BRAIN METASTASES

This study is for people with a specific type of advanced skin cancer (melanoma) that has spread to the brain. It tests whether adding a precise, high-dose radiation treatment (stereotactic radiosurgery) to a combination of three drugs works better than the drugs alone. The goal …

This early-phase study is testing whether combining two cancer drugs (cabozantinib and nivolumab) with targeted radiation is safe for people with kidney cancer that has spread to the brain. The main goal is to see if patients can tolerate this intensive combination without severe…

This study is testing a focused radiation treatment called stereotactic radiosurgery for patients with six or more brain metastases (tumors that have spread to the brain). The first goal is to find the safest, most effective dose. The second goal is to measure how much the treatm…

This study is for people with advanced HER2+ breast cancer that has spread to the brain. It tests whether adding a drug called tucatinib to their current standard treatment can better control the cancer in the brain and delay its progression there. Participants will continue thei…

This study is testing whether an investigational drug called QBS72S can shrink tumors that have spread to the brain from breast or lung cancer. It involves 21 adults with advanced cancer that has spread to the central nervous system. Researchers will measure how well the drug wor…

This study compares two ways to deliver radiation after surgery to remove brain tumors that have spread from cancer elsewhere in the body. It tests whether placing small, dissolvable radiation tiles (GammaTile) directly in the tumor cavity during surgery works better than the sta…

This study is testing whether two immunotherapy drugs, nivolumab alone or nivolumab combined with ipilimumab, can help control melanoma that has spread to the brain. It enrolled 76 adults with these brain metastases. The goal is to see if these drugs, which help the immune system…

This study is for people with a specific type of advanced lung cancer that has spread to the brain. After initial treatment with targeted drugs, if only a few small brain tumors remain, the trial tests whether adding a very precise form of radiation (stereotactic radiotherapy) ca…

This study is testing if giving a short, focused course of radiation right before surgery helps keep brain tumors from coming back longer than the current standard approach. It involves 49 adults with cancer that has spread to the brain from elsewhere in the body, where the main …

This study is testing if a special combined scan (FLT-PET/MRI) can tell the difference between two problems that look the same after brain radiation treatment: radiation damage and the cancer growing back. It aims to see if this scan can provide a clear answer without needing bra…

This study is testing a new type of PET scan to see if it can effectively show activity in aggressive brain tumors. It involves adults with high-grade gliomas or brain metastases who are already scheduled for a biopsy or surgery. The goal is to see if this scan can provide cleare…

This study is testing a new artificial intelligence (AI) tool designed to help doctors treat lung cancer that has spread to the brain. The tool analyzes standard brain MRI scans to predict whether a patient's cancer has specific genetic markers (EGFR or ALK), which determine the …

This study aims to understand how radiation treatment for brain metastases affects brain function and memory over time. Researchers will follow 110 patients for two years, using advanced MRI scans and cognitive tests before and after treatment. The goal is to identify early signs…

This study looks back at the medical records of 230 patients to understand how different treatments for brain metastases from stomach or esophageal cancer affect survival. Researchers are comparing surgery, radiation, and combinations of these treatments. The goal is to find whic…