BRAIN METASTASES

This study tests an experimental drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain. It aims to see if the drug is safe and can shrink or control brain tumors, including cases where cancer has reached the lining of the brain. Participa…

This study tests whether a higher dose of furmonertinib alone works better than a standard dose combined with chemotherapy for people with a specific type of lung cancer (EGFR-mutated) that has spread to the brain. About 60 adults who have not had treatment before will take part.…

This early-phase study tests a new treatment for adults whose cancer has spread to the brain. The therapy uses a patient's own immune cells, modified to better target and attack tumor cells. The main goals are to see if the treatment is safe and possible to give, with 12 particip…

This early-phase study tests a drug called trastuzumab deruxtecan (T-DXd) combined with precise radiation (SRS) for people with HER2-positive breast cancer that has spread to the brain. The goal is to find the safest dose of the drug when given with radiation and to see how well …

This study compares two radiation schedules for people with 1 to 5 brain tumors that come from cancers like melanoma or kidney cancer. Participants will get high-dose radiation over either 3 days or 5 days. The goal is to see if the shorter schedule controls the tumors better at …

This early-phase study tests whether a special cancer vaccine (SV-BR-1-GM) combined with an immunotherapy drug (pembrolizumab) is safe and feasible for people with solid tumors that have spread to the brain or spinal cord. About 20 adults whose cancer has worsened after standard …

This study tests whether adding a targeted drug (dalpiciclib) and hormone therapy to brain radiation can help control breast cancer that has spread to the brain. About 46 women with HR-positive, HER2-negative advanced breast cancer will receive the combination treatment. The goal…

This study is for people whose cancer has spread to the brain. It compares two types of whole brain radiation: one that avoids the memory center (hippocampus) and one that avoids several brain areas linked to thinking. The goal is to see which approach better protects memory and …

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for outlining tumors and healthy organs before radiation therapy. About 80 adults with brain, bone, head/neck, or lung cancer will get both scans, and doctors will compare how accurately the…