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Lung condition may affect brain function, new study hints

NCT ID NCT07391228

Knowledge-focused Sponsor: Alessandra Gorini Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether people with pulmonary arterial hypertension (PAH) have changes in thinking skills like memory and attention. Researchers will compare 30 PAH patients to healthy volunteers using computer-based tests. The goal is to better understand how PAH might affect the brain, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal specific thinking and memory problems linked to PAH, guiding future treatments or monitoring.
What could go wrong
This is a small, early observational study with only 30 participants. It cannot prove cause or lead directly to a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be recruited consecutively from among those with a confirmed diagnosis of PAH admitted to the U.O. Cardiologia Riabilitativa of the IRCCS Maugeri - Milano. Healthy controls will be identified on a voluntary basis among IRCCS Maugeri staff, healthy family members of patients, or through other authorised internal channels. Participation in the study will be voluntary and subject to the signing of an informed consent form.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria - PAH patients: * Confirmed diagnosis of Pulmonary Arterial Hypertension * Age ≥ 18 years; * Ability to understand instructions and give informed consent; * Absence of neurological and psychiatric comorbidities; * Stable clinical condition, according to the treating physician's judgement; * Willingness to participate in the study for the entire duration of the tests. Inclusion criteria - Healthy controls: * Matching for age (± 3 years), gender, manual laterality and level of education: * No current or past organic and/or psychiatric disorders. Exclusion criteria for both groups: * Presence of medical, neurological or psychiatric comorbidities that could interfere with cognitive performance; * Use of drugs known to affect cognitive function; Presence of sensory and/or motor deficits that could compromise test performance; Insufficient understanding of spoken and/or written Italian; Inability to give free and/or informed consent.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulmonary arterial hypertension

Contacts and locations

Locations

  • IRCCS Maugeri - Milano

    Milan, Italy, 20138, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.