Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This study tests whether adding a procedure called bronchial artery chemoembolization (which delivers chemotherapy directly to the tumor's blood supply) can improve outcomes for people with stage IV lung squamous cell carcinoma who have already had standard first-line chemotherap…

This study tests a new approach for people with a type of esophageal cancer that can be surgically removed. Before surgery, participants receive a short course of radiation, followed by three cycles of an immunotherapy drug (serplulimab) plus standard chemotherapy. The goal is to…

This study tests a new approach for people with locally advanced HER2-positive rectal cancer. Participants first receive short-course radiation, then a combination of three drugs: disitamab vedotin, sintilimab, and capecitabine. The goal is to see if this treatment can completely…

This study is for adults aged 18 to 65 with acute myeloid leukemia (AML) that has returned or not responded to treatment. Participants will receive a stem cell transplant from a half-matched donor, along with medicines and immune cells after transplant to try to prevent the cance…

This study tests penfluridol, a drug originally used for mental health, in 33 adults with advanced small cell lung or cervical cancer that has not responded to at least two prior treatments. The goal is to see if it can shrink tumors and control the disease. Participants take the…

This study tests a treatment plan for adults with severe immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding risk. Participants will receive a 14-day hospital treatment of high-dose steroids plus a platelet-boosting drug, follow…

This study tests whether fecal microbiota transplantation (FMT) — transferring healthy donor stool into the gut — can reduce deaths in ventilated ICU patients with multidrug-resistant lung infections. The idea is that restoring gut bacteria may help fight lung infections through …

This study tests whether adding a special type of radiation (quad shot radiotherapy) to a drug called QL1706 (which boosts the immune system) plus standard chemotherapy can better control advanced non-small cell lung cancer. About 104 people with stage IV lung cancer that has not…

This study tests whether a single injection of goserelin before a stem cell transplant can help preserve ovarian function in women with blood cancers. About 64 women aged 14-50 will be randomly assigned to receive goserelin or not. The main goal is to see if more women resume nor…

This early-phase study tests a new drug called QI-019A in 24 people with multiple myeloma that has returned or stopped responding to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look at whether the drug …

This study tests whether an AI-powered smartphone tool can help more people with chronic hepatitis B start antiviral treatment. Many people are diagnosed but never begin therapy due to fear, lack of awareness, or poor communication with doctors. The study will enroll 2000 adults …

This early-stage study tests a new gene therapy called LVIVO-TaVec400 in people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard treatments. The main goals are to check safety and find the right dose. About …

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the overactive immune system in people with moderate-to-severe ulcerative colitis or Crohn's disease. The study will enroll up to 30 adults w…

This study tests whether a single injection of goserelin before a stem cell transplant can help preserve ovarian function in women with blood cancers. 64 women aged 14-50 will be randomly assigned to receive goserelin or not, and their menstrual recovery will be checked 6 months …

This study tests whether adding metformin (a diabetes drug) to secukinumab (a standard psoriasis medication) works better than secukinumab alone for controlling moderate-to-severe plaque psoriasis in overweight or obese Chinese adults. About 186 participants will receive either t…

This study tests whether adding the drug serplulimab to standard induction chemotherapy can allow patients with advanced nasopharyngeal cancer to safely skip the intense concurrent chemotherapy that usually follows. The trial will enroll 456 adults aged 18-65 with previously untr…

This early-stage study tests a new cell therapy called YTS109 for people with autoimmune hemolytic anemia that hasn't improved after at least three prior treatments. The therapy uses specially designed immune cells to target and destroy the faulty cells causing the anemia. The ma…

This study tests whether giving two drugs—pembrolizumab and MRG-003—before standard chemoradiation can improve outcomes for people with advanced nasopharyngeal cancer linked to the Epstein-Barr virus. About 35 adults with stage III-IVa disease will receive the combination, then s…

This early-phase study tests a new treatment called QT-019C for adults with refractory immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The therapy uses specially engineered immune cells from a donor to target and remove fau…

This study tests whether a combination of three drugs (chidamide, venetoclax, and azacitidine) can help prevent acute myeloid leukemia (AML) from returning in patients who have already achieved complete remission after initial treatment. About 104 adults aged 18 to 80 will receiv…

This early study tests a new drug called YKST02, given alone or with another drug (YK012), in 30 adults with active or hard-to-treat lupus. The main goal is to see if the treatment is safe and tolerable. Researchers will also look for early signs that it helps control the disease…

This study tests a combination of two drugs, becotatug vedotin and zimberelimab, in 30 people with recurrent or metastatic cervical, vulvar, or vaginal cancer. The goal is to see if the treatment can shrink tumors and control the disease. Participants will receive the drugs for u…

This early study tests a new medicine called IN026 in 16 adults with refractory gout (gout that doesn't get better with standard treatments). The main goal is to check if the injection is safe and to see how the body handles it. Researchers will also measure if it lowers uric aci…

This study tests an experimental drug called IBI363 in 35 people with advanced small cell lung cancer that has worsened after at least two prior treatments, including immunotherapy. The goal is to see if IBI363 can shrink tumors or slow the disease. Participants will receive the …

This study looks at whether a single shot of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with severe aplastic anemia. The trial will enroll 132 women aged 14-50 who are scheduled for a stem cell transplant. Half will receive go…

This study tests a new type of PET scan (XH06) against standard MRI to see which better detects liver cancer. About 150 adults with suspected or confirmed liver cancer will receive both scans, and results will be compared to tissue samples. The goal is to improve diagnosis and st…

This early study will test a special imaging agent that targets a protein found on liver cancer cells. Six people with suspected or confirmed liver cancer will receive a low-dose radioactive tracer and then have a SPECT-CT scan. The goal is to see how the tracer moves through the…

This study will test an AI tool called AutoFUSE that helps doctors get better ultrasound images during early pregnancy. About 1,000 pregnant women will either get the AI-assisted scan or the usual scan. The goal is to see if the AI can make the scan faster and more accurate witho…

This study tests whether an artificial intelligence (AI) system can help radiologists interpret chest X-rays more accurately and quickly. About 16,000 adults with suspected lung conditions like pneumonia, tuberculosis, or lung cancer will take part. The AI is designed to assist d…

This study tests a new type of PET scan that uses a special probe to find cancers that have a protein called GPA33. The study will include 56 people with suspected or confirmed colorectal, stomach, or pancreatic cancer, as well as healthy volunteers. The goal is to see if this im…

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to receive radiation will use either the spray or a placebo for 12 months. The goal is t…

This study tests whether a special herbal mouthwash can prevent painful mouth sores caused by radiation therapy. About 156 adults with head and neck cancer will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if the mouthwash redu…

This study looks at how the immune system around nasopharyngeal tumors changes over time, especially after immunotherapy. Researchers will analyze samples from 600 patients to find which immune cells predict treatment success and why some tumors become resistant. The goal is to i…

This study aims to find markers in blood and lung scans that can predict how well patients with severe eosinophilic ACOS (a mix of asthma and COPD) will respond to biologic drugs like benralizumab, mepolizumab, or dupilumab. Researchers will follow 500 adults for 48 weeks after s…

This study will check if a non-invasive device called EIT Pulse Wave can accurately measure blood flow to the lungs and heart function in critically ill patients with shock or lung injury. Nineteen adults in the ICU who are on breathing machines and already have a standard heart …

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to uncover how…

This study looks back at data from 1,000 lung cancer patients with EGFR mutations who received targeted therapy after surgery. Researchers will use artificial intelligence to analyze CT scans, tissue samples, and genetic reports to build a model that predicts treatment success. T…