Oxygen on the go: do patients really need it during exercise?
NCT ID NCT06384534
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether people with pulmonary vascular disease (problems with blood vessels in the lungs) can walk the same distance in 6 minutes without extra oxygen as they can with it. 40 adults who had low oxygen levels during exercise did two walk tests—one breathing normal air and one breathing extra oxygen through a nasal tube. The goal was to see if skipping oxygen makes a meaningful difference in how far they can walk.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- supplemental oxygen therapy (nasal low oxygen)
- What this could lead to
- If it works, this could show that some patients don't need portable oxygen during exercise, simplifying daily life.
- What could go wrong
- This is a small, completed study with only 40 participants, so results may not apply to everyone. It only looked at short-term walking distance, not long-term benefits or risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Started
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Apr 2024
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Minimum 18 years of age * Written informed consent * Patients with diagnosed pulmonary arterial hypertension (PAH), distal chronic thromboembolic pulmonary hypertension (CTEPH) * Former desaturation under exercise defined as Spo2-decrease \>3% * Treated with a stable drug therapy (with no changes for at least 14 days prior to screening) Exclusion Criteria: * Severe hypoxemia needing supplemental oxygen therapy defined as partial pressure of O2 (PaO2) \< 6.9 Kilopascal (kPa) * Pregnancy * Unability or contraindications to undergo the investigated intervention * Unability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Hospital Zürich
Zurich, Canton of Zurich, 8091, Switzerland
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