Universitair Ziekenhuis Brussel

This study is testing whether giving one dose of the immunotherapy drug pembrolizumab before surgery can help the immune system fight high-risk melanoma more effectively. About 49 adults with melanoma that hasn't spread on scans will receive the drug six weeks before their lymph …

This study tests a new, less invasive procedure called superior rectal artery embolization (SRAE) for controlling bleeding from hemorrhoids. It involves blocking small arteries to stop bleeding without cutting or damaging the anal area. The study will enroll 80 adults with grade …

This study tests a new way to help men who became infertile after childhood cancer treatment. Doctors will take testicular tissue that was frozen before cancer therapy and transplant it back into the man's testicles. The goal is to see if this can restart sperm production and all…

This study tests a new CT scan that works without an ECG to quickly check for heart blockages, lung clots, or aortic tears in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive angiography to see if the new method is ac…

This study tests a new CT scan method to check for blocked heart arteries in people who survive a cardiac arrest. The scan uses existing images and special software, so no extra drugs or monitoring are needed. Researchers will compare the CT results with standard angiography to s…

This study tests a new imaging agent (68GaNOTA-anti-MMR-VHH2) that may help doctors see certain immune cells called macrophages in lung cancer tumors using a PET scan. About 20 adults with non-small cell lung cancer who are scheduled for surgery will receive the agent before thei…

This study is testing whether giving healthy newborns a probiotic supplement (L. reuteri) can prevent colic and excessive crying. About 768 babies will receive either the probiotic or a placebo daily for the first 3 months. Researchers will track crying, fussiness, and stool patt…

This study tests whether a home-based program before knee replacement surgery can help people recover faster and feel better prepared. About 40 adults scheduled for knee replacement will either get the program or standard advice. The goal is to see if the program is safe, doable,…

This study tests whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Researchers will enroll 60 adults and compare results to a lactose-free diet. The goal is to…

This study looks at whether regular cardiovascular exercise (like walking, jogging, or cycling) can reduce the severity of irritable bowel syndrome (IBS) symptoms in adults who currently have a sedentary lifestyle. Researchers will enroll 30 participants aged 18-60 with moderate-…

This study tests whether a combined cognitive and motor training program done at home can improve memory and thinking in people with multiple sclerosis (MS). About 90 adults with MS will be randomly assigned to different training groups. The program uses telemedicine to guide exe…

This study looks at whether adding a nerve block to a standard steroid injection helps people with frozen shoulder feel less pain and move better. About 110 adults with frozen shoulder will get either the combo treatment or a steroid injection alone. The goal is to see if the ner…

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This study aims to find better blood tests to detect liver scarring (fibrosis) in people with chronic liver disease. Researchers will compare new markers in the blood with standard tests like FibroScan and liver biopsy. The goal is to improve early detection and monitoring of liv…

This study compares an AI tool (iDAScore) to manual ranking by embryologists for selecting the best embryo to transfer in IVF. About 1,325 patients will have their embryos frozen and then transferred one by one based on either AI or human ranking. The goal is to see if both metho…

This study follows 100 people with COPD for one year to see how airway inflammation, lung function, and symptoms change over time. Researchers use a simple breath test (FeNO) and a small blood sample to measure inflammation. Participants attend three routine visits—at the start, …

This study looks at whether adjusting magnesium levels in the dialysis fluid can reduce harmful inflammation and blood cell activation in people with end-stage kidney disease. Fifteen patients will have their dialysis fluid changed in different ways, and researchers will collect …

This study tracks people aged 5-39 who have antibodies linked to type 1 diabetes but no symptoms yet. Participants wear a continuous glucose monitor and take periodic sugar-drink tests for 2-3 years. The goal is to see if the monitor can predict when blood sugar problems begin, p…

This study aims to see if body composition (like muscle and fat levels) differs between women with functional dyspepsia (a condition causing stomach pain and fullness without a clear cause) and healthy women. About 40 women will have a quick, painless bio-electrical impedance sca…

This study looks at whether babies born with certain self-reactive antibodies are more likely to develop eczema. Researchers will test umbilical cord blood from 500 newborns—some with a family history of allergies or eczema, some without—and follow them for two years. The goal is…

This study is creating a detailed database of 150 adults with faecal or double incontinence to better understand what factors contribute to each condition. Researchers will use advanced anorectal manometry and questionnaires to compare symptoms, medical history, and quality of li…

This study tests a new tool called SWEET that predicts how long an ERCP procedure will take. Researchers will compare the tool's predictions to those made by doctors and to the actual procedure time. The goal is to improve scheduling and reduce delays for patients and staff.

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can give doctors extra information when monitoring asthma. Researchers will follow 50 adults with asthma who are changing their regular medication. Participants will take breathing tests and fil…

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study looks at whether a simple breath test can tell if people with moderate to severe irritable bowel syndrome (IBS) will feel better on a lactose-free diet. About 90 adults with IBS will take the breath test and then follow a lactose-free diet for 4 weeks. Researchers will…

This study looks at how common high-grade anal lesions (a pre-cancer condition) are in HIV-negative men who have sex with men (MSM) using PrEP. About 300 participants will provide anal swabs and undergo a special exam called high-resolution anoscopy to check for these lesions. Th…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study is testing a new online food questionnaire to see if it can accurately measure what people eat, including FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults, both with and wit…

This study involves 200 adults having non-heart surgery under general anesthesia. Researchers will collect data from a standard muscle monitor to build a computer model that predicts when muscles fully recover from paralysis drugs. The goal is to improve safety and reduce complic…

This study looks at how well patients who have recently left the ICU absorb nutrients from tube feeding. By measuring the energy in patients' stool and their resting metabolism, researchers hope to understand if current feeding practices meet patients' needs. The goal is to impro…