HEALTHY VOLUNTEER

This study tests whether three new HIV vaccines are safe for healthy adults aged 18 to 49. Two vaccines are given as nasal sprays and one as a booster shot. Researchers will also check if the vaccines help the body fight HIV and if the viruses used in the vaccines can spread to o…

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and well-tolerated in healthy volunteers and people with type 2 diabetes. Participants receive either the study drug or a placebo as a single injection. The study lasts about 10 months and will monito…

This study looks at how a single dose of two F/TAF tablets (a common HIV prevention pill) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if a higher single dose could be used for HIV prevention.

This study looks at whether adding a foam pad to a standard lumbar belt makes it more comfortable. Researchers will recruit 15 healthy adults aged 18 to 50 without back problems. Participants will wear the belt with and without the pad and rate their comfort on a scale from 0 to …

This early-stage study tests a new drug called ABBV-295 in 24 healthy Japanese adults who are overweight or obese. The main goal is to check for side effects and how the drug moves through the body. Participants receive injections of the drug or a placebo, and researchers monitor…

This study tests whether a gentle electrical current applied to the brain during a short nap can boost restorative sleep and reduce mental fatigue. Researchers will compare brain activity and sleep quality in 25 adults who report non-restorative sleep. Participants will take two …

This study tests an investigational drug called MD-18, given as a shot under the skin, in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. About 54 participants will be randomly assigned to receive either …

This early-stage study tests whether a new tablet called UA026 is safe and how it works in the body. It involves 124 people, including healthy volunteers and those with moderate to severe plaque psoriasis. The goal is to find the right dose and check for side effects, not yet to …

This study tests the safety of Niagen Plus, an injectable form of vitamin B3, in 40 healthy adults with fatigue. Participants receive injections under the skin or into muscle for about 100 days. Researchers check for side effects and measure NAD+ levels in the blood, which may he…

This early-stage study tests a single dose of nascertib in 12 healthy Japanese adults to see how safe it is and how the body processes it. Participants are monitored for side effects and drug levels in the blood. The goal is to gather basic safety information, not to treat any di…

This early-stage study tests how two oral drugs, ABBV-722 and upadacitinib, affect each other in the body and checks for side effects. It involves 32 healthy adults who will take both drugs and have blood samples taken. The goal is to gather safety and drug-level data, not to tre…

This study looks at how the body processes different doses of the experimental drug atirmociclib when taken with food. It involves 72 healthy adults aged 18 to 65. The goal is to measure drug levels in the blood and check for side effects, not to treat any disease.

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study aims to understand how ketamine works in the brain to quickly treat depression. Researchers will use brain scans, blood tests, and other measures in 150 adults with major depression and healthy volunteers. The goal is to find out why a single dose works fast but briefl…

This study collects white blood cells from healthy volunteers to help researchers develop new cancer treatments that use a person's own immune system. Participants must be 18 or older and in good health. The donation process, called apheresis, takes 4-6 hours and can be repeated …

This early-stage study looks at how a new drug, NX-5948, is absorbed in the body when taken as a tablet versus a capsule, and whether food or an acid-reducing drug changes that. It involves 18 healthy adults aged 19-55 who do not smoke. The goal is to gather information to help d…

This early-stage study tests a new drug called HB2198 in 32 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo and are monitored for about two months. The study focuses on safety and drug levels in the bl…

This study aims to find out what physical and mental factors make female rugby and basketball players in Saudi Arabia more likely to get injured. Researchers will measure muscle strength, fitness, and psychological traits like confidence and resilience in 60 athletes aged 18-35. …

This study tests whether a drink containing ketones can change how healthy people breathe. Twenty volunteers will be monitored in a sleep lab after taking the drink or a placebo. The goal is to see if ketones might one day help with conditions like sleep apnea or high-altitude br…

This early-stage study tests an inhaled powder called AN01 in 24 healthy adults to see if it is safe and how the body processes it. AN01 is being developed as a possible treatment for COPD, a lung disease that makes breathing hard. The study does not offer any direct treatment be…

This study aims to understand why the protection from COVID-19 vaccines decreases over time. Healthy adults aged 18 and older who are scheduled to receive a new vaccine or booster will give blood samples and health updates over one year. The goal is to learn how the immune system…

This early-stage study is testing an experimental drug called emraclidine in healthy adults aged 65 and older. The main goals are to see how the drug moves through the body and to check for any side effects. About 40 participants will receive either the drug or a placebo. This re…

This study looks at how a gene called ZIP8 may influence alcohol drinking and brain activity. Healthy volunteers aged 21 to 60 with European ancestry will receive alcohol through an IV and can press a button to get more. They will also have brain scans and complete tasks. The goa…

This early-stage study tests the safety of a new drug called TRX-100 in 24 healthy adults aged 18 to 65. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The goal is to gather essential safety informa…

