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Higher dose of PAH drug may keep patients out of hospital longer

NCT ID NCT04273945

Disease control Sponsor: Actelion Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This phase 3 trial compares two doses of macitentan (75 mg vs 10 mg) in about 935 adults with pulmonary arterial hypertension. The goal is to see if the higher dose can delay serious events like hospitalization or death. Participants will be followed for several years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Macitentan (a drug to treat pulmonary arterial hypertension)
What this could lead to
If successful, this could show that a higher dose of macitentan is more effective at delaying serious complications or death in people with pulmonary arterial hypertension.
What could go wrong
This is an early-stage comparison of two doses of an existing drug, not a new treatment. The higher dose may cause more side effects without providing extra benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

935 people

The number who actually took part.

Started

Jun 2020

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Target population: greater than or equal to (\>=) 18 (or the legal age of consent in the jurisdiction in which the study is taking place) years of age * Target population: Symptomatic Pulmonary Arterial Hypertension (PAH) in World Health Organization Functional Class (WHO FC) II, III, or IV * Target population: PAH subtype falling in one of the below classifications: Idiopathic; Heritable; Drug- or toxin-induced; Related to: Connective tissue disease, HIV infection, Portal hypertension, and Congenital heart disease with small/coincidental cardiac defect with systemic-to-pulmonary shunt (for example atrial septal defect, ventricular septal defect, patent ductus arteriosus, atrioventricular septal defect) which does not account for the elevated pulmonary vascular resistance (PVR) or persistent PAH documented by an Right heart catheterization (RHC) \>= 1 year after simple systemic-to pulmonary shunt repair * PAH diagnosis confirmed by hemodynamic evaluation at rest at any time prior to screening: Mean pulmonary artery pressure (mPAP) greater than (\>) 20 millimeters of mercury (mm Hg), and; Pulmonary artery wedge pressure (PAWP) or left ventricular end diastolic pressure (LVEDP) less than or equal to (\<=) 15 mm Hg, and PVR \>= 3 Wood Units (that is, \>= 240 dyn\*sec/cm\^5) * Able to perform the 6-minute walking test (6MWT) with a minimum distance of 50 meters (m) and maximum distance of 440m at screening. Participants able to walk more than 440m at screening are eligible if they are in WHO FC III or IV and n-terminal prohormone of brain natriuretic peptide or n-terminal pro B-type natriuretic peptide (NT-proBNP) level is \>=300 nanograms per liter (ng/L) at screening, based on central laboratory results Exclusion Criteria: * Known presence of three or more of the following risk factors for heart failure with preserved ejection fraction at screening, based on records that confirm documented medical history: Body mass index (BMI) \> 30 kilograms per meter square (kg/m\^2), Diabetes mellitus of any type, Essential hypertension (even if well controlled); Coronary artery disease, that is, any of the following: history of stable angina, or known more than 50 percent (%) stenosis in a coronary artery, or history of myocardial infarction, or history of or planned coronary artery bypass grafting and/or coronary artery stenting * Presence of moderate or severe obstructive lung disease (forced expiratory volume in 1 second \[FEV1\] / forced vital capacity \[FVC\] \< 70%; and FEV1 \< 60% of predicted after bronchodilator administration) ) in participants with a known or suspected history of significant lung disease as documented by a spirometry test performed within 1 year prior to screening * Known moderate to severe hepatic impairment, defined as Child-Pugh Class B or C, based on records that confirm documented medical history * Serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) \> 1.5\*upper limit of normal (ULN) at screening * Hemoglobin \< 100 gram per liter (g/L) (\< 10 gram per deciliter \[g/dL\]) at screening

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulmonary arterial hypertension

Contacts and locations

Locations

  • AOU Di Modena Policlinico Di Modena

    Modena, 41125, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Adana City Hospital

    Adana, 01170, Turkey (Türkiye)

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453, United States

  • Ahepa University General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • Akdeniz University Medical Faculty

    Antalya, 07059, Turkey (Türkiye)

