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Nurses take the lead: new protocol aims to speed breathing tube removal

NCT ID NCT05000034

Knowledge-focused Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a nurse-driven weaning protocol using capnography (a device that measures carbon dioxide in breath) could help safely remove breathing tubes faster in ICU patients. Fifty adults on ventilators for more than 48 hours were enrolled. Nurses followed a step-by-step plan to gradually reduce ventilator support, with capnography guiding decisions. The main goal was to see how well nurses could stick to the protocol, not yet to measure patient outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Weaning protocol (nurse-driven, capnography-guided)
What this could lead to
If successful, this could lead to a simpler, nurse-led method to safely remove breathing tubes sooner, reducing infections and hospital stays.
What could go wrong
This is a small, early feasibility study with only 50 patients. It focuses on whether the protocol can be followed, not yet on patient outcomes. Results may not apply to all ICUs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Feb 2021

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

inclusion criteria : * patients aged over 18 years and admitted in intensive care * invasive ventilation with assisted mode (assist-control or spontaneous with pressure support) for more than 48 hours, * stabilization of the cause of admission defined as: positive end-expiratory pressure level lower than or equal to 8 cm of water, a arterial oxygen saturation higher than 90 percent with a fraction of inspired oxygen lower than or equal to 50 percent for acute respiratory failure; infusions of norepinephrine less than or equal to 0,2 gamma/kg/min, no epinephrine or dobutamine for cardiogenic or septic shock; body temperature 36-38,5°C. exclusion criteria : * schedulded extubation within 24 hours after the inclusion, * schedulded surgery within week after the inclusion, * no available capnometer, * end stage chronic disease (cardiac, pulmonary, or renal), * "do not resuscitate order", * prior ventilation greater than 24 hours during the same hospitalization, * tracheostomy, * known or suspected severe myopathy or neuropathy, * severe chronic obstructive pulmonary disease, * pregnancy, * patients without medial care assistance. * conditions and/or circumstances that might result in difficulty to understand the informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weaning from mechanical ventilation

Contacts and locations

Locations

  • Damien JOLLY

    Reims, France

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