Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This early-phase study tests a new cell therapy called CT1182 in 24 adults with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The main goals are to check safety, find the best dose, and see how well it shrinks tumors. Researchers will monitor side …

This study tests whether a procedure called TIPS (a small tube placed in the liver to improve blood flow) can help people with advanced liver disease (cirrhosis) achieve 'recompensation' — meaning their liver function improves and complications like fluid buildup or bleeding stop…

This early study tests an injection called IASO208 in 12 adults with relapsed or refractory B-cell blood cancers (like certain lymphomas). The main goal is to check safety and find the right dose, not to cure the disease. Participants must be between 18 and 75 years old and have …

This study tests a new drug called cizutamig in 28 people with severe rheumatoid arthritis that hasn't improved with other treatments. The main goal is to check if the drug is safe and to see early signs of how well it works. Participants will receive the drug and be closely moni…

This early study tests an experimental injection called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The main goals are to check safety and find the right dose. Researchers will also look at how the drug works in the body and if it he…

This early-phase study tests a new drug called YKST02 in 12 adults with IgA nephropathy, a kidney disease. The main goal is to see if the drug is safe and if it can reduce protein in the urine, a sign of kidney damage. Participants receive the drug by IV and are closely monitored…

This early-phase study tests a new drug called ZZSW-01 in 6 adults with B-cell blood cancers that have returned or not responded to prior treatments. The main goal is to check safety and side effects, including immune reactions. Researchers will also look for early signs that the…

This study tests whether injecting stem cells from umbilical cords can help people with knee osteoarthritis. The goal is to reduce pain and improve knee function, not to cure the disease. About 100 adults aged 40 to 70 will receive either the stem cells or a placebo, and research…

This study tests a combination of three drugs (IN10018, nab-paclitaxel, and cadonilimab) in women with a rare, hard-to-treat type of cervical cancer that has spread or come back. The goal is to see if this treatment can shrink tumors or slow the disease. About 25 adult women who …

This study tests whether adding the drug cadonilimab to standard chemotherapy and radiation can help people with locally advanced cervical cancer live longer without the disease getting worse. About 378 women aged 18-70 with stage IIB-IVA cervical cancer will be enrolled. The goa…

This early study tests a new drug called PRG-1801 in 6 adults with immune thrombocytopenia (ITP) that hasn't improved with standard treatments. The goal is to see if the drug is safe and can raise platelet counts to reduce bleeding risk. Participants receive a single infusion and…

This early-phase study tests a new type of cell therapy (called universal CD19/20 CAR-T) in 12 adults with moderate to severe lupus that hasn't responded to standard treatments. The main goals are to check safety and find the right dose. Researchers will also watch for signs that…

This early-phase study tests a new drug called A-319 in 12 adults with active rheumatoid arthritis who haven't responded well to standard treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and…

This early-phase study tests a new injection called OriV508 in 40 adults with multiple myeloma or non-Hodgkin lymphoma that has returned or not responded to standard treatments. The main goal is to check safety and find the right dose, while also looking at how well it works agai…

This study looks at 164 adults with cirrhosis (scarred liver) who also have severe muscle loss (sarcopenia) and need a procedure called TIPS to treat complications like bleeding. Half will get TIPS alone, and half will get TIPS plus branched-chain amino acid (BCAA) supplements. T…

This early-stage study tests a new treatment called RD06-05, a universal CAR-T cell therapy, in 27 adults with autoimmune blood diseases like immune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), or Evans syndrome. The therapy targets specific immune cells to reduce …

This early-stage study is testing a new drug called A-319 in 25 adults with active or treatment-resistant systemic lupus erythematosus (SLE). The drug is designed to target and help control overactive immune cells. The main goal is to check if it is safe and to see how the body r…

This early study tests a new treatment called universal CD19/20 CAR-T cells for people with moderate to severe lupus that hasn't responded to standard therapies. The treatment uses specially engineered immune cells to target and potentially reset the faulty immune system. The mai…

This study is for people with newly diagnosed, high-risk rectal cancer. It tests a treatment plan given before surgery that includes a short course of radiation, followed by a mix of chemotherapy and immunotherapy drugs. The goal is to shrink or eliminate the tumor, and for those…

