Sound waves target brain tremor center in first-of-its-kind trial

This study tests whether low-intensity focused ultrasound (LIFUS) can reduce tremors and the feeling of falling in people with primary orthostatic tremor (POT), a rare condition where leg muscles shake when standing. Researchers will use MRI to guide sound waves to a deep brain area called the cerebellum, which is overactive in POT. Fifteen adults with confirmed POT will receive both real and sham (fake) stimulation to compare effects on tremor frequency, severity, and brain circuit changes.