HEALTHY VOLUNTEER

This study tested whether a simple, non-invasive ultrasound can accurately detect when a child's stomach contains too much fluid, which can be dangerous during anesthesia. Researchers gave 92 healthy children different amounts of clear liquid to drink, then used ultrasound to che…

This study tested whether a single injection of nirsevimab can prevent hospitalizations from RSV, a common winter virus that can cause serious breathing problems in infants. Over 8,000 healthy babies under 12 months old received either the shot or no intervention. The goal was to…

This study tested whether taking a daily tablet of a special probiotic (LC-Plasma) could prevent upper respiratory infections like colds in healthy adults. Over 600 people took either the probiotic or a placebo for 24 weeks. Researchers tracked how many people got sick and how se…

This study tested whether a daily probiotic tablet called LC-Plasma could help healthy adults fight off colds and other upper respiratory infections. 241 Australian adults took either the probiotic or a placebo for 4 weeks. Researchers measured immune cell activity and tracked an…

This study tested whether a daily oral supplement called CaroRite™, made from carotenoids, can improve skin health and reduce visible signs of aging like wrinkles and dryness. Eighty healthy women aged 40-55 took either the supplement or a placebo for a period of time. Researcher…

This early-stage study tested the safety and how the body handles ABBV-932, an oral drug, in 20 healthy Chinese adults. Participants took multiple doses to see how the drug moves through the body and if it causes side effects. The goal was to gather information, not to treat any …

This study tested a quicker, 6-lead ECG device placed on the chest against the standard 12-lead ECG in 24 healthy adults. The goal was to see if the simpler device gives accurate heart measurements, which could speed up heart checks in emergencies. Results will show how well the …

This phase 1 study looked at how the body absorbs icovamenib capsules when taken with or without food. Sixty healthy adults participated to help researchers understand the drug's behavior. The goal was to gather information, not to treat any disease.

This study tested a new drug called ABBV-142 in 73 healthy adults to see if it is safe and how the body handles it. Participants received a single dose, and researchers monitored side effects and drug levels in the blood. The goal was to gather early safety information, not to tr…

This early-stage study tested an experimental drug called SAGE-718 in 40 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity and safety. The goal was not to treat any disease, but to gather information for future research.

This study looked at whether a single pill containing three diabetes medicines (gemigliptin, dapagliflozin, and metformin) works the same as taking them separately. Fifty healthy adults took either the combo pill or the separate pills after a meal, and researchers measured drug l…

This early-stage study tested a new drug called REGN9533 in 72 healthy adults to see if it is safe and how the body handles it. The drug targets a clotting protein and may one day help prevent dangerous blood clots. No treatment was given—this trial only gathered safety and dosin…

This study looked at how two similar drugs, AVP-786 and AVP-923, are processed by the body. 62 healthy adults took both drugs at different times. The goal was to measure drug levels and check safety, not to treat any disease.

This study involved one healthy volunteer (the lead researcher) who gave himself an experimental oncolytic virus called OTS-412. The goal was not to treat any disease but to closely monitor how the immune system responds over time. Researchers took many blood samples to track cha…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children and adults with movement problems, and older adults with lung conditions. The goal was to s…

This study looked at how a high-fat meal changes the way ABBV-101 moves through the body. Seventeen healthy adults took the drug by mouth, and researchers measured its levels in the blood. The goal was to understand food's impact, not to treat any disease. Results help guide futu…

This study involved 263 healthy adults to see how well the drug risankizumab is absorbed when given through a wearable on-body injector compared to a standard injection. The goal was to measure drug levels in the blood and check for side effects. No treatment benefit was expected…

This study tested a new diclofenac gel (AMZ001) applied once daily on each knee and compared it to a standard diclofenac gel applied four times daily. The goal was to see how much of the drug enters the blood and to check safety. Thirty-four healthy adults took part over 7 days.

This study tested two different ways to give the same medicine (pegfilgrastim) to 180 healthy adults. One group got the medicine through a pre-filled syringe, the other through an autoinjector. The goal was to see if the body absorbs the drug the same way and to check for any saf…

This study looked at whether a tablet form of the drug omaveloxolone (used for Friedreich's Ataxia) that dissolves in liquid is processed by the body the same way as the current capsule form. 70 healthy adults each took both forms, with a 14-day break in between. The goal was to …

This study looked at how the COVID-19 pandemic and related changes, like social distancing, affected people's mental health. Over 3,600 English-speaking adults completed online surveys every two weeks for up to six months. The goal was to learn how pandemic-related stress influen…

This study looked at whether drinking calvados (a strong apple brandy) during a high-calorie festive meal helps with digestion, as some people believe. Eight healthy volunteers ate a large meal and either had water or calvados with sorbet in the middle. Researchers used ultrasoun…

