BRAIN METASTASES

This study tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) in 46 adults with non-small cell lung cancer that has spread to the brain and has not been treated before. The goal is to see how well the drugs shrink brain tumors. Treatment c…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them from growing back. About 46 adults with cancer that has spread to the brain will take part. The goal is to improve tumor control, not to cure the disease…

This study is for people with brain metastases (cancer that has spread to the brain) that are considered low-risk. Researchers want to see if adding precise radiation (stereotactic radiosurgery) after initial drug therapy can better control the disease in the brain. About 316 adu…

This study tests two ways to treat lung cancer that has spread to the brain. One group gets focused radiation plus a drug called bevacizumab; the other gets whole-brain radiation that tries to protect the memory center. The goal is to see which approach better controls the brain …

This study is for people whose brain tumors have returned after radiation therapy. It compares a laser-based treatment (LITT) with standard care to see which better controls tumor growth and reduces the need for steroids. About 261 adults with brain metastases will take part.

This study looks at the best time to give radiation for people having surgery to remove brain metastases (cancer that has spread to the brain). It compares three options: radiation before surgery, during surgery, or after surgery. The goal is to see which timing best prevents the…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 104 participants will receive the combination treatment. The main goal is to see how man…

This study tests whether adding a 2mm safety margin around brain tumors during radiosurgery (a precise radiation treatment) works better than no margin. About 180 adults with brain metastases up to 4cm will be randomly assigned to one of the two margin sizes. The goal is to see w…

This study tests whether two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. About 120 adults with certain cancer types (like BRCA-mutated or lung cancers) and growing brain tumors will receive the combination. The goal is to slow or …

This early-stage study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, or related mutations). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. …

This study tests whether combining the drug pembrolizumab with precise radiation can help control breast cancer that has spread to the brain. About 41 adults with at least two brain tumors will receive the drug every three weeks and radiation to one tumor. The goal is to see if t…

This study looks at two types of radiation for people with 4 to 15 brain tumors that have spread from other cancers. One is a precise, short treatment called CyberKnife, and the other is whole-brain radiation given over 10 sessions. The goal is to see which approach helps patient…

This study tests whether adding the drug abemaciclib to targeted radiation can better control breast cancer that has spread to the brain. It is for people with a specific type of breast cancer (HR+/HER2-). The goal is to see how long the brain tumors stay under control. About 31 …

This study is for people whose brain tumors have come back after initial radiation. It tests using either laser heat therapy or surgery, followed by another round of targeted radiation, to control the tumors. The goal is to see if this approach is safe and helps manage the diseas…

This study looks at people with a specific type of lung cancer that has spread to the brain but isn't causing major symptoms. Half get alectinib alone, the other half get alectinib plus targeted brain radiation. The goal is to see if delaying radiation keeps the brain healthy and…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This early-stage trial is testing whether personalizing standard radiotherapy based on how a patient's tumor responds can be safe and effective. It includes two groups: one for extensive-stage small cell lung cancer patients receiving chemoimmunotherapy, and another for people wi…

This study compares two standard radiation techniques for people with large brain metastases (tumors that spread from other cancers). The goal is to see which method better controls tumor growth and reduces the need for additional treatments or steroids. About 54 adults will be r…

This study tests whether adding a nitroglycerin patch (a heart medication) to standard radiation therapy can better shrink brain tumors in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the brain. About 74 adults will be ran…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and are safe. About 33 adults whose melanoma worsened after imm…

This study tests a drug called repotrectinib in people with a specific type of lung cancer (ROS1-positive non-small cell lung cancer) that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. About 20 adults will take the drug by mouth, and …

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 adults with this condition will receive the combination and be monitored for side effects and tumor response. The goal is to find a better treat…

This study tests whether a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) can stop or slow the growth of kidney cancer that has spread to the brain. About 20 adults with untreated brain metastases will receive the drugs. The goal is to see if this approach i…

This study tests whether a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) can shrink or stabilize melanoma tumors that have spread to the brain. About 60 adults with melanoma brain metastases will receive the drugs intravenously. The main goal is…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a special PET/CT scan (18F-Fluciclovine) to see if it can better detect brain metastases and tell the difference between active cancer and scar tissue from treatment. About 20 adults with known or suspected brain metastases will get the scan before and after thei…

This study aims to see if a special MRI technique called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases will be scanned. If CEST works a…

