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Scientists probe why spinal injury leads to debilitating nerve pain

NCT ID NCT06443281

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks in 300 participants to understand the underlying causes. The goal is to better classify pain types, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal how neuropathic pain arises after spinal cord injury, pointing toward better ways to diagnose or manage it in the future.
What could go wrong
This is an observational study, not a treatment trial. It aims to understand pain, not cure or relieve it. Results may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

In- and outpatients of Balgrist University Hospital Zurich

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Spinal injury cohort - general inclusion criteria: * Aged between 18-80 years * Traumatic and non-traumatic etiology * Para- and tetraplegic SCI * Complete and incomplete SCI * SCI with and without neuropathic pain * Additional inclusion criteria for longitudinal study: * SCI since less than one month * Additional inclusion criteria for cross-sectional study: * SCI since more than one year * Control cohorts with peripheral neuropathy: * General inclusion criteria: * Aged between 18-80 years * Neurological disorder affecting the peripheral nervous system (i.e., peripheral neuropathy) * Peripheral neuropathy with or without neuropathic pain * Additional inclusion criteria for longitudinal study: * Peripheral neuropathy since less than one month * Additional inclusion criteria for cross-sectional study: * Peripheral neuropathy since more than one year * Control cohorts without neuropathy / healthy volunteers * General inclusion criteria: * Aged between 18-80 years * No medical condition affecting the peripheral and/or central nervous system (e.g., pain, systemic disease, psychological disorder) Exclusion Criteria: * Inability to follow study instructions * Pregnancy * Medically manifested psychological disorder * Medical condition affecting the peripheral and/or central nervous system other than the desired experimental condition (e.g., additional peripheral neuropathy in the SCI cohort)

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Conditions

The condition(s) this trial relates to.

neuralgia Nociceptive Pain peripheral neuropathy spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neuropathy Nociceptive pain Pain, neuropathic Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Balgrist University Hospital

    RECRUITING

    Zurich, Canton of Zurich, 8008, Switzerland

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