Hidden gene mutations may explain some adrenal gland lumps
NCT ID NCT02810496
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study examined 150 adults who had accidentally discovered lumps on both adrenal glands, but no signs of Cushing's syndrome. Researchers checked for mutations in the glucocorticoid receptor gene to see if these genetic changes are more common than previously thought. The goal was to understand the link between gene mutations, hormone levels, and the size of the adrenal lumps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could reveal that certain gene mutations are a hidden cause of adrenal masses, leading to better diagnosis and possibly new treatment approaches.
- What could go wrong
- This is an observational study that only looks for gene changes; it does not test any treatment. The findings may not lead to direct benefits for patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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150 people
The number who actually took part.
- Started
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Apr 2012
- Finished
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Dec 2016
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patients more than 18 years of age * patients with bilateral adrenal masses Exclusion Criteria: * Refusing to participate in the study * Protected by law * Have obvious signs of Cushing's syndrome * No progressive neoplastic disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chu Reims
Reims, 51092, France