Scientists use super MRI to peek inside brains of migraine and epilepsy patients
NCT ID NCT05524493
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain. No treatment or medication is tested—only observation and questionnaires.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The participants will be recruited from the primary care clinics as well as from referring physicians or other clinics. Healthy controls will be recruited via public announcements and via flyers distributed at a primary care clinic and two universities.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients: * Patient must be able to read and sign the informed consent form * Stable prophylactic medication for 2 months prior to MRI * At leat one of the two criteria applies: * Patients diagnosed with migraine (with or without aura, episodic or chronic). Diagnosis is ensured by clinical interview (at least 8 weeks prior to MRI). Also, patients complete a migraine questionnaire (HARDSHIP) (at least 8 weeks before MRI). Migraine frequency ≥ 2 migraine attacks/month. * Patients with drug resistent epilepsy accroding to ILAE crtieria * Patients with diagnoses of Visual snow syndrome Healthy participants; * No migraine (validated by questionnaire) or epilepsy * Participants must be able to read and sign the informed consent form Exclusion Criteria: * Treatment of migraine disease with Botox within \< 4 months before baseline and during the study period * Pregnant or breastfeeding women * Intention during the course of the trial to become pregnant * Women with bilateral ovariectomy, with or without hysterectomy, and postmenopausal women (\>2 years of age) are not considered childbearing. * Other clinically significant comorbidities (e.g., renal insufficiency, hepatic dysfunction, cardiovascular disease, etc.), * Known or suspected noncompliance with the protocol, drug or alcohol abuse, * Patient's inability to follow trial procedures, e.g., due to language problems, mental illness, dementia, etc., * Prior participation in the clinical trial * Enrolment of the investigator, his/ her family members, employees and other dependent persons of the test personnel * Metallic objects in the body (e.g., splinters, MR incompatible implants). * Pacemaker * Claustrophobia * Obesity (body mass index \> 35 kg/m2)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Klinik Lengg
RECRUITINGZurich, 8008, Switzerland
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University Hospital Zurich
RECRUITINGZurich, 8091, Switzerland
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