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Brain secrets revealed: study probes how missing limbs reshape the mind

NCT ID NCT06043518

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the brain changes in people born without a hand or upper limb. Researchers will use brain scans and simple tasks to compare their brain activity and structure to those with both arms. The goal is to understand how early life shapes the brain's ability to adapt, which may help improve care for people with limb differences.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with an upper-limb amputation and healthy subjects.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria - Patients: * Age 18-75 * Upper-limb congenital amputees with complete absence of a hand * Signed informed consent Exclusion Criteria - Patients: * Contraindications to magnetic resonance imaging * Neurological impairment of body function impairments not induced by spinal cord injury * BMI \> 40 * Pregnancy * Claustrophobia Inclusion Criteria - Healthy subjects: * Age 18-75 * Signed Informed consent Exclusion Criteria - Healthy subjects: * Contraindications to magnetic resonance imaging * Pregnancy * Neurological illness * Impairment of body function induced by a congenital upper-limb amputation * Claustrophobia * BMI \> 40

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Conditions

The condition(s) this trial relates to.

amelia of upper limb amniotic band syndrome Amputation, Congenital Ectromelia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation, congenital Upper limb; amelia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Balgrist Campus

    RECRUITING

    Zurich, Canton of Zurich, 8008, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.