SPINAL CORD INJURY

This study tests whether adding robotic training with the Hunova device to standard rehabilitation helps people with spinal cord injury improve their trunk control (sitting balance and stability). About 78 participants will be assigned to standard rehab alone or standard rehab pl…

This study tests whether spinal cord stimulation can improve arm and hand function in people with tetraplegia (paralysis from the neck down) due to a chronic spinal cord injury. Researchers will use targeted electrical stimulation combined with motor training to help restore reac…

This study compares two treatments for arm and hand spasticity (muscle stiffness) caused by stroke, spinal cord injury, or brain injury. Thirty adults who already get Botox injections will also receive corrective surgery, allowing doctors to see which approach works better for ea…

This study tests whether a non-invasive spinal cord stimulation device can help people with chronic spinal cord injury improve autonomic functions like blood pressure, bladder, bowel, and sexual control. About 30 adults with complete paralysis at or above T6 will receive targeted…

This early-stage study tests whether a single injection of lab-grown nerve cells (made from stem cells) is safe for people with a recent spinal cord injury. The cells are designed to replace damaged nerve connections. The trial involves 12 adults with injuries between the neck an…

This early-stage trial tests a new device that delivers special cells (LCTOPC1) into the spinal cord of people with traumatic spinal cord injury. The goal is to replace or support damaged cells and help improve movement and quality of life. The study includes 10 adults with sever…

This study tests a surgically implanted device that uses small electrical currents to stimulate trunk and hip muscles in people with spinal cord injuries. The goal is to improve seated posture, balance, breathing, reaching, and wheelchair mobility. Ten participants with injuries …

This study tests a personal exoskeleton that lets people with spinal cord injury walk hands-free and stay balanced on their own. Researchers will check if the device is safe and helps users complete walking tasks like standing up, walking a short distance, and sitting down. The t…

This early study tests a device that sends mild electrical pulses to the spinal cord and limbs to help people with paralysis or weakness from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per week for a year, performing task…

This small pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training helps people with chronic spinal cord injury improve trunk control and walking. Twelve adults with incomplete injury will first receive robotic training alone, then …

This study is testing a treatment called ARC-IM Therapy, which uses a device placed near the spinal cord to send mild electrical pulses. The goal is to help people with recent or long-term spinal cord injury improve their ability to walk. The study will include 12 adults aged 18 …

This study tests whether a non-invasive spinal cord stimulation device can improve blood pressure control in 40 adults with chronic spinal cord injury. Researchers will place electrodes on the skin over the spine and stimulate different areas to see if it stabilizes blood pressur…

This study tests a device called SSMD to see if it helps adults with arm weakness from stroke or traumatic brain injury. About 150 participants will get either SSMD therapy plus standard rehab or standard electrical stimulation plus rehab. The goal is to measure improvements in a…

This study tests whether electrical stimulation of the spinal cord can improve walking ability and reduce pain in people with spinal cord injury. About 12 adults aged 20-70 who have had a spinal cord injury for over a year will receive a surgically implanted stimulator. The goal …

This study tests whether an implanted spinal cord stimulator can safely improve blood pressure, heart rate, and overall function in people with chronic cervical spinal cord injury. It involves 36 adults with stable, motor-complete injuries between the C4 and C7 vertebrae. The mai…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries (bedsores) in Veterans with spinal cord injury. Pressure injuries are common, painful, and costly for people with limited mobility and sensation. The tool includes a survey for Veterans and…

This study tests if gentle electrical stimulation of leg or lower back nerves can prevent bladder overactivity in people with a recent spinal cord injury. Researchers will compare two types of nerve stimulation to standard care in 45 adults. The goal is to stop bladder problems b…

This study tests whether mild electrical stimulation of the spinal cord can help improve bladder function in men with spinal cord injury. The goal is to increase urine flow and volume, making catheterization easier. The trial involves 24 participants who will attend testing sessi…

This study tests an online program called SCI&U that pairs people with spinal cord injury (SCI) with trained peer health coaches. The goal is to help participants manage their health, feel less distressed, and gain confidence after leaving the hospital. About 76 adults in British…

