BRAIN METASTASES

This study tested a drug called furmonertinib in 24 adults with a specific type of advanced lung cancer (EGFR-mutant NSCLC) that had spread to the brain. The goal was to see how well the drug controlled brain tumors and how safe it was. Participants took the drug and were monitor…

This study tested giving a precise, high-dose radiation treatment before surgery to remove brain metastases in 70 adults with cancer. The goal was to see if this approach could better control tumor regrowth at 6 months. Participants had up to 4 brain tumors from breast, digestive…

This study tested a new drug called AZD3759 against standard targeted therapies (gefitinib or erlotinib) in 492 adults with advanced lung cancer that has a specific gene mutation (EGFR) and has spread to the brain. The goal was to see if AZD3759 could better delay cancer growth. …

This early-phase study tested whether giving a type of focused radiation (stereotactic radiosurgery) after an immunotherapy drug (nivolumab) is safe and can help control breast cancer that has spread to the brain. Fourteen adults with up to 10 brain metastases took part. The main…

This pilot study tested a new order of treatment for people with brain metastases (cancer that spread to the brain). Instead of surgery first, patients received focused radiation (gamma knife) before surgical removal of the tumor. The study included 11 adults with 1 to 4 brain tu…

This study tested a new approach for people with large brain metastases (tumors that spread to the brain from other cancers). Instead of surgery first, patients received focused radiation before surgery to remove the tumor. The goal was to see if this order reduces side effects a…

This study tested whether an early F-DOPA PET scan can distinguish between brain tumor recurrence and radiation necrosis (scar tissue from radiotherapy) in 8 adults with brain metastases. The approach uses a new, more sensitive PET scanner to capture rapid images within 4 minutes…

This study tested a new MRI contrast agent called RVP-001 in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions without using gadolinium, a metal that can build up in the bo…

This study tested whether a special type of PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than the standard MRI. Researchers looked at 32 patients with lung cancer, breast cancer, or melanoma who had untreated brain metastases. The goal was to s…

This study tested a counseling program called CALM (Managing Cancer and Living Meaningfully) for people with malignant brain cancer. The goal was to see if it's practical and helpful for reducing distress like depression and anxiety about death. 60 participants were offered eithe…

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases (tumors that spread to the brain from other cancers). It included 13 adults with tumors between 2 and 6 cm. The goal was to find the highest dose that does not c…

This study looked at the genetic and epigenetic changes in brain metastases from solid cancers. Researchers compared tumor tissue with liquid biopsies (blood and spinal fluid) from 21 patients to see if less invasive tests could reveal the same molecular information. The goal was…

This early study tested whether it is safe to temporarily open the blood-brain barrier using focused ultrasound in 8 people with HER2-positive breast cancer that spread to the brain. The goal was to see if the procedure could be done without causing serious side effects. The stud…

This study gathered information from 968 people who received or were scheduled to receive a special type of radiation called HyperArc for brain tumors. The goal was to collect data to see how effective this treatment is compared to other options. Researchers looked at survival ra…