This study looked at how a new tablet form of the drug venetoclax is absorbed by the body in 72 healthy female volunteers. Researchers compared the new tablet to the current commercial version and also checked if taking it with a high-fat meal changed absorption. The goal was to …

This study checked how a new drug called ESK-001 affects the heart's electrical activity in 52 healthy adults aged 18 to 55. Participants received ESK-001, a placebo (fake drug), and moxifloxacin (a known heart-effect drug) in a random order. The goal was to see if ESK-001 causes…

This study tested two versions of the drug ARN-75039 in 16 healthy adults to see how well each is absorbed after a meal. One version is a tablet with extra ingredients, the other is a plain capsule. Participants took both forms one week apart, and researchers measured drug levels…

This study used MRI scans to measure how the brain moves inside the skull during gentle head movements, like turning or nodding. Researchers studied 90 healthy adults aged 18 to 65 to create a detailed map of brain deformation. The goal was to develop a new imaging method that co…

This study collects blood, skin, or mouth tissue samples from healthy volunteers and people with skin diseases. The samples are used to support research on skin and other health conditions. About 304 people took part. No treatment or cure is being tested.

This study screened over 3,800 people with neurological conditions and healthy volunteers to collect information for future research. No treatments were given. The goal was to understand these conditions better and find suitable participants for other studies.

This early-stage study tested a new investigational drug, SAR444336, in 76 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo as a single dose or repeated doses. The goal was to gather safety information before test…

This study tested a drug called EP395 in 40 healthy adults to see how it affects temporary lung inflammation caused by an inhaled substance. The goal was to measure changes in blood and lung markers of inflammation and check the drug's safety. Participants were healthy volunteers…

This study looked at how a natural gut hormone called GLP-1 affects bone turnover in 12 healthy adults. Participants received either GLP-1 or a placebo for three days. The goal was to see if GLP-1 changes bone formation and breakdown markers. This is early-stage research to bette…

This study tested whether a virtual reality program (DeepDream) can produce experiences similar to those caused by psychedelic drugs. Ten healthy volunteers took part, and researchers measured their altered states of consciousness using standard questionnaires. The goal was to se…

This study looked at how a single dose of the experimental drug MT-8554 is absorbed, broken down, and removed from the body in 6 healthy men aged 30-55. Researchers measured the drug's levels in blood, urine, and stool over time. The goal was to understand the drug's behavior and…

This study tested whether MT-8554, an experimental drug, changes the heart's electrical activity (QT interval) in 48 healthy adults aged 18-55. Participants received either a low dose, high dose, or placebo. The goal was to see if the drug causes any heart rhythm issues, not to t…

This early-stage study tested a single dose of ARGX-109 in 40 healthy adults to see if it is safe and how the body processes it. Participants were monitored for about 20 weeks. The goal was to gather safety data, not to treat any disease.

This early-stage study tested multiple doses of MLS101, a low-dose psilocybin drug, in 20 healthy adults aged 18 to 55. Researchers used brain scans (fMRI) to see how the drug affects brain activity and checked for side effects and how the drug moves through the body. The goal wa…

This study tested a new antibody drug (BMS-986446) in 46 healthy adults to see how well it is absorbed when given as a shot under the skin compared to an IV. The main goal was to measure drug levels in the blood and check for side effects. This early-stage research helps understa…

This study tracked how a single dose of varegacestat moves through and leaves the body of 6 healthy adult men. Researchers measured the drug and its breakdown products in blood, urine, and stool. The goal was purely to understand the drug's absorption and elimination, not to trea…

This early-stage study tested the safety and tolerability of a new drug called ABBV-8736 in 24 healthy adult volunteers. Participants received multiple doses of the drug or a placebo to see how the body processes it and whether it causes side effects. The goal was not to treat an…

This early-stage study tested the safety and how the body processes a new drug called ABBV-CLS-616 in 110 healthy volunteers. Participants took single or multiple doses of the drug to check for side effects and how it interacts with food or other medicines. The goal was to gather…

This study looked at how a drug being tested for Alzheimer's disease (BIIB080) spreads through the brain and spinal cord. Five healthy adults received a tiny radioactive version of the drug along with a regular dose. Researchers used PET scans to track where the drug went and che…

This early-stage study tested a new drug, DD-S052P, in 64 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by IV, in single or multiple doses. The goal was to check for side effects and measure drug levels in th…

This early-stage study tested an experimental drug called SAGE-718 in 19 healthy adults to see how it affects brain chemicals when combined with ketamine. Participants received both the drug and a placebo at different times, and brain scans measured changes in key chemicals. The …