  • Akershus Universitetssykehus

    Nordbyhagen, 1478, Norway

  • Alexandra General Hospital of Athens

    Athens, 11528, Greece

  • Allegheny General Hospital of Research

    Pittsburgh, Pennsylvania, 15212, United States

  • Altay Regional Cardiological Dispensary

    Barnaul, 656055, Russia

  • AnMed Health

    Anderson, South Carolina, 29621, United States

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800, Turkey (Türkiye)

  • Ankara Etlik Speciality Hospital

    Ankara, 06170, Turkey (Türkiye)

  • Aphm - Hopital Nord

    Marseille, 13915, France

  • Arizona Pulmonary Specialists, Ltd

    Scottsdale, Arizona, 85258, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • B.D. Mehta Mahavir Heart Institute

    Surat, 395001, India

  • Baylor College of Medicine (BCM) - Baylor Heart Clinic

    Houston, Texas, 77030, United States

  • Baylor Scott White - Plano

    Plano, Texas, 75093, United States

  • Beijing Anzhen Hospital

    Beijing, 100029, China

  • Beijing Chaoyang Hospital

    Beijing, 100020, China

  • Bursa Yuksek Ihtisas Training and Research Hospital

    Bursa, 16310, Turkey (Türkiye)

  • CHRU de Lille Hopital Claude Huriez

    Lille, France

  • CHU Saint Etienne Hopital Nord

    Saint-Priest-en-Jarez, 42277, France

  • CHU de Brest - Hopital de la Cavale Blanche

    Brest, 29200, France

  • CNE 'Cherkasy Regional Cardiological Center of Cherkasy Regional Council'

    Cherkassy, 18000, Ukraine

  • CNE' City Clinical Hospital #8' of Kharkiv City Council

    Kharkiv, 61176, Ukraine

  • Care Hospitals

    Hyderbad, 500034, India

  • Carmel Medical Center

    Haifa, 34362, Israel

  • Centre Hospitalier Universitaire - de Nice - Hopital Pasteur

    Nice, 06002, France

  • Centro Cardiovascular Colombiano Clínica Santa María

    Medellín, 681004, Colombia

  • Centro Médico Dra. De Salvo

    Caba, C1426ABP, Argentina

  • Centro de Investigacion Clinica Chapultepec

    Morelia, 58260, Mexico

  • Cepes - Fmabc

    São Paulo, 09060-870, Brazil

  • Ceti - Centro de Estudos Em Terapias Inovadoras

    Curitiba, 80060-240, Brazil

  • Chelyabinsk Regional Clinical Hospital

    Chelyabinsk, 454076, Russia

  • Cho Ray Hospital

    Ho Chi Minh City, 700000, Vietnam

  • Cims Hospital

    Ahmedabad, 381060, India

  • Cleveland Clinic

    Weston, Florida, 33331 3609, United States

  • Clínica Imbanaco S.A.S.

    Cali, 760042, Colombia

  • Columbia University

    New York, New York, 10032, United States

  • Communal Noncommercial Enterprise Cherkasy Regional Hospital of Cherkasy Regional Council

    Cherkasy, 18009, Ukraine

  • Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'

    Lviv, 79010, Ukraine

  • Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez

    Guadalajara, 44657, Mexico

  • Cukurova University Medical Faculty

    Adana, 01790, Turkey (Türkiye)

  • Dokuz Eylul Universitesi Tip Fakültesi Hastanesi

    Izmir, 35330, Turkey (Türkiye)

  • Dr Kalla

    Lenasia, 1820, South Africa

  • Duke

    Durham, North Carolina, 27710-4000, United States

  • Ege Universitesi Tip Fakultesi Hastanesi

    Izmir, 35100, Turkey (Türkiye)

  • Empresa Brasileira de Servicos Hospitalares-EBSERH-Hospital Universitario de Brasilia

    Brasília, 70840-901, Brazil

  • Erasmus MC

    Rotterdam, 3015 CN, Netherlands

  • Fiona Stanley Hospital

    Murdoch, 6150, Australia

  • Flinders Medical Centre

    Bedford Park, 5042, Australia

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fondazione Toscana Gabriele Monasterio CNR

    Pisa, 56124, Italy

  • Freeman Hospital

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Fujita Health University Hospital

