PULMONARY ARTERIAL HYPERTENSION

This study tests whether sotatercept, a new drug that targets the root cause of blood vessel scarring in the lungs, can improve right heart function in people with pulmonary arterial hypertension (PAH). About 20 adults with moderate to severe PAH will receive injections every thr…

This study tests a drug called sotatercept in 42 children aged 1 to 17 who have pulmonary arterial hypertension (PAH), a serious lung condition. The goal is to see if the drug is safe and how the body processes it when added to standard care. This is not a cure, but it may help c…

This study looks at the long-term safety of the drug sotatercept when added to standard treatments for pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow, making breathing and activity difficult. About 815 adults who completed earlier sotatercept s…

This study tests a new medicine called IKT-001 for people with pulmonary arterial hypertension (PAH), a serious condition that makes it hard to breathe. About 486 adults aged 18 to 75 will receive either the drug or a placebo. The goal is to see if the drug improves blood flow in…

This study tests an experimental drug called APL-9796, given as injections under the skin, for people with pulmonary hypertension (high blood pressure in the lungs). The goal is to see if it is safe and tolerable, and whether it can improve blood flow and exercise ability. The tr…

This study tests whether spironolactone, a drug already used for fluid retention, can improve exercise ability and blood vessel health in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will take either spironolactone or a placebo for 24 weeks. Researc…

This early-stage study tests the safety of a new inhaled drug called L608, designed to treat pulmonary arterial hypertension (high blood pressure in the lungs). Researchers will give single increasing doses to 32 healthy adults aged 18 to 65 and monitor for side effects. The goal…

This early-stage study tests whether empagliflozin, a drug used for diabetes, can help people with pulmonary arterial hypertension (PAH). PAH causes high blood pressure in the lungs, making it hard to breathe. About 72 adults will take either empagliflozin or a placebo daily for …

This study tests whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves their walking distance and heart function.…

This study tests a new device for people with pulmonary hypertension, a condition where high blood pressure in the lungs strains the heart. The device is implanted to help the heart pump blood more easily. The study will check if the device is safe and works well in 30 adults wit…

This early study tests a small device called the V-Wave shunt in 20 people with severe pulmonary arterial hypertension (PAH). The shunt is placed in the heart to relieve pressure on the right side. The main goal is to check safety and see if it might improve symptoms and exercise…

This study gives continued access to the inhaled drug TPIP for people with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (PH-ILD). Only those who finished earlier open-label studies of TPIP can join. The goal is to keep provid…

This study is testing whether a special MRI using 129 xenon gas can help doctors see and track changes in the lungs of people with pulmonary arterial hypertension (PAH), a serious condition where blood vessels in the lungs narrow. About 20 adults with PAH will have MRI scans alon…

This study tests a special PET scan that uses a tracer called 18F-fluoroglutamine to see if it can detect early signs of pulmonary arterial hypertension (PAH), a serious lung blood vessel disease. About 71 adults with or at risk for PAH will get the scan to measure how the tracer…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step count. Fifty teens aged 10-21 will use a Fitbit and receive coaching to boost activity over 12 weeks. The goal is to improve exercise and quality o…

This study tests whether a 12-week group exercise program can improve exercise capacity, quality of life, and daily activity in adults with pulmonary arterial hypertension (PAH), a rare lung condition. Twenty participants with stable disease will take part in outpatient rehab ses…

This study looks at whether starting a 12-week home exercise program soon after diagnosis can improve how far patients with pulmonary hypertension can walk, their quality of life, and their mental health. About 40 adults will take part, with some starting exercise right away and …

This study aims to find genetic factors linked to pulmonary hypertension (high blood pressure in the lungs). Researchers will collect health surveys and saliva samples from 10,000 US adults aged 18 and older, both with and without the condition. Participation is online and takes …

This study tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and possible for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will be randomly assigned to receive either the bacteria transplant or a place…

This study aims to find genes that make some people with congenital heart defects more likely to develop pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will test the DNA of 21 participants who have both a heart defect and PAH. The goal is to use gene…

This study looks at what happens when people with pulmonary arterial hypertension (PAH) switch from one medication (ambrisentan) to another (bosentan). Researchers will track 121 adults over 3-6 months to see if their risk scores, symptoms, and lab results change. The goal is to …

This study is a national registry that collects information from 3,000 people with pulmonary hypertension (PH) treated at specialized centers across the U.S. Researchers will track how patients are diagnosed and treated, and follow them over time to see what factors lead to bette…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI scans with lung tissue from 30 patients awaiting lung transplants. The goal is t…

This study aims to understand why diagnosing pulmonary arterial hypertension (PAH), a rare and serious lung disease, often takes a long time. Researchers will review medical records from 139 adults in Brazil to track how long symptoms go unnoticed and how many doctors are seen be…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study tests whether a special type of MRI, using inhaled xenon gas, can show how well the drug sotatercept is working in people with pulmonary arterial hypertension (PAH). PAH is a serious condition where blood vessels in the lungs narrow, making the heart work harder. The s…