PULMONARY ARTERIAL HYPERTENSION

This study tested a drug called sotatercept (MK-7962) added to standard treatment for Japanese adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. 46 participants received the drug to see if it improve…

This study tested whether the hormone DHEA can improve heart function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure strains the heart. Twenty-six adults took DHEA or a placebo in two 18-week periods, with a washout in between. The mai…

This study tested a procedure called pulmonary artery denervation (PADN) for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. 128 adults received either the real procedure or a sham (fake) operation. The main goal was to s…

This study tested an inhaled medication called treprostinil palmitil in 102 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. The goal was to see if the drug could lower resistance in lung bloo…

This study tested an experimental drug called ACT-293987 in 43 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. The trial first checked how a single dose affects blood flow in the lungs, then compared the drug to a placebo…

This study tested an inhaled medication called seralutinib in 390 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe and exercise. The goal was to see if the drug helps people walk farther in six minutes and delays the diseas…

This study tested an investigational drug called KER-012 in 113 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants took KER-012 or a placebo alongside their usual PAH medications. The goal was to see if KER-012 …

This study looked at how the drug CS1 changes small blood vessels in the lungs of people with pulmonary arterial hypertension (PAH). Seven participants received CS1 and had special lung scans at the start and after 12 months. The goal was to see if CS1 could improve blood vessel …

This study tested the drug dapagliflozin, usually used for diabetes, in 52 adults with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension. The goal was to see if it could improve exercise capacity and heart function. Participants took the drug …

This study tested whether the drug sotatercept, given for 36 weeks, can improve how the heart and lungs work during exercise in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH took part. The main goal was to see if the drug helps the heart pump blood mor…

This study tested an inhaled medication called RT234 in 14 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. The goal was to see if the drug could lower lung blood pressure and check for side effects li…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it safely reduces stress on the right side of the heart and improves heart function. Participants took either spironolactone or a placebo, and researchers measure…

This study looked at how an inhaled medication called treprostinil affects exercise ability in people with pulmonary hypertension caused by interstitial lung disease. 29 participants took the drug for 3 months. Researchers measured heart function and breathing efficiency during e…

This study tested a drug called macitentan in 7 Japanese children (ages 3 months to 15 years) with pulmonary arterial hypertension, a condition where blood pressure in the lungs is dangerously high. The goal was to see if the drug improves blood flow through the lungs after 24 we…

This study tested an experimental pill called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. About 687 adults with PAH took either ralinepag or a placebo on top of their usual treatments. The goal was …

This study tested a drug called macitentan in 165 children with pulmonary arterial hypertension (PAH), a serious condition where blood pressure in the lungs is too high. The goal was to see how the drug works in the body, if it is safe, and if it helps control the disease better …

This study tested a drug called selexipag in over 1,100 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. The goal was to see if selexipag could delay the first time a patient's condition got worse or led to death, compared…

This study looked at two ways of giving the drug sotatercept to 164 adults with pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow, making it hard to breathe. Researchers compared a standard weight-based dose to a simpler weight-banded approach to …

This study tested a drug called sotatercept in 173 people with severe pulmonary arterial hypertension (PAH) who were at high risk of dying. Participants received either the drug or a placebo on top of their usual treatments. The goal was to see if the drug could delay death, the …

This study tested whether 8 weeks of inspiratory muscle training (exercises to strengthen breathing muscles) could help people with pulmonary hypertension. 32 adults with the condition participated. The goal was to see if the training improved exercise capacity and breathing resp…

This study looked at whether people with pulmonary vascular disease (problems with blood vessels in the lungs) need extra oxygen during exercise to walk as far. 40 adults with this condition walked on both room air and low-flow oxygen to compare distances. The goal was to see if …

This study looked at whether a single dose of an inhaled drug called RT234 can safely help people with pulmonary arterial hypertension (PAH) exercise longer and feel less short of breath. 42 adults with PAH took the drug and then did exercise tests. The main goals were to check s…

This study looked at 112 people with pulmonary hypertension (high blood pressure in the lungs) to see if heart MRI scans could better predict who needs a transplant or may die. Researchers compared MRI results with standard heart catheterization tests. The goal was to improve how…

This study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH completed the study, which measured carnitine in their diet and blood over several weeks. The goal was to g…

This study tested a special MRI technique using inhaled xenon gas to see how well the lungs exchange gas in people with pulmonary arterial hypertension (PAH). Ten adults with PAH had four MRI scans over 18 weeks while starting or continuing treatment. The goal was to find new ima…

This study looked at whether breathing in nitroglycerin (a medicine that opens blood vessels) is safe and effective for people with pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow. Twenty adults with PAH took part. The goal was to see if the spr…

This study looked at 1,200 pregnant women with pulmonary hypertension (high blood pressure in the lungs) to see if long-term exposure to air pollution raised their risk of serious problems like heart failure or death. Researchers reviewed medical records from 2013 to 2022. The go…

This study looked at how two medicines, BIA 5-1058 and furosemide, affect each other in the body. It involved 44 healthy adults who took the drugs alone and together. The goal was to gather safety and drug-level information to help design future treatments for pulmonary arterial …

This study looked at whether a special MRI scan (4D Flow) can measure blood flow in the lungs as accurately as the standard invasive test (cardiac catheterization) in people with pulmonary hypertension linked to congenital heart disease. Researchers enrolled 50 patients aged 7 an…

This study looked at 629 adults with different types of pulmonary arterial hypertension (PAH), including those linked to HIV, heart defects, and connective tissue diseases. Researchers tested blood for antibodies that attack blood vessel and lung cells to see if these immune mark…