This early-stage study tested the safety and tolerability of a new drug called VNA-318 in 92 healthy men. Participants received either single or multiple doses of the drug or a placebo. The goal was to see how the body handles the drug and check for side effects, not to treat any…

This study looked at how a medical food containing a substance called tri-betahydroxybutyrin is absorbed and processed by the body. 18 healthy men aged 60 and older took the product and gave blood samples over 24 hours. The goal was to understand the levels of certain compounds i…

This study tested whether a new drug called BIIB800 works similarly to an approved drug, Actemra, in the body. It involved 300 healthy male volunteers who received a single injection. The goal was to measure how the drugs are absorbed and processed, not to treat any disease.

This study looked at how the drug omaveloxolone (used for Friedreich's Ataxia) affects the way the body processes omeprazole (a common heartburn medicine). Twenty-two healthy adults took both drugs in a set order, and researchers measured drug levels in their blood. The goal was …

This early-stage study tested a single dose of the experimental drug DR-01 in 32 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection under the skin. The goal was to check for side effects and measure d…

This early-stage study tested an experimental drug called SAGE-904 in 22 healthy adults to see how it affects brain electrical activity. Participants received either the drug or a placebo, then were given ketamine to temporarily mimic certain brain changes. The goal was to measur…

This early-stage study tested a new drug, A-005, in 135 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and some had a spinal tap to measure drug levels in the brain fluid. The study does not aim to treat any …

This study looked at whether a single dose of varegacestat changes the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants received the drug, a placebo, or a positive control in random order. The goal was to gather safety information, not to treat any dis…

This study looked at how the body processes the drug omaveloxolone (SKYCLARYS®) when taken as a whole capsule versus when the capsule contents are sprinkled over low-fat, non-Greek yogurt. 52 healthy adults each took the drug both ways, with a 14-day break in between. The goal wa…

This study tested whether different versions of a CGRP receptor antagonist (a type of migraine medicine) are absorbed and processed by the body in the same way. It involved 64 healthy adults aged 18 and older who received a single dose of each formulation. The goal was to see if …

This early-stage study tested a single dose of the experimental drug SAGE-718 in 22 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity, safety, and how the body processes it. The goal was to gather information, not to treat…

This study involved 49 healthy volunteers to test a new MRI technique that can trace nerve pathways in the spinal cord. The goal was to see if it's possible to create a detailed map, or atlas, of these pathways. This atlas could help doctors better understand and treat spinal cor…

This study looked at 120 healthy volunteers to see how well three different methods (clinical observation, photography, and a special imaging system called EOS) measure pelvic area extension. The goal was to describe the range of motion for four common pelvic balance types. The s…

This study looked at how oxytocin, a natural brain hormone, affects pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to understand how oxytocin works in the…

This study tested three different devices (a pre-filled syringe, an autoinjector, and an on-body injector) to give the drug litifilimab under the skin. The goal was to see how the body processes the drug with each device. 404 healthy volunteers took part, and the study focused on…

This study looked at whether inflammation is linked to heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, heart scans, and tissue samples. The goal was to better understand the relationship, not to test a new…

This study looked at whether baked snacks made with cricket flour or pea flour make people feel fuller than regular wheat snacks. One hundred healthy adults tried all three snacks on different days and rated their hunger, fullness, and how much they liked the taste. The goal was …

This study looked at how different parts of the brain talk to each other. Researchers used brain scans and mild electrical stimulation to test a theory about brain waves. 157 healthy adults took part. The goal was to understand normal brain communication, not to treat any disease…

This early-stage study tested the safety of an inhaled drug called RT234 in 31 healthy adults aged 18 to 45. Researchers measured side effects and how the drug moves through the body. The goal was to gather basic safety information before testing it in people with pulmonary arter…

This study looked at how the experimental drug ABBV-1354 moves through and leaves the body in 8 healthy adult men. Participants took a single dose containing a tiny radioactive marker so scientists could measure the drug in blood, urine, and stool. The goal was to understand the …

This study looked at how people with long-term low back pain and healthy volunteers respond to pictures of everyday situations that might be painful. Researchers measured their balance, muscle activity, and heart rate while they looked at the images. The goal was to see if people…

This study looked at how the drug varegacestat behaves in people with liver problems compared to those with healthy livers. Researchers gave a single dose to 35 adults and measured drug levels and side effects. The goal was to understand if liver impairment changes how the drug i…

This study measured how much pressure different hospital bed mattresses put on the tailbone area of healthy volunteers. Researchers tested two bed systems with volunteers lying flat and with their head slightly raised. The goal was to gather data to help understand how mattress d…