University Of Zurich

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This phase II trial is testing a type of radiation called online adaptive stereotactic body radiotherapy (SBRT) for men with localized prostate cancer who also have lower urinary tract symptoms or an enlarged prostate. The treatment uses CT or MRI scans to adjust the radiation be…

This study tests whether giving less radiation to healthy lymph nodes can reduce side effects for people with oropharynx cancer. The approach uses a computer model to personalize which lymph nodes need treatment. The trial will enroll 120 patients and track if cancer returns in u…

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region that controls movement can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS device and be followed for 6 months. The goal is to see if the treatme…

This study tests whether using a robotic arm during a lung biopsy helps doctors get better tissue samples to diagnose interstitial lung disease. About 30 adults with unclear CT scans will be randomly assigned to either standard or robotic-assisted bronchoscopy. The goal is to see…

This study tests whether an oral blood pressure drug, propranolol, can prevent severe eye disease (retinopathy of prematurity) in extremely premature infants. About 276 babies born before 28 weeks and weighing under 1250 grams will receive either propranolol or a placebo. The goa…

This study is testing a smartphone app that prompts people with depression to ask for help from friends or family at the right moments. Over 21 days, 120 adults waiting for therapy will be randomly assigned to different versions of the app or no app at all. The goal is to see if …

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study tests whether Eye Movement Desensitization and Reprocessing (EMDR) therapy can help people with PTSD caused by a heart attack. Sixty adults who had a heart attack and developed PTSD will receive eight weekly EMDR sessions. The goal is to see if EMDR reduces PTSD sympto…

This study tests whether playing soft sounds during deep sleep can improve the effects of a home-based brain training program for people with Parkinson's disease and mild memory problems. Fifty participants will use a sleep device at night and complete cognitive exercises for fiv…

This study tests whether natural cervical ripening methods can help labor start on its own in pregnant women with diet-controlled gestational diabetes. About 74 participants will try these methods starting at 37 weeks to see if they can avoid a medically induced labor. The goal i…

This study tests whether injecting a cat allergy treatment directly into lymph nodes is safe and well-tolerated in 36 adults with cat allergy and asthma. Participants receive 3-4 ultrasound-guided injections and are monitored for allergic reactions and immune changes. The goal is…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This study tests a new counseling program designed to help people with COPD cope with emotional distress during a sudden worsening of their condition. Twenty adults hospitalized for a COPD flare-up will receive ten counseling sessions with a specialized nurse over three months. T…

This long-term study follows 1,000 people with eczema and related allergies, plus healthy volunteers, to see what factors help the disease go into remission. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better unders…

This study tracks 420 people to see how bariatric surgery affects drinking behavior using a special device called a drinkometer. It measures things like sip size and speed, and looks at how gut hormones and sex differences play a role. The goal is to better understand why surgery…

This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain. No treatment or medication is tested—only ob…

This study looks at why some people develop long-term nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks to understand the underlying mechanisms. The goal is to better classify pain types, which may eventually lead to…

This study uses a special imaging technique called electrical impedance tomography (EIT) to watch how lung volumes change in preterm babies on synchronized noninvasive ventilation (sNIPPV). Researchers want to understand why sNIPPV works better than other breathing support method…

This study uses MRI scans to observe how the brain and spinal cord change after a spinal cord injury. Researchers will compare 450 patients (from recent to long-term injury) with healthy volunteers. The goal is to find imaging markers that can predict recovery and guide rehabilit…

This study looks at why about half of stroke patients who have a successful procedure to reopen a blocked brain artery still don't fully recover. Researchers will use a special MRI technique to measure blood flow changes in the brain at 3 days, 7 days, and 90 days after the proce…

This study tests whether applying heat pads or using a massage gun can reduce stiffness in the jaw muscle (masseter). Researchers will measure muscle stiffness with a special ultrasound in 40 healthy adults. The goal is to gather data that could lead to better treatments for jaw …

This study aims to learn how the brain and spinal cord change after a stroke. Researchers will use MRI scans to compare stroke patients with healthy volunteers. The goal is to find patterns that predict recovery and understand why symptoms vary. The study does not test a treatmen…

This pilot study tests whether a robot-assisted bronchoscopy (a lung biopsy using a thin, flexible tube) can be done safely and effectively under moderate sedation with propofol, instead of the deeper anesthesia usually required. About 30 adults scheduled for a lung biopsy will t…

This study collects and analyzes exhaled breath from 5,000 adults with lung or airway diseases. The goal is to find unique breath patterns that can help identify different respiratory conditions and track how they change over time. Participants provide breath samples and symptom …

This study is gathering information on how people naturally recover from spinal cord injuries. Researchers will follow 8000 participants across Europe, measuring their independence, movement, and nerve function over time. The goal is to create a detailed baseline of recovery, whi…

This study aims to identify unique patterns in exhaled breath that can indicate recent medication intake or the presence of lung diseases like sleep apnea. Researchers will collect breath samples from 1500 adults and analyze them using a special mass spectrometry technique. The g…

This study looks at whether a quick, practical health assessment can help predict serious side effects in people aged 65 and older who are about to receive CAR-T cell or bispecific antibody therapy for certain blood cancers. Researchers will test participants' mobility, memory, s…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study aims to better understand primary immune deficiencies (PID), a group of diseases where the immune system doesn't work properly. Researchers will collect blood, stool, urine, and tissue samples from 300 people with PID and healthy volunteers to analyze immune responses.…

This study looks at a little-known part of the brain called the reticulospinal system, which helps control movement like posture and walking. Researchers will use loud sounds and motion tracking to test how this system works in healthy people and those with spinal cord injury. Th…

This study observes 250 stroke patients to compare how well doctors and a computer model predict recovery after a stroke. Researchers will track disability and stroke severity at 24 hours and 3 months. The goal is to improve prediction tools for better patient care.

This study uses advanced MRI scans to look at changes in the spinal cord and fluid around it in people with spinal cord injuries. The goal is to see if these changes relate to a person's symptoms and nerve function. Researchers hope this will lead to earlier diagnosis and better …

This study looks at how tiny organisms (microbiome) and the immune system work together in the bladder. Researchers will collect samples from 800 adults with different urinary problems, like infections or bladder pain, and compare them to healthy volunteers. The goal is to unders…

This study looks at how the brain changes in people born without a hand or upper limb. Researchers will use brain scans and simple tasks to compare their brain activity and structure to those with both arms. The goal is to understand how early life shapes the brain's ability to a…

This study aims to create a test that combines blood tests, scans, and immune system checks to predict which lymphoma patients will benefit from CAR T cell therapy. About 50 adults with relapsed or hard-to-treat B-cell lymphoma will be followed for three months after treatment. T…

This study is testing a new approach called pharmacoscopy, which quickly tests many drugs on a patient's own tumor cells in the lab. The goal is to see if this personalized method helps doctors choose better treatments for people with brain metastases who have run out of standard…