    Toyoake, 470-1192, Japan

  • Fundacion Cardiovascular de Colombia

    Bucaramanga - Piedecuesta - Valle de Menzuli, 6810002, Colombia

  • Fundacion Neumologica Colombiana

    Bogotá, 1101131, Colombia

  • GB Pant Institute of Post Graduate Medical Education & Research

    New Delhi, 110002, India

  • Gazi University Medical Faculty

    Ankara, 06500, Turkey (Türkiye)

  • General University Hospital II.department of Internal Medicine-cardiology and angiology

    Prague, 128 08, Czechia

  • Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet Felnott kardiologiai osztaly

    Budapest, 1096, Hungary

  • Govindaswamy Kuppuswamy Naidu Memorial Hospital

    Coimbatore, 64103, India

  • Grupo ELORA Centro de Pesquisa e Ensino em Saude de Santa Catarina

    Florianópolis, 88020 210, Brazil

  • Hacettepe University Medical Faculty

    Ankara, 06230, Turkey (Türkiye)

  • Hanoi Medical University Hospital

    Hanoi, Vietnam

  • HealthWorld Hospitals

    Durgapur, 713216, India

  • Hokkaido University Hospital

    Sapporo, 060-8648, Japan

  • Hopital Bicetre Aphp Hopitaux Universitaires Paris Sud

    Le Kremlin-Bicêtre, 94270, France

  • Hopital Larrey CHU de Toulouse

    Toulouse, France

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Costa Del Sol

    Málaga, 29603, Spain

  • Hosp. Del Mar

    Barcelona, 8003, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Pta. de Hierro Majadahonda

    Madrid, 28222, Spain

  • Hospital Das Clinicas Da Faculdade De Medicina Da USP

    São Paulo, 05403-000, Brazil

  • Hospital De Clinicas De Porto Alegre

    Porto Alegre, 90035 903, Brazil

  • Hospital Italiano de Buenos Aires

    Caba, 1199ABB, Argentina

  • Hospital Pulau Pinang

    George Town, 10990, Malaysia

  • Hospital Serdang

    Kajang, 43000, Malaysia

  • Hospital Universidad del Norte

    Soledad, 0000000, Colombia

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Monterrey, 64460, Mexico

  • Hospital das Clinicas - UFG

    Goiânia, 74605 020, Brazil

  • Hôpital Côte de Nacre

    Caen, France

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Institut Jantung Negara (National Heart Institute)

    Kuala Lumpur, 50400, Malaysia

  • Institute for Pulmonary Disease of Vojvodina

    Kamenitz, 21204, Serbia

  • Instituto Cardiovascular de Rosario

    Rosario, S2000DSR, Argentina

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, 04012-909, Brazil

  • Instituto Medico de La Fundacion Estudios Clinicos

    Rosario, 2000, Argentina

  • Instituto Nacional de Cardiologia Dr. Ignacio Chavez

    Mexico City, 14080, Mexico

  • Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

    Belo Horizonte, 30441-070, Brazil

  • Instituto de Cardiologia de Corrientes

    Corrientes, W3400AMZ, Argentina

  • Instituto de Medicina Integral Professor Fernando Figueira

    Recife, 50070-902, Brazil

  • Integris Baptist Office

    Oklahoma City, Oklahoma, 73112, United States

  • Jawaharlal Institute of Postgraduate Medical Education and Research

    Puducherry, 605008, India

  • Jeffrey S. Sager, MD Medical Corporation

    Santa Barbara, California, 93105, United States

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kagoshima University Hospital

    Kagoshima, 890 8520, Japan

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • Kaplan Medical Center

    Rehovot, 76100, Israel

  • Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi

    Kartal Istanbul, 34865, Turkey (Türkiye)

  • King Fahad Medical City

    Riyadh, 59046, Saudi Arabia

  • King Faisal Specialist Hospital & Research Center

    Riyadh, 11564, Saudi Arabia

  • Kobe University Hospital

    Kobe, 650 0017, Japan

  • Krakowski Szpital Specjalityczny im Jana Pawla II Oddzial Kliniczny Chorob Serca i Naczyn

