BRAIN METASTASES

This study tests the drug lorlatinib in people with a specific type of lung cancer (ALK-positive) that has spread to the brain or the lining of the brain and spinal cord. The goal is to see how well the drug shrinks these brain tumors. About 41 adults will take part, and the stud…

This study tests giving a focused, high-dose radiation treatment (hypofractionated stereotactic radiosurgery) before surgically removing brain metastases. The goal is to see if this approach delays tumor regrowth compared to standard care. About 49 adults with solid tumors that h…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study tests an experimental drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. Participants receive the drug and are monitored for side effects and tumor respons…

This early-stage study is testing whether giving two cancer drugs (cabozantinib and nivolumab) along with radiation therapy is safe for people with kidney cancer that has spread to the brain. Only 2 participants were enrolled to closely monitor side effects, especially those affe…

This early-phase study tests the safety of a drug called GDC-0084 when given together with radiation therapy. It is for people whose cancer has spread to the brain or the lining of the brain and who have a specific genetic change (PIK3CA mutation). The main goal is to find the hi…

This study looks at whether adding stereotactic radiotherapy (precise radiation) to standard targeted drug therapy can better control brain metastases in people with non-small cell lung cancer. About 202 participants who have a specific gene mutation (EGFR) and brain tumors that …

This study tests whether adding a precise type of radiation (stereotactic radiosurgery) to a three-drug combination (binimetinib, encorafenib, and pembrolizumab) can better control melanoma that has spread to the brain in people with a specific BRAF gene mutation. Ten adults with…

This study tests a new way to deliver radiation to the brain right after tumor removal, using a special tile called GammaTile. It compares this to the usual approach of waiting 3-4 weeks after surgery for standard radiation. The trial includes 230 adults with 1 to 6 new brain met…

This study tests whether the immunotherapy drugs nivolumab and ipilimumab, alone or together, can shrink melanoma tumors that have spread to the brain. It involves 76 adults with stage IV melanoma and at least one brain metastasis. The main goal is to see how many patients have t…

This study is for people with advanced HER2+ breast cancer whose cancer has spread to the brain but is stable elsewhere. Participants will continue their current treatment and add the drug tucatinib to see if it can delay or prevent new brain tumors. The goal is to improve contro…

This early-phase study tests whether a special PET scan (68Ga-PSMA-11) can spot active tumor tissue in people with high-grade glioma or brain metastases. Eleven adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive the scan befor…

This study tests a new type of PET/MRI scan to tell the difference between a brain tumor growing back and a side effect of radiation called radionecrosis. Both conditions look very similar on regular scans and cause similar symptoms, so doctors often need surgery to find out whic…

This study tests whether an extra MRI scan, taken later than usual, can better tell apart tumor regrowth from radiation damage in people with brain metastases who had radiosurgery. About 25 adults with a history of treated brain tumors will get this special MRI, and results will …

This study aimed to see if giving a second round of whole brain radiation could help people with cancer that has spread to the brain stay independent longer. It was designed for patients who could not have surgery or focused radiation. However, the study was withdrawn before any …

This early-phase study tests giving focused radiation to brain tumors before surgical removal, aiming to protect healthy brain tissue and possibly eliminate the need for radiation after surgery. About 25 adults with brain metastases (tumors that spread from other cancers) will re…

This study looks at how radiation treatment affects memory in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will receive focused radiation to each tumor. The goal is to find the safest radiation dose and measure any memory decline over 4 …

This study looks at how radiation treatment for brain tumors that have spread from other cancers affects thinking and memory. Researchers will use new MRI techniques before and after radiation to see if they can spot early signs of cognitive decline. 110 patients will be followed…

This study looks at whether artificial intelligence can analyze routine brain MRI scans to predict specific genetic changes (EGFR or ALK) in non-small cell lung cancer that has spread to the brain. Researchers will use scans from 380 patients across multiple hospitals to train an…

This study looks at two types of radiation therapy for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, and the other gets whole-brain radiation plus SRS. The goal is to see which approach better protects memory a…

This study reviews medical records from 230 adults across 15 hospitals in 2 countries to understand how brain metastases from stomach and esophageal cancers are treated. The goal is to see which local treatments (like surgery or radiation) work best and how long patients live aft…

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes thinking or memory problems. About 80 adults with brain metastases or benign meningiomas will take memory tests and quality-of-life surveys before and after treatment. Rese…