University Of Zurich

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This study tests whether natural cervical ripening methods can help pregnant women with diet-controlled gestational diabetes go into labor on their own, avoiding a medically induced labor. About 74 women will try these methods starting at 37 weeks. The goal is to see if natural a…

This study is for people with oropharynx cancer who need radiation therapy. Researchers want to see if giving radiation to fewer lymph nodes, based on each person's cancer spread, can lower side effects without causing cancer to return in untreated areas. About 120 participants w…

This study tests a new type of radiation therapy that adapts to the patient's anatomy each week, aiming to treat prostate cancer while reducing side effects in men who also have urinary problems or an enlarged prostate. About 75 participants will receive five weekly sessions of t…

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region that controls movement can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS device and be followed for 6 months. The goal is to see if the treatme…

This study tests whether using a robotic arm during a lung biopsy helps doctors get better tissue samples to diagnose interstitial lung disease. About 30 adults with unclear CT scans will be randomly assigned to either standard or robotic-assisted bronchoscopy. The goal is to see…

This study tests a daily 30-minute nerve stimulation treatment (TTNS) to prevent bladder overactivity in people with a recent spinal cord injury. About 114 participants will receive either real or sham stimulation for 6-9 weeks. The goal is to see if this approach can protect the…

This study tests whether an oral blood pressure drug, propranolol, can prevent severe eye disease (retinopathy of prematurity) in extremely premature infants. About 276 babies born before 28 weeks and weighing under 1250 grams will receive either propranolol or a placebo. The goa…

This study tests a smartphone app that sends timely prompts to help adults with depression connect with others for emotional or practical support. Over 21 days, 120 participants will be tracked six times daily to see if these prompts reduce depressive symptoms and loneliness. The…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This study tests whether adding booster sessions and homework reminders to a brief psychological program (Problem Management Plus) helps reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will take part. T…

This study tests a new counseling program designed to help people with COPD cope with emotional distress during a sudden worsening of their condition. Twenty adults hospitalized for a COPD flare-up will receive ten counseling sessions with a specialized nurse over three months. T…

This study is testing whether a type of therapy called EMDR can reduce PTSD symptoms in people who had a heart attack. About 60 adults with heart-related PTSD will receive EMDR or standard care, and researchers will check their stress levels and heart health over 6 months. The go…

This study tests a new 3-month counseling program for people with stable COPD. The program is led by a nurse and focuses on emotional distress caused by the disease. It includes 10 sessions and aims to see if the program is practical and helpful. Only 15 participants will take pa…

This study tests whether improving deep sleep with soft sounds can make cognitive training more effective for people with Parkinson's disease and mild cognitive impairment. Fifty participants will do a 5-week brain fitness program at home while using a sleep device that plays sou…

This study tests a new type of allergy shot for people with cat allergy and asthma. The shot is given directly into a lymph node to try to reduce allergic reactions. 36 adults aged 18-65 will receive 3-4 injections and be monitored for safety and immune changes. The goal is to se…

This study aims to identify unique patterns in exhaled breath that can indicate recent medication intake or the presence of lung diseases like sleep apnea. Researchers will collect breath samples from 1500 adults and analyze them using a special mass spectrometry technique. The g…

This study looks at whether a quick, practical health assessment can help predict serious side effects in people aged 65 and older who are about to receive CAR-T cell or bispecific antibody therapy for certain blood cancers. Researchers will test participants' mobility, memory, s…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study aims to better understand primary immune deficiencies (PID), a group of diseases where the immune system doesn't work properly. Researchers will collect blood, stool, urine, and tissue samples from 300 people with PID and healthy volunteers to analyze immune responses.…

This study follows 1,000 people with eczema and related allergies to learn why some get better and others don't. Researchers will collect health data and samples to find clues that could lead to new treatments. The goal is to understand the disease better, not to test a new drug.

This study looks at a little-known part of the brain called the reticulospinal system, which helps control movement like posture and walking. Researchers will use loud sounds and motion tracking to test how this system works in healthy people and those with spinal cord injury. Th…

This study looks at how the lungs of premature babies change volume when they receive synchronized noninvasive breathing support (sNIPPV). Researchers will use a special imaging technique (EIT) to compare different types of breaths and ventilator inflations. The goal is to unders…

This study collects and analyzes exhaled breath from 5,000 adults with lung or airway diseases. Researchers aim to find unique breath patterns that can help identify different respiratory conditions and track disease changes over time. Participants must be 18 or older and able to…

This study aims to understand how people naturally recover after a spinal cord injury. Researchers will follow 8,000 participants across Europe, measuring their independence, neurological function, and walking ability over time. The goal is to create a detailed baseline of natura…

This study observes 250 stroke patients to compare how well doctors and a computer model predict recovery after a stroke. Researchers will track disability and stroke severity at 24 hours and 3 months. The goal is to improve prediction tools for better patient care.

This study uses advanced MRI scans to look at changes in the spinal cord and fluid around it in people with spinal cord injuries. The goal is to see if these changes relate to a person's symptoms and nerve function. Researchers hope this will lead to earlier diagnosis and better …

This study looks at how tiny organisms (microbiome) and the immune system work together in the bladder. Researchers will collect samples from 800 adults with different urinary problems, like infections or bladder pain, and compare them to healthy volunteers. The goal is to unders…

This study uses MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will compare 450 people with spinal cord injuries to healthy volunteers. The goal is to better understand recovery and find markers that predict how a person will improve…

This study looks at how the brain changes in people born without a hand or upper limb. Researchers will use brain scans and simple tasks to compare their brain activity and structure to those with both arms. The goal is to understand how early life shapes the brain's ability to a…

This pilot study with 30 adults checks if a robot-assisted bronchoscope can safely and accurately biopsy lung lesions when patients are given moderate sedation with propofol, instead of deep anesthesia. The goal is to see if the robot can confirm the biopsy tool reaches the targe…

This study tests whether applying heat pads or using a massage gun can reduce stiffness in the jaw muscle. Researchers will measure muscle tightness with a special ultrasound in 40 healthy adults. The goal is to find better ways to treat jaw pain and disorders like TMD.

This study looks at why about half of stroke patients don't fully recover even after doctors successfully remove a blood clot from their brain. Researchers will use a special MRI technique to measure blood flow changes in the brain at 3 days, 7 days, and 90 days after the procedu…

This study aims to understand why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve recordings, and body responses like heart rate and pupil size to measure how pain signals work. The study includes 300 adults with spinal cord injur…

This study aims to learn how the brain and spinal cord change after a stroke. Researchers will use MRI scans to compare stroke patients with healthy volunteers. The goal is to find markers that can predict recovery and understand what affects a patient's symptoms.

This study aims to create a test that combines blood tests, scans, and immune system checks to predict which lymphoma patients will benefit from CAR T cell therapy. About 50 adults with relapsed or hard-to-treat B-cell lymphoma will be followed for three months after treatment. T…

This study uses a special device called a drinkometer to precisely measure how people drink and eat after bariatric surgery, instead of relying on self-reports. Researchers will study 420 adults with obesity to see how sex and gut hormones affect eating behaviors. The goal is to …

This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow syndrome, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain and why they often occur together. R…

This study is testing a new approach called pharmacoscopy, which quickly tests many drugs on a patient's own tumor cells in the lab. The goal is to see if this personalized method helps doctors choose better treatments for people with brain metastases who have run out of standard…