PULMONARY ARTERIAL HYPERTENSION

This study looks at the safety and right dose of selexipag for children aged 2 to 17 with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard for the heart to pump blood. About 63 children will take the drug to see if it works like it does in adults…

This study tests a new drug called Oxacom® in 260 adults with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is too high. The goal is to see if different doses can improve blood flow and are safe compared to a placebo. Participants either hav…

This study tests a new medicine, PF-07868489, first in healthy adults to check safety and how the body processes it, then in people with pulmonary arterial hypertension (PAH) to see if it helps lower blood vessel resistance in the lungs. About 97 participants will take either the…

This study looked at the safety of an implantable catheter and pump system that delivers a medication called Remodulin directly into the body for people with pulmonary arterial hypertension (PAH). The study enrolled 64 participants. Development of the system has stopped, but the …

This study tests whether empagliflozin, a drug already used for diabetes, can improve right heart function in 78 adults with pulmonary arterial hypertension (PAH). Participants continue their usual PAH medications and are randomly assigned to receive either empagliflozin or a pla…

This study looks at whether a healthy diet and exercise program can help people with pulmonary arterial hypertension (PAH), a serious lung condition. The idea is that improving how the body handles sugar (insulin sensitivity) might also improve blood flow in the lungs. About 34 a…

This study looks at the long-term safety and tolerability of an inhaled powder called treprostinil palmitil (TPIP) for people with pulmonary arterial hypertension (PAH). Participants who completed earlier TPIP studies can join and continue treatment. The main goal is to track sid…

This study looks at the long-term safety of an inhaled medication called GB002 for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants had already taken GB002 in an earlier study and will continue treatment while…

This study tests whether a higher dose (75 mg) of the drug macitentan works better than the usual dose (10 mg) at preventing serious events like hospitalization or death in people with pulmonary arterial hypertension (PAH). About 935 adults with PAH will take either the higher or…

This study tests the safety of an inhaled medication called L606 for people with high blood pressure in the lungs (pulmonary arterial hypertension or pulmonary hypertension from lung disease). About 28 adults will switch to or start L606 and be monitored for side effects over wee…

This study is a patient registry that follows 300 adults with pulmonary arterial hypertension (PAH) who are starting or recently started Orenitram. Researchers will track how well people tolerate the drug, how it affects their daily function, and any side effects over 78 weeks. T…

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study looks at the long-term safety and effectiveness of an inhaled medication called seralutinib for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 316 adults who finished a previous seralutinib study will ta…

This study tests a drug called satralizumab in 20 adults with pulmonary arterial hypertension (PAH) who have high levels of the inflammatory marker IL-6 and haven't responded well to standard treatments. The main goal is to see if the drug improves blood flow in the lungs over 24…

This study tests whether starting treprostinil early and increasing the dose quickly can lower blood pressure in the lungs and improve right heart function in people with pulmonary arterial hypertension (PAH). About 52 adults with PAH will receive the treatment and be followed fo…

This study looks at the long-term safety of a medicine called sotatercept for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 130 adults who completed a previous study will receive weight-based doses of sotatercept …

This study looks at whether different types of exercise training can help people with Pulmonary Arterial Hypertension (PAH) feel better and have a better quality of life. Researchers are comparing whole-body aerobic training with leg-only weight training in 45 participants. The g…

This study looks at whether low-resistance exercise training is safe and can help improve frailty and quality of life in people with pulmonary arterial hypertension (PAH). About 20 adults with stable PAH will take part. Researchers will track safety, how well people stick with th…

This study looks at whether Pulmonary Arterial Hypertension (PAH) causes problems with thinking, memory, and attention. Researchers will compare 30 PAH patients with 30 healthy volunteers using computer-based brain games. The goal is to better understand how PAH affects the brain…

This study follows two small groups of pregnant women in Bolivia living above 3,500 meters: healthy women and those with complications like preeclampsia. Researchers measure heart function, blood vessel changes, and baby growth to understand how high altitude affects pregnancy. T…

This study aims to better understand pulmonary hypertension by analyzing the genes, molecules, and cells of 1,195 participants with various heart and lung conditions. The goal is to create more precise definitions of the disease and identify new biomarkers. This research does not…

This study aimed to see if a non-invasive device (ClearSight) can accurately measure how well the heart pumps blood in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Researchers planned to compare these readings with st…