    Krakow, 31 202, Poland

  • Kure Kyosai Hospital

    Hiroshima, 737-8505, Japan

  • Kurume University Hospital

    Kurume, 830-0011, Japan

  • Kyoto University Hospital

    Kyoto, 606 8507, Japan

  • Kyushu University Hospital

    Fukuoka, 812 8582, Japan

  • LKH-Univ. Klinikum Graz

    Graz, 8036, Austria

  • Lankenau Medical Center

    Wynnewood, Pennsylvania, 19096, United States

  • Lindner Clinical Trial Center/Christ Hospital

    Cincinnati, Ohio, 45219, United States

  • Louisiana State University

    New Orleans, Louisiana, 70112 7021, United States

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502-2006, United States

  • MI 'Dnipropetrovsk Regional Clinical Center of Cardiology and Cardiac Surgery'

    Dnipro, 49070, Ukraine

  • Mackay Memorial Hospital

    Taipei, 10449, Taiwan

  • Maharaj Nakorn Chiang Mai hospital Faculty of Medicine

    Chiang Mai, 50020, Thailand

  • Marmara University Medical Faculty

    Istanbul, 34899, Turkey (Türkiye)

  • Mayo Clinic

    Phoenix, Arizona, 85054, United States

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical University Vienna

    Vienna, 1090, Austria

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Medizinische Klinik und Poliklinik V Klinikum Grosshadern der LMU

    München, 81377, Germany

  • Mersin University Medical Faculty

    Mersin, 33110, Turkey (Türkiye)

  • Milpark Hospital

    Johannesburg, South Africa

  • Minsk Regional Clinical Hospital

    Minsk, 220143, Belarus

  • Moscow City Clinical Hospital No.51

    Moscow, 121309, Russia

  • Mount Sinai

    New York, New York, 10029, United States

  • Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead

    Sofia, 1309, Bulgaria

  • Municipal Non-commercial Enterprise Ternopil University Hospital of Ternopil Regional Council

    Ternopil, 46002, Ukraine

  • NHL Medical College (SVP Hospital IMSR)

    Ahmedabad, 380006, India

  • Nagasaki University Hospital

    Nagasaki, 852-8501, Japan

  • Nagoya City University Hospital

    Nagoya, 467 8602, Japan

  • Nagoya University Hospital

    Nagoya, 466 8560, Japan

  • Narayana Hrudayalaya Limited

    Bangalore, 560099, India

  • Narodny ustav srdcovych a cievnych chorob

    Bratislava, 833 48, Slovakia

  • National Cerebral and Cardiovascular Center

    Suita-Shi, 564-8565, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Heart Centre (NHC) Singapore

    Singapore, 169609, Singapore

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192, Japan

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • National Medical Research Center of Cardiology of MoH of Russian Federation

    Moscow, 121552, Russia

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • National University Heart Centre, Singapore

    Singapore, 119228, Singapore

  • National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation

    Saint Petersburg, 197341, Russia

  • Niigata University Medical And Dental Hospital

    Niigata, 951 8520, Japan

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Norton Pulmonary Specialists

    Louisville, Kentucky, 40202, United States

  • Okayama University Hospital

    Okayama, 700 8558, Japan

  • Operadora de Hospitales Angeles SA de CV Hospital Angeles Lomas

    México, 52787, Mexico

  • Ordensklinikum Linz GmbH Elisabethinen

    Linz, 4020, Austria

  • Oregon Health And Science University

    Portland, Oregon, 97239-3011, United States

  • Oslo University Hospital

    Oslo, 372, Norway

  • Ospedale San Francesco

    Nuoro, 08100, Italy

  • Pamukkale Universitesi Tip Fakultesi Hastanesi

    Denizli, 20160, Turkey (Türkiye)