This early-stage study tests a new drug called ABBV-1042 in 48 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose (or a placebo) and are monitored for side effects, vital signs, and drug levels in the blood. This study does not a…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study uses a radioactive tracer and PET/CT scans to measure lung inflammation in people who vape nicotine or cannabis, compared to cigarette smokers and non-smokers. Researchers aim to understand how different smoking habits affect lung health. The study is currently recruit…

This early-stage study is testing a new drug called PN-881 in 142 healthy adults aged 18 to 65. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measu…

This study looks at how a new drug called ABBV-722 affects the levels of birth control hormones in the body. Researchers will give the drug to 16 healthy volunteers and measure how their bodies process the birth control pill. The goal is to see if the drug changes how well the bi…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with genetic immune defects and healthy volunteers. The goal is to understand t…

This early-stage study tests the safety of a new drug called MT-201 in healthy adults aged 19 to 55. Participants receive either the drug or a placebo to check for side effects and how the body processes the drug. The goal is to gather initial safety data before testing in patien…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This early-stage study tests whether a new drug, TL-003, is safe in healthy adults and people with ulcerative colitis. About 48 participants will receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to gather initial …

This study tests three ways of combining mental movement practice (motor imagery) with tendon vibration in 33 healthy adults aged 18-50. The goal is to see which method best boosts brain activity linked to movement. Results will help design better rehab tools for people who canno…

This study tests how three common drugs (fluconazole, itraconazole, and carbamazepine) change the way the body processes a new experimental cancer drug called ASP3082. About 54 healthy adults will receive ASP3082 alone and then with each of the other drugs. The goal is to measure…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, and arthritis. About 200 adults will get a tiny amount of radioactive tracer and be scanned for up to 3 hours. The goal is to see if…

This early-stage study is testing the safety of a new drug called BIIB142 in 78 healthy adults. Researchers will give increasing doses to find the highest safe amount and see how the body processes the drug. Participants are randomly assigned to receive either BIIB142 or a placeb…

This study looks at how type 1 diabetes affects the nerves that control heart rate and breathing in children. Researchers will compare 100 children with and without diabetes using simple heart recordings. The goal is to detect early signs of nerve damage, which could help prevent…

This study looks at two ways of giving a meal test to healthy adults to measure blood sugar changes. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's body size. The goal is to find out which method produces more consi…

This study tests whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for healthy adults aged 65 to 85. About 40 volunteers will receive the drug and be monitored for side effects. The goal is not to treat any disease, but to gather safety informati…

This study aims to understand why some HIV drugs cause weight gain. Healthy volunteers aged 18 to 55 will take one of four HIV medications for 4 weeks. Researchers will measure changes in blood, fat tissue, and metabolism to find early signs of weight gain.

This early-stage study tests the safety and tolerability of a single dose of ABBV-547 in about 87 healthy adults in the US and Japan. Participants are randomly assigned to receive either the drug or a placebo. The study monitors side effects and how the drug moves through the bod…

This study aims to learn more about diseases that affect the salivary glands, which can impact quality of life. Researchers will collect medical information, saliva, blood, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is …

This study collects blood, urine, stool, and other samples from up to 150 healthy volunteers aged 18 to 85. Researchers will use these samples to compare with those from patients who have too many eosinophils (a type of white blood cell) in their body. The goal is to better under…

This study uses brain scans to measure blood flow changes in the brain while healthy adults do tasks like looking at objects, recognizing them, and remembering them. The goal is to understand how the brain works during these activities. Participants must be healthy, aged 18 to 65…

This study looks at whether a natural supplement called urolithin A can help the body release more insulin and control blood sugar in healthy adults aged 55 and older with a BMI of 27 or higher. Participants will take either urolithin A or a placebo daily for 8 weeks and undergo …

This study aims to recruit up to 2,000 healthy adults aged 18-70 to serve as a reference group for mental health research at the NIH. Volunteers complete online surveys, in-person interviews, and optional brain scans. Their de-identified data will be shared with scientists worldw…

This early-phase study tests the safety of a new drug called BIIB145, which is being developed for multiple sclerosis (MS). Since this is the first time the drug is given to people, it involves 104 healthy adults to see how the body handles it and if it causes any side effects. P…

This study tests a new drug, ENX-205, in 60 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. Some also get a brain scan to see where the drug goes. This is early research with no direct healt…

This early-phase study looks at whether reducing high insulin levels with an SGLT2 inhibitor can improve heart and blood sugar health in people with type 1 diabetes. Researchers will compare results with people who have a mild genetic form of diabetes (GCK-MODY) and healthy volun…

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam etzadroxil) in about 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Results will help decide if further studies are po…

This study aims to make MRI and MRS scans better at measuring chemicals in the brain and muscles. Researchers will test new imaging methods in 300 healthy adults aged 18 to 65. Participants will have a medical checkup and one or two scanning sessions. The goal is to improve the t…

This study aims to collect normal hearing and balance test results from 500 healthy volunteers aged 5 to 80. Participants will undergo various hearing and balance tests during a single visit to the NIH Clinical Center. The data will help doctors know what test results are normal …