Universitair Ziekenhuis Brussel

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men to restore sperm production. Five men who had fertility-threatening treatments as children will receive their own preserved tissue. The goal is to see if sperm can be found in…

This study is testing whether giving one dose of the immunotherapy drug pembrolizumab six weeks before surgery can help the immune system fight high-risk melanoma more effectively. About 49 adults with melanoma that hasn't spread on scans will receive the drug, then have their ly…

This study tests a new, less invasive procedure called superior rectal artery embolization (SRAE) for controlling bleeding from hemorrhoids. It involves blocking small arteries to stop bleeding without cutting or damaging the anal area. The study will enroll 80 adults with grade …

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study tests a new imaging agent (68GaNOTA-anti-MMR-VHH2) that attaches to certain immune cells (macrophages) in lung tumors. About 20 adults with non-small cell lung cancer scheduled for surgery will receive a PET scan with this tracer before their operation. The goal is to …

This study is testing whether giving healthy newborns a probiotic supplement (L. reuteri) can prevent colic and excessive crying. About 768 babies will receive either the probiotic or a placebo daily for the first 3 months. Researchers will track crying, fussiness, and stool patt…

This study tests whether a home-based, video-call program before knee replacement surgery helps people recover better. Forty adults scheduled for knee replacement will either get the program or standard advice. The goal is to see if the program is safe, doable, and improves pain,…

This phase 3 trial tests whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Sixty participants will follow the diet with guidance from a dietitian. The goal is …

This study tests whether a combined cognitive and motor training program done at home can improve memory and thinking in people with multiple sclerosis (MS). About 90 adults with MS will be randomly assigned to different training groups. The program uses telemedicine to guide exe…

This study looks at whether regular cardiovascular exercise (like walking, jogging, or cycling) can reduce the severity of irritable bowel syndrome (IBS) symptoms in adults who currently have a sedentary lifestyle. Researchers will enroll 30 participants aged 18-60 with moderate-…

This study looks at whether adding a nerve block to a standard steroid injection helps people with frozen shoulder feel less pain and move better. About 110 adults with frozen shoulder will get either the combo treatment or a steroid injection alone. The goal is to see if the ner…

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This study compares an AI algorithm (iDAScore) to human embryologists in ranking embryos for IVF. About 1,325 patients will have their embryos ranked either by the AI or by a specialist, then transferred one by one until a pregnancy is achieved. The goal is to see if the AI can m…

This study follows 100 people with COPD for one year to see how airway inflammation changes over time. Researchers use a simple breath test (FeNO) and a blood sample to measure inflammation. Participants visit the clinic three times: at the start, at 6 months, and at 12 months. T…

This study tests a tool called SWEET that predicts how long an ERCP procedure will take. Researchers will compare the tool's predictions to both the doctor's estimate and the actual time. The goal is to improve scheduling and reduce delays for patients needing this procedure to d…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study is creating a detailed database of 150 adults with faecal incontinence to better understand why some also have urinary incontinence (double incontinence). Researchers will compare medical history, symptoms, and results from a special anal pressure test. The goal is to …

This study is testing a new online food questionnaire to see if it can accurately measure what people eat, including FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults, both with and wit…

This study aims to find better blood tests to detect liver scarring (fibrosis) in people with chronic liver disease. Researchers will compare new markers in the blood with standard tests like FibroScan and liver biopsy. The goal is to improve early detection and monitoring of liv…

This study looks at whether adjusting magnesium levels in the dialysis fluid can reduce harmful inflammation and blood cell activation in people with end-stage kidney disease. Fifteen patients will have their dialysis fluid changed in different ways, and researchers will collect …

This study tracks people aged 5-39 who have antibodies linked to type 1 diabetes but no symptoms yet. Participants wear a continuous glucose monitor and take periodic sugar-drink tests for 2-3 years. The goal is to see if the monitor can predict when blood sugar problems begin, p…

This study aims to see if body composition (like muscle and fat levels) differs between women with functional dyspepsia (a condition causing stomach pain and fullness without a clear cause) and healthy women. About 40 women will have a quick, painless bio-electrical impedance sca…

This study looks at whether babies born with certain self-reactive antibodies are more likely to develop eczema. Researchers will test umbilical cord blood from 500 newborns—some with a family history of allergies or eczema, some without—and follow them for two years. The goal is…

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can give doctors extra information when monitoring asthma. Researchers will follow 50 adults with asthma who are changing their regular medication. Participants will take breathing tests and fil…

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study looks at whether a simple breath test can tell if people with moderate to severe irritable bowel syndrome (IBS) will feel better on a lactose-free diet. About 90 adults with IBS will take the breath test and then follow a lactose-free diet for 4 weeks. Researchers will…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study involves 200 adults having non-heart surgery under general anesthesia. Researchers will collect data from a standard muscle monitor to build a computer model that predicts when muscles fully recover from paralysis drugs. The goal is to improve safety and reduce complic…

This study looks at how well patients who have recently left the ICU absorb nutrients from tube feeding. By measuring the energy in patients' stool and their resting metabolism, researchers hope to understand if current feeding practices meet patients' needs. The goal is to impro…