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji

    Warsaw, 02 507, Poland

  • Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar

    Pécs, 7624, Hungary

  • Peking Union Medical College Hospital

    Beijing, 100730, China

  • Phramongkutklao Hospital and Medical College

    Bangkok, 10400, Thailand

  • Piedmont Healthcare

    Atlanta, Georgia, 30309, United States

  • Policlinico Gemelli Universita Cattolica

    Roma, 00168, Italy

  • Rabindranath Tagore International Institute of Cardiac Sciences

    Kolkata, 700099, India

  • Radboud Umcn

    Nijmegen, 6525 GA, Netherlands

  • Ramathibodi Hospital Mahidol University

    Bangkok, 10400, Thailand

  • Renji Hospital

    Shanghai, 201112, China

  • Reno Heart Institute

    Reno, Nevada, 89511, United States

  • Renova Century Hospitals

    Hyderabad, 500034, India

  • Royal Free Hospital

    London, NW3 2QG, United Kingdom

  • Royal Hobart Hospital

    Hobart, 7000, Australia

  • Royal Prince Alfred Hospital

    Camperdown, 2050, Australia

  • Ruhr Universitat Bochum Diabeteszentrum

    Bad Oeynhausen, 32545, Germany

  • SBU Izmir Tepecik Egitim Ve Arastirma Hastanesi

    Izmir, 35020, Turkey (Türkiye)

  • SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine

    Kyiv, 02000, Ukraine

  • SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im Prof Leszka Gieca

    Katowice, 40 635, Poland

  • SRM Medical College Hospital & Research Centre

    Chengalpetu, 603203, India

  • Sahlgrenska Universitetsjukhuset

    Gothenburg, 413 45, Sweden

  • Saint Louis University Academic Pavillion

    St Louis, Missouri, 63110, United States

  • Samara Regional Clinical Cardiological Dispensary

    Samara, 443070, Russia

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • San Antonio Methodist TX Transplant Physicians Group

    San Antonio, Texas, 78229-3771, United States

  • Sanatorio Guemes

    C.a.b.a., C1180AAX, Argentina

  • Sanatorio Ramon Cereijo

    Caba, C1048AAN, Argentina

  • Sanatorio de la Trinidad Mitre

    Buenos Aires, C1039AAO, Argentina

  • Sapporo Medical University Hospital

    Sapporo, 060 8543, Japan

  • Sarawak Heart Center

    Kota Samarahan, 94300, Malaysia

  • Scientific and Research Institution of Cardiovascular Diseases Complex Problems

    Kemerovo, 650002, Russia

  • Scripps Memorial Hospital

    La Jolla, California, 92037, United States

  • Semmelweis Egyetem,Pulmonológiai Klinika

    Budapest, 1083, Hungary

  • Seoul National University Hospital

    Seoul, 3080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center

    Jerusalem, 91031, Israel

  • Shanghai Pulmonary Hospital

    Shanghai, 200433, China

  • Sheffield Teaching Hospitals NHS Foundation Trust Royal Hallamshire Hospital

    Sheffield, S10 2RX, United Kingdom

  • Shengjing Hospital Of China Medical University

    Shenyang, 110004, China

  • Shinshu University Hospital

    Matsumoto, 390 8621, Japan

  • Sir Ganga Ram Hospital

    New Delhi, 110060, India

  • Siriraj Hospital Mahidol University

    Bangkok, 10700, Thailand

  • Siyami Ersek Training and Research Hospital

    Istanbul, 34668, Turkey (Türkiye)

  • Skanes universitetssjukhus

    Lund, 221 85, Sweden

  • Sociedade Hospitalar Angelina Caron - Hospital Angelina Caron

    Campina Grande do Sul, 83430-000, Brazil

  • Songklanagarind hospital

    Songkhla, 90110, Thailand

  • Srinagarind Hospital, Khon Kaen University

    Khon Kaen, 40002, Thailand

  • St Marianna University Hospital

    Kanagawa, 216 8511, Japan

  • St Vincent's hospital

    Darlinghurst, 2010, Australia

  • St. Antonius Ziekenhuis Nieuwegein

    Nieuwegein, 3435 CM, Netherlands

  • St. Joseph's Health Centre

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Vincent Medical Group, Inc.

