

This study tests an online questionnaire called CHAMP that older adults (65+) with cancer can fill out before their doctor visit. The tool helps doctors understand each patient's overall health to make better treatment decisions. About 180 participants from four hospitals will us…

This study explores whether low-intensity ultrasound can safely and precisely stimulate deep brain regions involved in Parkinson's disease and dystonia. Ten adults who already have deep brain stimulation (DBS) implants will receive ultrasound pulses while their DBS is off. Resear…

This study uses heart scans and blood tests to understand why some people develop heart inflammation after COVID-19 vaccination. Researchers are comparing people with and without symptoms to find early warning signs. The goal is to identify those at risk and determine if long-ter…

This study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. Researchers collect blood and tumor samples before and during treatment to track these changes. The goal …

This study involves 12 people with cervix cancer who are receiving radiation therapy. The goal is to use frequent MRI scans to see how the tumor and nearby organs move during treatment. By understanding this movement, doctors hope to better target the tumor and spare healthy tiss…

This study checks if Fitbit watches can reliably measure heart rate, breathing, oxygen levels, sleep, and activity in patients admitted to a general medicine ward. About 100 adults will wear a Fitbit alongside standard medical monitors to see how well the device matches up. The g…

This study looks at whether the diabetes drug semaglutide (Ozempic/Wegovy) causes a 'full stomach' in patients who have fasted before elective surgery. A full stomach raises the risk of serious complications during anesthesia. Researchers will use ultrasound to check stomach cont…

This study looks at whether vitamin D levels in the blood can help identify kidney injury in people who have had heart surgery. Researchers will measure vitamin D and kidney function in 46 adults before and after surgery. The goal is to see if vitamin D can serve as an early warn…

This study follows 180 adults with cancer that has spread to the thigh bone and is at high risk of breaking. The goal is to see how well surgery (with or without radiation) or radiation alone helps patients walk, manage pain, and maintain quality of life over 6 months. The study …

This study looks at how radiation treatment for brain tumors that have spread from other cancers affects thinking and memory. Researchers will use new MRI techniques before and after radiation to see if they can spot early signs of cognitive decline. 110 patients will be followed…

This study tests whether a web-based education program can improve older adults' knowledge about brain health before surgery. Researchers will measure changes in knowledge scores after 164 participants aged 60 and older complete the online module. The goal is to empower patients …

This study aims to find clinical and genetic factors that increase the risk of a rare type of thigh bone fracture (atypical femur fracture) in people taking common osteoporosis drugs. Researchers will compare 330 people who had this fracture with 660 similar people who did not. T…

This study looks at how low oxygen levels and high fluid pressure inside cervical cancer tumors affect how well radiation therapy works. Researchers will measure these factors in 500 patients before and during treatment. The goal is to find the best way to identify tumors that ma…

This study tests whether a green dye, injected during weight-loss surgery, helps surgeons see blood flow at the new stomach connection. About 300 adults having Roux-en-Y gastric bypass will take part. The goal is to see if better blood flow checks can lower the risk of ulcers, le…

This study tests whether a CT scan done right after removing a lung nodule can help surgeons decide if they need to remove more tissue. Currently, doctors only know if the cancer was fully removed after the surgery, when a pathologist checks the sample. By giving surgeons immedia…

This study looks at the complete genetic makeup of people and families who have a high risk of hereditary cancer but no known gene mutation. Researchers will analyze blood and tumor samples using advanced DNA and RNA sequencing to discover new gene changes that may cause cancer. …

This study tests a very small camera, called a composite optical fiberscope, to see if it can reach and view lung tumors in the outer parts of the lung. Researchers will use lung tissue removed from 50 patients during surgery. The goal is to see if the camera can help doctors see…

This study aims to establish what normal swallowing looks like in healthy adults of all ages using video X-rays. Researchers will compare these normal patterns to those of people with swallowing difficulties (dysphagia) to create clear cutoffs for diagnosis. About 580 participant…

This study tests two different drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to unders…

This study explores whether a special PET scan using a tracer called FAZA can detect low oxygen levels (hypoxia) in lung cancer tumors. Low oxygen can affect how cancer grows and responds to treatments like radiation. The study involves 36 adults with stage II or III lung cancer …

This study was designed to see how a 14-day course of an IL-1 blocking drug (Anakinra) changes the immune environment inside early-stage triple-negative or ER-low breast cancer tumors. Researchers planned to compare tumor samples taken before and after treatment in about 0 partic…

This study aims to develop a simple blood test (liquid biopsy) to monitor high-grade gliomas, an aggressive type of brain tumor. Researchers will collect blood samples from 70 adult patients before and after treatment to see if they can detect tumor DNA and track changes over tim…

This study tests a new way to deliver radiation therapy for cancer using an MRI machine built into the radiation device. The goal is to see if real-time imaging can help doctors target tumors more precisely and reduce side effects. About 377 adults with any type or stage of cance…

This study looks at tumor samples from over 3,000 people with advanced cancers to find specific genetic markers (biomarkers). The goal is to help doctors choose which targeted therapy clinical trials might work best for each patient. It does not test a new treatment itself, but a…

This study looks at two ways to manage very low-risk papillary thyroid cancer: active surveillance (regular check-ups to watch for changes) or immediate surgery. Researchers want to see how often each approach fails to control the disease over the long term. About 450 adults with…

This study looks at whether a biomarker called GATA6 can help predict how well chemotherapy works for people with pancreatic cancer that can be surgically removed. About 84 participants will receive chemotherapy before and after surgery, and researchers will measure their GATA6 l…

This study reviewed the records of 505 adults who had heart surgery to understand how doctors give fluids (crystalloids and albumin) during the procedure. Albumin is a costly blood product with limited supply, and its use varies widely. The goal was to describe current practices …

This study aimed to see if a special navigation system could help surgeons remove chest wall tumors more accurately. It was designed for adults scheduled for chest wall surgery. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study aims to see if a special PET-MRI scan using a tracer called FAZA can measure low oxygen (hypoxia) in pancreatic tumors. About 20 people with advanced pancreatic cancer that cannot be removed by surgery will get the scan before and after their standard radiation treatme…

This study looks at whether a special PET scan combined with MRI can measure low oxygen levels (hypoxia) in soft tissue sarcoma tumors. About 70 adults with high-risk sarcoma will receive an injection of a radioactive tracer called FAZA before their standard treatment. The goal i…