This study tests whether fecal microbiota transplantation (FMT) can help treat delirium in intensive care unit (ICU) patients. Delirium is a serious confusion that affects up to 80% of ICU patients and can lead to long-term brain problems. The trial will give 60 adults with delir…

This early-phase study tests a new treatment called CT1195E CAR-T cells for people with severe systemic sclerosis (scleroderma) that hasn't responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and attack the disease. The ma…

This study tests if taking oral sorbitol (a common sugar alcohol) can make standard chemotherapy and immunotherapy work better for people with locally advanced stomach cancer. About 80 adults will receive either sorbitol or a placebo alongside their cancer treatment. The goal is …

This study is testing whether a phosphate supplement given as granules (by mouth or feeding tube) can safely raise low blood phosphate levels in 60 ICU patients. Participants will take the supplement daily for up to 14 days, with doses based on how low their phosphate is. The stu…

This early-phase study tests a new "universal" CAR-T cell therapy (CT1190B) for people aged 12 to 75 with B-cell acute lymphoblastic leukemia that has come back or not responded to standard treatment. The therapy is designed to target two markers on cancer cells (CD19 and CD20) a…

This study explores whether new types of PET scans can more accurately detect and stage kidney cancer (renal cell carcinoma). Researchers will test three different imaging agents in 66 adults with suspected or confirmed kidney cancer, as well as healthy volunteers. The goal is to…

This study is testing a new type of PET scan that uses a special tracer to find cancers like pancreatic, breast, lung, and others. The goal is to see if this scan can better detect and stage tumors compared to standard scans. About 26 adults with suspected or confirmed cancer, pl…

This study tests a new imaging agent called FL-091, which targets a protein (NTSR1) found on many cancer cells. By attaching a radioactive label, doctors can see tumors more clearly on PET or SPECT scans. The goal is to improve early diagnosis and staging of cancers like head and…

This study tests a new type of PET scan that looks for a protein called CLDN18.2 on cancer cells. It includes 56 adults with stomach, pancreatic, bile duct, or esophageal cancer, plus healthy volunteers. The goal is to see if this scan can accurately find tumors and help doctors …

This early-stage study is testing a new imaging agent called 68Ga-FL-031 for PET scans in people with certain cancers (small cell lung, breast, nasopharyngeal, and others). The goal is to see if this tracer can better identify tumors and their spread compared to standard FDG-PET.…

This early study is testing a new imaging agent called FL-261 to see if it can safely and accurately detect and stage several types of cancer, including lung, colorectal, and head & neck cancers. The agent targets a protein (c-MET) found on many cancer cells but not on most healt…

This study compares AI-assisted versus surgeon-only planning for placing screws in broken hips (femoral neck fractures). About 334 adults will be randomly assigned to one of the two methods. The goal is to see if AI helps improve screw placement accuracy, shorten surgery time, re…

This study tests whether moxibustion—a traditional therapy that burns herbs near the skin—can help people with severe gut problems after a stem cell transplant. About 42 patients whose graft-versus-host disease did not respond to steroids will receive standard drugs plus daily mo…

This study tests an investigational drug called ALT001 for knee osteoarthritis. About 30 adults aged 50 to 75 will receive either a low dose, high dose, or placebo injection into the knee every two weeks for six doses. The goal is to see if it reduces pain, improves joint functio…

This study looks at whether measuring two specific antibodies in the blood can predict which patients with viral myocarditis (heart muscle inflammation caused by a virus) will go on to develop dilated cardiomyopathy (a weakened, enlarged heart). Researchers will follow 300 adults…

This study looks at how nutrition affects the progression of bronchiectasis, a common lung disease. Researchers will measure things like arm and calf size, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung f…

This study looks at 300 liver cancer patients who cannot have surgery and are receiving a treatment called TACE. Researchers will use artificial intelligence to analyze routine CT scans taken before treatment, measuring body composition like organ size and tissue health. The goal…

This study looks at 150 adults with bronchiectasis, a long-term lung disease that causes coughing and breathing problems. Researchers want to understand how bacteria in the lungs and gut affect the disease and why some people get worse faster. They will collect sputum, stool, and…

This study looks at why a procedure called TIPS, which helps lower blood pressure in the liver, may also improve muscle loss (sarcopenia) in people with advanced liver disease. Researchers will measure a protein called FGF21 and muscle mass in 132 adults with cirrhosis before and…