New combo therapy aims to stall advanced lung cancer
NCT ID NCT07567313
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a targeted chemoembolization procedure to standard immunotherapy can help people with stage IV lung squamous cell carcinoma live longer without their cancer growing. About 166 participants who have already responded to initial treatment will be randomly assigned to receive either immunotherapy alone or immunotherapy plus the procedure. The goal is to see if the combination improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Tislelizumab (immunotherapy) and bronchial artery chemoembolization (BACE, a procedure to deliver chemotherapy directly to lung tumors)
- What this could lead to
- If successful, this could offer a new treatment option that extends progression-free survival for people with advanced lung squamous cell carcinoma.
- What could go wrong
- This is an early-stage trial with only 166 participants, so results may not apply to everyone. The added procedure carries risks like bleeding or infection, and the benefit over standard immunotherapy alone is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 166 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Squamous cell carcinoma of the lung confirmed by histology or cytology; 2. According to the TNM staging system of the 9th edition of American Cancer Association, it was assessed as stage IV. 3. Has received standard first-line chemotherapy immunotherapy for 4\~6 cycles, and achieved partial remission or disease stability according to the efficacy evaluation of RECIST1.1; 4. The patient is 18-80 years old; 5. ECOG PS score is 0-1; 6. The main organ functions meet the following criteria: (1) Blood routine examination: hemoglobin (HB) ≥ 90g/L; Leukocyte (ANC) ≥ 3.0× 109/L; Neutrophils ≥ 1.5× 109/L; Platelet (PLT) ≥ 75× 109/L; (2) Biochemical examination: albumin (ALB)≥29g/L; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \< 2uln; Total bilirubin (TBIL) ≤ 1.5 ULN; Creatinine ≤ 1.5 ULN; 7. Patients and/or their families agree to participate in clinical trials and sign informed consent forms; 8. No history of other malignant tumors; 9. No active infection; 10. Be able to cooperate with research follow-up; 11. At least one measurable lesion (according to RECIST 1.1); 12. The expected survival time is more than 3 months. Exclusion Criteria: 1. There is epidermal growth factor receptor (EGFR) sensitive mutation or anaplasticlymphomakinase (ALK) gene translocation; 2. Have a history of allergy to contrast agents or chemotherapy drugs; 3. Received other anti-tumor treatments other than standard first-line chemotherapy immunotherapy; 4. Arrhythmia with myocardial ischemia or myocardial infarction above grade II and poor control (including QTc interval ≥450ms for men and ≥ 470 ms for women); 5. Coagulation function is seriously abnormal and cannot be corrected; 6. Hypertension patients still have poor blood pressure control (systolic blood pressure \> \>160mmHg, diastolic blood pressure \> 100 mmhg) after antihypertensive drugs treatment; 7. Pregnant or lactating female patients; 8. Have a history of mental illness or psychotropic drug abuse; 9. Patients with symptomatic brain metastasis; 10. Patients with autoimmune diseases;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.