Chu De Reims

This study tested whether a lower dose of botulinum toxin injections into the bladder works as well as the standard higher dose for children with nerve-related bladder overactivity. Researchers compared the two doses in 29 children aged 3-15 whose previous medications weren't wor…

This study tested if intensive care nurses could safely follow a new, detailed plan to help patients breathe without a ventilator (breathing machine). The plan used a bedside monitor to track the patient's exhaled air. Researchers wanted to see if this nurse-led approach was prac…

This study aimed to find a better way to diagnose and monitor small intestine neuroendocrine tumors (carcinoid tumors). Researchers compared different methods of measuring a key tumor marker called 5HIAA in both urine and blood. They tested whether a simpler overnight urine test …

This study tested a non-invasive laser scanning technique called Raman spectroscopy to measure skin thickening (fibrosis) in people with systemic sclerosis (scleroderma). Researchers compared scans from 26 scleroderma patients to scans from people without the disease over three y…

This study tested if measuring a protein called Aβ40 in spinal fluid, along with other known markers, could make diagnosing Alzheimer's disease more accurate. It involved 204 people with memory problems who were undergoing standard diagnostic tests. The goal was to see if this ne…

This study tested whether a special type of MRI scan, done soon after patients finished chemoradiation treatment for head and neck cancer, could predict if the cancer would come back. Researchers followed 59 patients to see if changes seen on this scan matched up with later cance…

This study tested a simple bedside method to help doctors decide if a critically ill patient needs IV fluids. Researchers monitored blood pressure changes while briefly raising a patient's legs to see if it predicted a beneficial response to fluids. The goal is to give fluids onl…

This study tested if a CT scan done one week after pancreas surgery could find hidden complications that doctors might otherwise miss. Researchers enrolled 80 patients who had scheduled pancreas surgery to see if this scan, done before sending patients home, could help predict pr…

This study tested which of two common pain control methods works better for patients recovering from total hip replacement surgery. Researchers compared a newer ultrasound-guided nerve block (called a PENG block) against the standard practice of the surgeon numbing the area durin…

This study tested whether a single osteopathic treatment session in the emergency department could help people with recent ankle sprains. 50 adults with a fresh sprain (within 72 hours) were randomly assigned to receive either standard medical care or an osteopathic consultation.…

This study tested whether using a virtual reality headset could help reduce pain and anxiety for patients receiving epidural injections for lower back and leg pain. 116 patients were randomly assigned to receive their first injection with VR and their second without, or vice vers…

This study aimed to understand how being born prematurely affects children's social development. Researchers compared 56 children born early (preterm) with those born full-term, focusing on their ability to understand others' thoughts and feelings. They also looked at how childre…

This study aimed to understand if specific genetic markers are linked to a severe eye complication called proliferative diabetic retinopathy in people with type 2 diabetes. Researchers compared 155 patients with this advanced eye disease to 155 patients without it, looking at the…

This study aimed to find out how often adults with specific weakened immune systems develop permanent lung damage called bronchiectasis. Researchers in France examined 46 adult patients with these immune conditions using CT scans and breathing tests. The goal was to understand wh…

This study aimed to understand how often cancer patients develop autoimmune side effects while taking a type of immunotherapy called checkpoint inhibitors. Researchers followed 183 adult patients starting this treatment for the first time, tracking specific antibodies in their bl…

This study aimed to understand the specific inflammatory process that drives hidradenitis suppurativa (HS), a chronic skin condition. Researchers examined small skin samples from 20 participants (10 with HS and 10 without) after surgery. The goal was to identify key immune signal…

This study aimed to understand why patients on long-term dialysis often develop serious blood vessel problems and heart disease. Researchers observed 100 dialysis patients to see if certain waste products in the body (called AGEs) and their receptor (RAGE) contribute to blood ves…

This study aimed to better understand the thought and speech patterns, like racing ideas or losing track, that occur in people with bipolar disorder. Researchers used brain scans (fMRI) to compare the brain activity of 79 people, including those with bipolar disorder and healthy …

This study aimed to better understand how patients with rheumatoid arthritis process their key medication, methotrexate. Researchers tracked the drug and its byproduct in the urine of 62 patients who were taking their weekly dose correctly. The goal was to establish a normal patt…