This study tests if a small electrical device worn on the skin near the genitals can help people with spinal cord injury control bowel accidents. Twelve adults will use the device at home for 6-8 hours daily over 4 weeks. Researchers will compare real stimulation to a placebo to …

This study tests whether psilocybin is safe for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spasms, and blood pressure changes over 13 months. The goal i…

This study tests whether adding a mild electrical stimulation to the lower back (called transcutaneous lumbosacral stimulation) during robotic exoskeleton walking helps people with chronic spinal cord injury walk farther and faster than using the exoskeleton alone. The study enro…

This early-stage study tests whether focused shockwave therapy can reduce arm and hand spasticity in people with spinal cord injury. Twelve participants will receive three weekly treatments, and researchers will measure changes in muscle stiffness, function, and quality of life. …

This study tests a robotic leg brace (exoskeleton) combined with mild electrical pulses to help people with brain injury, spinal cord injury, or multiple sclerosis walk better. Researchers will check if the device is safe and easy to use in 15 adults aged 18-80. The goal is to se…

This study tests whether short sessions of breathing lower oxygen (called low oxygen therapy) can improve blood pressure stability over 24 hours in people with chronic cervical spinal cord injury. Ten participants will undergo 4 days of treatment, and researchers will measure hea…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury (SCI) and chronic pain. Researchers will first adapt an existing mindfulness course for SCI needs, then test 1-2 modules using VR in 10 veterans. The goal is to see if…

This study tests whether a wearable robotic exoskeleton helps people with recent spinal cord injury regain walking ability better than standard physical therapy. Eighty participants will be randomly assigned to either robot-assisted or conventional gait training for 8 weeks. Rese…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to s…

This study tests whether a special vibrating capsule can safely help people with spinal cord injury who have trouble controlling their bowels. About 12 adults with chronic spinal cord injury will try the capsule as part of their regular bowel routine. The main goal is to see if t…

This study explores whether a 3-month pelvic floor muscle training program is practical and beneficial for people with motor-incomplete spinal cord injury. Researchers will track how many people join and stick with the program, any side effects, and whether it improves bladder, b…

This study looks at ways to treat sleep apnea in people who have had a cervical spinal cord injury for more than 6 months. Researchers will measure changes in breathing and sleep quality. About 100 adults aged 18 to 89 with chronic spinal cord injury (T6 and above) can join. The …

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can reduce stubborn nerve pain in people with spinal cord injuries. Researchers will compare two brain areas—the motor cortex and the anterior cingulate cortex—to see which provides better pain re…

This study tests whether a noninvasive brain stimulation technique, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. Researchers will compare the effects of real versus sham stimulation on hand muscle strength and control. The …

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it relieves pain and improves movement in people with spasticity (muscle tightness) after stroke, brain injury, or multiple sclerosis. It compares the freezing…

This study checks if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will track side effects and see if home use is practical.

This study tests whether giving calcitonin soon after a spinal cord injury can lower the chance or severity of nerve pain that often follows. Researchers will enroll 126 adults with recent spinal cord injuries and track their pain levels for up to a year. The goal is to see if ea…

This study tests a wearable suit called Neuro20 that uses mild electrical pulses to stimulate muscles and nerves. Researchers want to see if it can improve walking, muscle strength, and heart rate regulation in 30 adults who have had a spinal cord injury, stroke, or amputation. P…

This study tests whether a purified CBD medication (Epidiolex) can reduce urinary incontinence in people with a recent spinal cord injury. Twenty participants will take the drug daily for 90 days and track their bladder symptoms using a smartphone app. The goal is to see if CBD i…

This study is testing a portable, wearable exoskeleton that can stretch the legs and assist with walking for people who have muscle stiffness (spasticity) due to a spinal cord injury. Ten veterans will try the device during leg stretches, treadmill walking, and overground walking…

