University Health Network, Toronto

This early safety trial tests a treatment called SYN002 on donor kidneys before transplant. The goal is to lower the risk of passing the common CMV virus from the donor organ to the recipient. About 12 adults waiting for a kidney transplant will take part. The main focus is wheth…

This study tests whether precisely targeted radiation can delay cancer progression in people with metastatic non-small cell lung cancer whose tumors begin to grow in a few spots while on targeted therapy. About 60 participants will receive stereotactic body radiation to those gro…

This early study tests whether giving a fecal transplant (FMT) to 20 patients with lymphoma or leukemia is safe and doable during CAR-T therapy or stem cell transplant. The goal is to see if enough patients can join and complete the treatment without serious side effects. If succ…

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in people with advanced soft tissue sarcoma that cannot be removed by surgery. The main goals are to find the safest dose and see how well the combination controls the cancer…

This study tests a new drug, asciminib, alone or with dasatinib, for adults with chronic myeloid leukemia (CML) whose first treatment stopped working. The goal is to see if this combination can better control the cancer. About 45 participants will be enrolled in this phase 2 tria…

This study tests whether adding the drug evofosfamide to a second hormone therapy can help control advanced prostate cancer that has stopped responding to initial treatment. About 35 men with castration-resistant prostate cancer that has spread will receive the drug combination. …

This study tests whether tamoxifen, a drug commonly used for breast cancer, can help men recover normal testosterone levels faster after finishing hormone therapy for prostate cancer. About 96 men who completed androgen deprivation therapy (ADT) will receive either tamoxifen or a…

This early-phase study tests the safety of a new form of curcumin (liposomal curcumin) in people with multiple myeloma that has returned or stopped responding to treatment. About 20 participants will receive the drug, with doses increasing in later groups to find the highest safe…

This study tests a new device that keeps donor hearts at the right temperature during transport, compared to the usual ice method. The goal is to see if it reduces severe complications after a heart transplant. About 50 adult heart transplant recipients will take part, and resear…

This study tests a personalized radiation approach for men whose prostate cancer has returned after surgery. Using PSMA PET scans, doctors will give higher radiation doses to areas with cancer and lower doses to healthy tissue. The goal is to reduce side effects while keeping tre…

This study tests if a nerve block injection in the neck can help people with long COVID symptoms like fatigue, brain fog, and dizziness. About 78 adults with long COVID will receive either the real injection or a sham (fake) one to see if it reduces symptoms. The goal is to find …

This study tests whether a 10-week virtual exercise program can reduce nerve pain and improve daily function in cancer survivors who have persistent nerve damage from chemotherapy. About 240 participants will either receive the exercise program plus health coaching or continue wi…

This study tests a therapy called CALM-TF to see if it can reduce traumatic stress in women with advanced ovarian cancer. About 300 women, either newly diagnosed or with a recurrence, will receive either CALM-TF sessions plus usual care or just usual care. Researchers will measur…

This study tests whether a newer type of spinal cord stimulation (called paresthesia-free) actually reduces chronic pain better than a placebo. About 90 adults with long-lasting nerve pain will receive both real and fake stimulation for 6 weeks each, without knowing which is whic…

This study tests whether adding pentoxifylline and vitamin E to standard cancer treatment can prevent lung injury (pneumonitis) in 150 adults with stage III non-small cell lung cancer. Participants will receive the drugs alongside chemoradiation and immunotherapy. The goal is to …

This study tests a program called Care and Connect, where trained volunteers help lung cancer patients find information, support, and resources. The goal is to see if the program is practical and helpful for reducing stress and improving well-being. About 50 adults with lung canc…

This study aims to train an artificial intelligence program to help anesthesiologists interpret stomach ultrasound images and tell whether a stomach is empty or full. Thirty healthy volunteers will have their stomachs scanned at three different times: after fasting, after eating …

This study looks at whether the natural variation in heartbeats (heart rate variability) can signal when a patient on high-flow oxygen therapy needs a flow adjustment. Researchers will gradually lower the oxygen flow in 20 adults already on this breathing support and monitor thei…

This study will see if data from an Apple Watch, combined with medical information, can predict when heart failure gets worse. About 360 adults with heart failure will wear an Apple Watch and do exercise tests. The goal is to find better ways to monitor heart health and prevent h…

This pilot study will test whether a heart health education program designed specifically for women can improve their knowledge, quality of life, and healthy habits. About 50 women with heart disease who are already in cardiac rehab will either get the special program plus usual …