    Indianapolis, Indiana, 46260, United States

  • State Autonomous HealthCare Institution 'Interregional Clinical Diagnostic Center'

    Kazan', 420101, Russia

  • State Autonomous Healthcare Institution of Tyumen Region 'Scientific and Practical Medical Center'

    Tyumen, 625032, Russia

  • State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams Ukraine

    Kyiv, 03680, Ukraine

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet és rendelő

    Szeged, 6720, Hungary

  • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii

    Bydgoszcz, 85-168, Poland

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • Tam Anh Hospital

    Ho Chi Minh City, 700000, Vietnam

  • Tam Duc Heart Hospital

    Ho Chi Minh City, 700000, Vietnam

  • The Chaim Sheba Medical Center

    Tel Litwinsky, 5265601, Israel

  • The Eastern Slovakia Institute of Cardiovascular Diseases

    Košice, 040 11, Slovakia

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, 400016, China

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 510120, China

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi'an, 710061, China

  • The General Hospital of Northern Theater Command

    Shenyang, 110000, China

  • The Oregon Clinic

    Portland, Oregon, 97220-9442, United States

  • The Oregon Clinic Pulmonary West

    Beaverton, Oregon, 97008, United States

  • The Prince Charles Hospital

    Chermside, 4032, Australia

  • The Republican Scientific-Practical Center ''Cardiology''

    Minsk, 220036, Belarus

  • The Robert Larner, M.D. College of Medicine at The University of Vermont

    Burlington, Vermont, 05405, United States

  • The Second Xiangya Hospital of Central South Hospital

    Changsha, 410011, China

  • The University of Tokyo Hospital

    Bunkyō City, 113-8655, Japan

  • Tianjin Medical University General Hospital

    Tianjin, 300052, China

  • Troy Beaumont

    Troy, Michigan, 53215, United States

  • ULB Hôpital Erasme

    Brussels, 1070, Belgium

  • USC Keck

    Los Angeles, California, 90033, United States

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • Uls Coimbra - Hosp. Univ. Coimbra

    Coimbra, 3004 561, Portugal

  • Uls Santa Maria - Hosp. Pulido Valente

    Lisbon, 1769-001, Portugal

  • Uls Sao Jose - Hosp. Santa Marta

    Lisbon, 1169-024, Portugal

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

    Porto Alegre, 90610-000, Brazil

  • Unidad de Investigacion Clinica en Medicina S.C. (UDICEM)

    Monterrey, 64718, Mexico

  • Universidade Federal De Minas Gerais - Hospital das Clínicas

    Belo Horizonte, 30130-100, Brazil

  • Universitaetsklinikum Regensburg

    Regensburg, 93053, Germany

  • University Clinical Center of Serbia

    Belgrade, 11000, Serbia

  • University Health Network - Toronto General Hospital

    Toronto, Ontario, M5G2C4, Canada

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospital Of Larissa

    Larissa, 41334, Greece

  • University Hospital of Alexandroupolis

    Alexandroupoli, 681 00, Greece

  • University Medical Center Ho Chi Minh city

    Ho Chi Minh City, 700000, Vietnam

  • University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD

    Sofia, 1750, Bulgaria

  • University Of Iowa - Hospitals & Clinics

    Iowa City, Iowa, 52242, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109-5000, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198-2265, United States

  • University of Ottawa Heart Institute

    Ottawa, Ontario, K1Y 4W7, Canada

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104-5545, United States

  • University of Tsukuba Hospital

    Tsukuba, 305 8576, Japan

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53792, United States

  • Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie

    Szczecin, 70 111, Poland

  • Uniwersytecki Szpital Kliniczny w Bialymstoku

    Bialystok, 15 276, Poland

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80214, Poland

  • VUMC Amsterdam

    Amsterdam, 1081 HV, Netherlands

  • Volgograd Regional Clinical Cardiology Center

    Volgograd, 400008, Russia

  • Washington University School Of Medicine

    St Louis, Missouri, 63110-1032, United States

  • West China Hospital Sichuan University

    Chengdu, 610041, China

  • Westmead Hospital

    Westmead, 2145, Australia

  • Winthrop University Hospital

    Mineola, New York, 11501, United States

  • Wojewodzki Szpital Specjalistyczny we Wroclawiu Osrodek Badawczo Rozwojowy

    Wroclaw, 51 124, Poland

  • Yitzhak Shamir Medical Center

    Ẕerifin, 70300, Israel

  • Zhongshan Hospital Fudan University

    Shanghai, China

  • Århus Universitetshospital, Skejby, Hjertemedicinsk Afdeling B

    Aarhus, 8200, Denmark

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