This study tests whether a special PET scan called Axumin can help doctors tell the difference between actual tumor growth and harmless inflammation in people with brain metastases who are on immunotherapy. About 20 adults with brain metastases will get the scan to see if it impr…

This study is for people with small-cell lung cancer who choose not to have preventive brain radiation. It compares a powerful 7T MRI to the usual 1.5T/3T MRI to see if it can detect very small brain metastases earlier. About 20 participants will get both scans over time. The goa…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. If…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain metastases will receive an extra brain scan (FES PET/CT) before their standard radiation treatment. Researchers will compare th…

This study tests a faster MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can clearly tell the difference between a brain tumor coming back and brain damage from radiation therapy. About 90 people will join, including healthy volunteers, people with new …

This study looks at whether people with brain metastases can safely avoid the steroid dexamethasone before and after surgery. About 35 adults with new brain tumors and a suspicious or confirmed cancer elsewhere will be enrolled. The main goal is to see how many need to start dexa…

This study is for people with brain metastases (cancer that spread to the brain) who have not had brain radiation before. Researchers want to find the highest safe dose of a precise radiation treatment called stereotactic radiosurgery. About 50 participants will receive different…

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. The ma…

This study tests a special way of delivering whole-brain radiation (called pulsed reduced dose-rate) to see if it causes fewer memory and thinking problems. About 53 adults with solid tumors that have spread to the brain will receive 10 daily treatments. The goal is to complete t…

This study is testing a new program called the Cognitive Stepped Care Program (CSCP) for adults with brain metastases. The program screens for thinking and memory problems and offers different levels of support, from education to one-on-one coaching. Researchers want to see if th…

This study compares two radiation approaches for people with 5 to 15 brain metastases from cancers that are not blood cancers. One group gets focused radiation only to the tumors (SRS), while the other gets whole-brain radiation that avoids the memory center plus a drug to protec…

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. It involves 60 adults with stage III non-squamous lung cancer. The goal is to see if early detection can reduce the number of…

This study is testing whether a special PET scan using 18F-Fluciclovine can help doctors see how brain tumors respond to a precise type of radiation called stereotactic radiosurgery (SRS). About 46 adults with brain metastases (tumors that spread from other cancers) will get the …

This study compares two ways of aiming radiation at brain tumors that have spread from other cancers. Half the participants get the standard extra 2 mm safety margin around each tumor, while the other half get no extra margin. The goal is to see if skipping the margin keeps tumor…

This study aims to develop and test a new MRI technique that may help doctors tell the difference between actual tumor growth and changes caused by radiation treatment in people with brain metastases. About 119 participants, including healthy volunteers and patients, will undergo…

This study looks at whether using an MRI scanner during brain surgery helps surgeons remove brain metastases more completely. About 154 adults who need surgery for brain tumors will take part. The goal is to see if this advanced imaging leads to better outcomes and fewer repeat p…

This study looks at whether a special PET scan using an investigational agent called 18F-Fluciclovine can find leftover tumor in people who had brain metastasis surgery and are scheduled for radiation. About 20 adults will get an optional PET scan before radiation. The goal is to…

This study tests a new approach called pharmacoscopy, which quickly checks how a patient's own brain tumor cells respond to different drugs in the lab. The goal is to see if this personalized method helps doctors choose better treatments for people with brain metastases who have …

This study looks at inflammation in brain tumors using a special PET scan tracer called [C-11]-CS1P1. About 104 adults with brain cancer that hasn't been treated with radiation will get a baseline scan and a follow-up scan within 24 months. The goal is to see how inflammation pat…

This study is testing a new MRI technique called CEST to create detailed maps of acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients to see if pH levels can help predict where tumors might return or how long patients survive. The goal …

This study looks at tissue samples from 30 people with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic features of the original tumor and the brain tumor to see if they differ. The goal is to understand how the cancer changes when it spreads…

This study explores a new type of MRI that looks at how brain tumors use energy, which may help doctors predict which tumors will respond to radiation therapy. Researchers will scan 276 healthy volunteers and patients with brain metastases before and after stereotactic radiosurge…

This study uses special MRI scans to see how radiation treatment for brain tumors affects thinking and memory. Researchers will follow 15 people with newly diagnosed brain metastases who are getting stereotactic radiosurgery. The goal is to better understand the brain changes tha…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…