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New study: can targeted radiation save thinking skills in patients with multiple brain tumors?

NCT ID NCT02953717

Knowledge-focused Sponsor: Elisabeth-TweeSteden Ziekenhuis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of radiation for people with 11 to 20 brain tumors that spread from other cancers. One group got Gamma Knife radiosurgery, which targets each tumor precisely. The other got whole brain radiation, which treats the entire brain. The goal was to see which approach better protects memory and thinking. 81 patients took part, and researchers measured cognitive decline three months after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gamma Knife radiosurgery and whole brain radiation therapy
What this could lead to
If Gamma Knife causes fewer memory and thinking problems, it could become the preferred treatment for patients with multiple brain metastases.
What could go wrong
This is a small, completed study with only 81 participants. Results may not apply to all patients, and Gamma Knife may not control tumors as well as whole brain radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

81 people

The number who actually took part.

Start date

Feb 2016

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically proven malignant cancer * 11-20 newly diagnosed brain metastases on a triple dose gadolinium-enhanced MRI-scan * Maximum total tumor volume ≤ 30 cm3 * Lesion ≥ 3 mm from the optic apparatus * Age ≥ 18 years * Karnofsky Performance Status (KPS) ≥ 70 * Anticipated survival \> 3 months Exclusion Criteria: * No prior histologic confirmation of malignancy * Primary brain tumor * A second active primary tumor * Small cell lung cancer (SCLC) * Lymphoma * Leukemia * Meningeal disease * Progressive, symptomatic systemic disease without further treatment options * Prior brain radiation * Prior surgical resection of BM * Cardiovascular accident (CVA) \< 2 years ago * Additional history of a significant neurological or psychiatric disorder * Contra indications to MRI or gadolinium contrast * Underlying medical condition precluding adequate follow-up * Participation in a concurrent study in which neuropsychological testing and/or health-related QOL assessments are involved * Lack of basic proficiency in Dutch * IQ below 85 * Severe aphasia * Paralysis grade 0-3 according to MRC scale (Medical Research Council)

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Conditions

The condition(s) this trial relates to.

anxiety disorder brain cancer Depression Fatigue metastatic malignant neoplasm in the brain metastatic neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neoplasm metastasis

Contacts and locations

Locations

  • Gamma Knife Center Tilburg, Elisabeth-TweeSteden Hospital

    Tilburg, North Brabant, 5022 GC, Netherlands

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