This study aimed to see how accurately different healthcare workers—senior doctors, resident doctors, and nurses—can assess a patient's pupils by eye. They compared these human assessments to measurements from a precise machine called a pupillometer. The goal was to identify any …

This study aimed to find a better way to screen for kidney disease in people with lupus. Researchers tested stored blood samples from 100 lupus patients to see if the presence of a specific antibody (anti-GBM) was linked to having lupus nephritis, a serious kidney complication. T…

This French study aimed to understand pregnancy denial—when a woman is unaware she is pregnant for months or the entire pregnancy. Researchers followed 130 mothers for 20 months to see how this experience affects the emotional bond with their child and the child's early developme…

This study aimed to understand if the natural aging of structural proteins in blood vessel walls plays a role in causing aortic aneurysms. Researchers analyzed tissue and blood samples from 24 patients who were already scheduled for surgery to repair an abdominal aortic aneurysm.…

This study followed 150 adults who recovered from severe COVID-19 pneumonia to see how many developed long-term lung complications. Researchers used chest CT scans to check for lasting lung damage months after the initial infection. The goal was to understand the lasting health i…

This study aimed to understand if a specific protein found in red blood cells is linked to a person's risk of developing Alzheimer's disease. It involved 200 Caucasian participants, some with Alzheimer's and some without. The research compared the characteristics of this protein …

This study aimed to understand why some young adults engage in binge drinking by examining their brain function, genetics, and psychological traits. Researchers studied 125 healthy young adults aged 18-25, using brain scans, genetic tests, and cognitive assessments. The goal was …

This study aimed to understand how problems with thinking skills and social understanding might contribute to alcohol use disorder. Researchers compared 216 people across three groups: those with alcohol use disorder, their close family members, and healthy volunteers. Participan…

This study aimed to better understand how hearing loss affects the tiny nerve connections in the inner ear. Researchers recorded electrical signals directly from the hearing nerve in 19 patients undergoing specific brain surgery. The goal was to gather detailed data to improve a …

This study aimed to understand how often specific genetic changes occur in people who have growths on both adrenal glands but no obvious symptoms of Cushing's syndrome. Researchers tested 150 adults with these incidental adrenal masses to look for mutations in a gene related to h…

This study aimed to understand how deep brain stimulation (DBS) treatment affects the way people with Parkinson's disease interpret social situations. Researchers worked with 32 French-speaking adults with Parkinson's to see if DBS changes a thinking pattern called 'attributional…

This study aimed to find a better way to measure frailty in people aged 65 and older who have cancer. Researchers tested if measuring fragments of a protein called elastin in the blood could provide a more objective and faster assessment than current methods. The goal was to help…

This study aimed to understand how early-stage Alzheimer's disease affects a person's ability to drive safely in real-world conditions. Researchers observed 60 older adults, half with early Alzheimer's and half without, while they drove. The goal was to identify common driving er…

This study tested whether a simple blood draw could detect cancer mutations in people with advanced melanoma. Researchers compared the blood test results to traditional tumor biopsies to see if they matched. The goal was to find a less invasive way to guide treatment decisions fo…

This study aimed to understand why children with acute lymphoblastic leukemia sometimes develop dangerous blood clots during treatment. Researchers followed 24 children to measure tiny cell particles in their blood that might trigger clotting. The goal was to learn more about the…

This study aimed to understand why some corneal transplants fail. Researchers examined tissue from 43 patients undergoing cornea surgery to see if a specific protein (CD160) is present in new blood and lymph vessels. The goal was to learn if this protein plays a role in the body …

This small, completed study aimed to understand the role of natural defense molecules called antimicrobial peptides in gum disease. Researchers compared mouth swabs from 29 healthy adults and those with moderate to severe chronic gum disease. The goal was to see if differences in…

This study aimed to find new blood markers that could help identify frailty in older adults before it leads to serious decline. Researchers analyzed blood samples from 254 participants aged 65 and older to measure specific proteins linked to aging. The goal was to create a better…

This study aimed to determine if bone density scan results should be interpreted differently for people with obesity. Researchers measured bone density twice in 120 participants with obesity, grouping them by body mass index. The goal was to see if the standard measurement thresh…

This study investigated whether certain long-lasting pesticide chemicals stored in body fat are associated with pancreatic cancer. Researchers compared fat tissue samples from 56 people—some with pancreatic cancer and some without—who were undergoing surgery. The goal was to gath…