This study tests a treatment called cryoneurolysis, which uses controlled freezing to calm overactive nerves that cause pain and stiffness in people with brain or spinal cord conditions like stroke, multiple sclerosis, or injury. About 50 adults will be randomly assigned to get e…

This study tests a new smart bandage called exciflex that delivers gentle electrical therapy to help heal chronic wounds that won't close on their own. The study involves 16 veterans with diabetes or spinal cord injury who have wounds on their lower legs. The bandage is designed …

This study tests whether taking probiotics or prebiotics daily for eight weeks can reduce stomach and bowel problems in people with chronic spinal cord injury. Fifty participants will try both supplements at different times, with a break in between, to see which works better. The…

This early-stage study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for adults with spinal cord injury. Six participants will exercise for 20 minutes, eight times over six weeks. The goal is to see if this approach ca…

This study looks at whether measuring two proteins in the blood (NF-L and GFAP) soon after a spinal cord injury can help doctors predict how severe the injury will be six months later. Researchers will enroll 260 adults with traumatic spinal cord injuries and take blood samples d…

This early study is testing whether a combination of temporary electrical stimulation of the upper spine and magnetic stimulation of the brain can safely improve arm and hand function in people with cervical spinal cord injury. Twenty adults with incomplete injuries (levels C4 to…

This study tracks 8,000 people with spinal cord injuries across Europe to understand how the body naturally recovers. Researchers measure independence, walking ability, and nerve function over time. The goal is to create better tools for testing future treatments, not to test a n…

This study tests whether a brain stimulation training can improve the connection between the brain, spinal cord, and muscles in people with chronic cervical spinal cord injury. Researchers will use a non-invasive magnetic stimulator to measure and potentially strengthen these pat…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if this sensor can quickly detect dangerous drops in blood supply, which could lead to paralysis. The study involves 120 adults…

This study tests whether a remote training program can help manual wheelchair users improve their skills, confidence, and how often they perform key maneuvers. About 132 adults with spinal cord injuries will either receive remote coaching or be placed on a waitlist. The main goal…

This study tests a brain implant that records signals from the movement area and stimulates the sensory area. It aims to help 30 people with severe arm or hand impairment from spinal cord injury, stroke, or amputation control external devices like computers or robotic arms. The m…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study is developing a standard test to measure how well assistive technologies and brain-computer interfaces help people with severe motor impairments (like spinal cord injury or ALS) use computers and phones independently. Researchers will have 60 participants perform simul…

This study explores whether combining non-invasive brain and spinal cord stimulation during a thinking-and-moving task can improve sensation, movement, and thinking in people who have had a stroke or cervical spinal cord injury. About 45 participants (including healthy volunteers…

This study is testing a mobile health app designed to support the mental health and well-being of veterans with spinal cord injuries and their family caregivers. About 100 participants will help researchers adapt and improve the app by sharing their needs and feedback. The goal i…

This study watches and analyzes video recordings of occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to identify exactly what therapists do to help improve arm and hand function. The goal is to create a toolkit that makes reh…

This study looks at two different ways to use electrical stimulation to exercise the legs of people with spinal cord injury. One group does short bursts of high-intensity exercise, while the other does longer, easier exercise. The goal is to see which method improves fitness and …

This study collects feedback from people who already use upper limb assistive devices (like robotic arms or grasping gloves) in their daily lives. Through interviews and questionnaires, researchers aim to understand how these devices affect independence, satisfaction, and quality…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) know how often they should shift their weight to prevent pres…

This early study is testing whether a 10-week brain training program can improve arm and hand movement in people with chronic cervical spinal cord injury. Participants receive non-invasive brain stimulation and real-time feedback on their wrist muscle responses. The goal is to un…

This study looks at how a single dose of testosterone given as a nasal spray affects nerve signals and automatic body functions like heart rate in men with spinal cord injury. Many men with this injury have low testosterone, which may worsen nerve problems. The study will test 15…

This small study is testing whether combining electrical stimulation of a nerve in the leg with standing therapy can improve pelvic floor muscle function in adults with chronic spinal cord injury. Twelve participants will undergo 12 weeks of combined therapy and complete question…