PULMONARY ARTERIAL HYPERTENSION

This study tested a medication called macitentan in children with pulmonary arterial hypertension (PAH), a serious condition causing high blood pressure in the lungs. It compared the drug to standard care to see if it was safe, worked well in children's bodies, and could help con…

This study tested two different ways to dose a medication called sotatercept for people with pulmonary arterial hypertension (PAH), a serious condition where blood vessels in the lungs narrow. Researchers compared giving the drug based on exact body weight versus using broader we…

This study tested whether an inhaled powder called treprostinil palmitil could help people with pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs. Over 100 adults with PAH who were already on stable medication were randomly assigned t…

This study tested an experimental oral medication called ACT-293987 for adults with pulmonary arterial hypertension (PAH), a serious lung and heart condition. Participants received either the drug or a placebo twice daily for 21 weeks to see if it improved blood flow in their lun…

This study tested whether adding a new drug called Sotatercept to existing treatments could help Japanese adults with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the lungs and heart. The 46 participants received Sotatercept injecti…

This study tested an inhaled drug called treprostinil in people with high blood pressure in their lungs caused by scarring lung disease. Researchers wanted to understand how the drug helps during exercise and affects quality of life after three months of use. The study involved 2…

This study tested whether a hormone called DHEA could improve heart function in people with pulmonary arterial hypertension (PAH), a serious condition causing high blood pressure in the lungs. Twenty-six participants took either DHEA or a placebo for 18 weeks, then switched, whil…

This Phase 3 study tested whether an inhaled drug called seralutinib could help adults with pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs and heart. The main goal was to see if the drug improved patients' ability to walk and delay…

This study tested whether a common heart medication, nitroglycerin, could be safely given as a mist to breathe in to relax tightened blood vessels in the lungs of people with pulmonary arterial hypertension. It involved 20 adult patients with this serious condition. The goal was …

This large, completed Phase 3 trial tested whether a new oral medication called selexipag could safely delay serious health events or death in adults with pulmonary arterial hypertension (PAH), a severe lung blood vessel disease. The study involved over 1,150 patients and compare…

This study tested a drug called macitentan in Japanese children with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the lungs and heart. The main goal was to see if taking the drug for 24 weeks improved how well the heart and lungs wo…

This study tested whether using portable oxygen during exercise helps people with serious lung blood vessel diseases walk farther. Forty Swiss patients with pulmonary hypertension walked for six minutes with and without oxygen to compare results. Researchers wanted to see if usin…

This study tested whether adding a new drug called ralinepag to standard treatments could help people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It involved 687 adults with PAH who were already on stable medication. The main goal was to see if…

This study tested whether adding the drug sotatercept to standard treatments could help people with severe pulmonary arterial hypertension (PAH), a life-threatening lung disease. It involved 173 participants with advanced PAH who were at high risk of death. Researchers compared s…

This study tested whether dapagliflozin, a medication typically used for diabetes, could help people with pulmonary arterial hypertension. Fifty-two patients with stable symptoms took either the drug or a placebo for several months while researchers measured their exercise capaci…

This study tested whether a procedure called pulmonary artery denervation (PADN), which disrupts nerves around the lung artery, could help people with pulmonary arterial hypertension (PAH). 128 adults with PAH were randomly assigned to receive either the real PADN procedure plus …

This study tested whether adding KER-012 injections to standard medications helps adults with pulmonary arterial hypertension, a serious condition where blood pressure is high in the lungs. 113 participants received either KER-012 or a placebo shot every 4 weeks for 24 weeks whil…

This study tested whether training the breathing muscles could help people with pulmonary hypertension feel less short of breath and be more active. For 8 weeks, 32 participants with the condition either did special breathing exercises or a sham version without resistance. Resear…

This study tested a single inhaled dose of an experimental drug called RT234 in people with pulmonary arterial hypertension (PAH). The main goal was to see if the drug could safely improve how well participants could exercise and reduce their feeling of breathlessness during phys…

This small, early-stage study looked at whether carnitine, a nutrient found in food, could help the heart in people with pulmonary arterial hypertension (PAH). Researchers first checked what participants ate and their blood carnitine levels. Then, they gave some participants carn…

This study tested how two drugs for pulmonary arterial hypertension (PAH) interact when taken together. Researchers gave healthy volunteers single doses of the experimental drug BIA 5-1058 and the established drug furosemide to see how one affects the other's levels in the body. …

This study looked at whether long-term exposure to air pollution makes pregnancy more dangerous for women who have pulmonary hypertension, a serious condition affecting blood pressure in the lungs. Researchers analyzed medical records from 1,200 pregnant women with this condition…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…