Thrombotic disease

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This study tests an investigational medicine called ARD001, designed to treat hemophilia A, a bleeding disorder. In the first phase, healthy adults receive a single dose of ARD001 or a placebo to check safety and how the drug behaves in the body. If that goes well, a second phase…

This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a place…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This pilot study tests whether omeprazole, a common heartburn drug, can reduce gastrointestinal bleeding in adults 65 and older who take blood thinners for blood clots. Researchers will enroll 360 participants to see if a larger trial is feasible. The study focuses on recruitment…

This trial tests whether using a suction catheter to remove large blood clots before placing a stent improves outcomes in people having a severe heart attack (STEMI). Participants must have a large clot visible on angiography. Half receive standard stent placement alone, and half…

This study tests whether taking two blood thinners (aspirin and clopidogrel) for 12 months after leg artery surgery is better than taking them for just 1 month in people with severe leg artery disease. The goal is to see if longer treatment prevents amputations or death. About 61…

This trial compares two blood products—prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP)—for controlling bleeding in people undergoing heart valve surgery. Doctors use a special test to guide which product to give and measure how quickly bleeding stops. The goal…

This study tests whether using HEPA air filters at home can slow the progression of heart disease in adults aged 65-84 who have a history of ischemic heart disease. Over 112 participants in Los Angeles will use real or sham filters for several months, and researchers will measure…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This study tests whether a specially adjusted dose of the blood thinner apixaban can safely treat blood clots in cancer patients who also have low platelet counts. About 30 adults with active cancer and a recent clot will receive the adjusted dose. The goal is to see if this appr…

This study is testing a device called the NeVa stent retriever to see how well it can remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass. The study will enroll 600 adults who are already scheduled to have this proc…

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to …

This study looks at 128 people with advanced heart failure who have a HeartMate3 heart pump. All take warfarin to prevent clots, and half will also stop taking aspirin. The goal is to see if skipping aspirin lowers the risk of serious bleeding without raising the chance of danger…

This study tests whether using only low-dose blood thinners (instead of the standard full-dose) is safe for patients on a life-support machine called ECMO for severe lung failure. The goal is to see if this approach reduces dangerous bleeding while still preventing clots. Forty a…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a new drug called TBO-309, which helps prevent blood clots, in people having a stroke. It is given alongside standard treatments like clot-busting drugs or mechanical clot removal. The main goal is to see if it is safe, especially regarding bleeding in the brain,…

This study tests a drug called Fortelyzin, which is injected directly into blood clots to dissolve them, in people with acute limb ischemia (sudden loss of blood flow to a limb). The goal is to see if it can prevent amputation as well as or better than standard surgery. About 170…

This study tests whether apixaban (a pill taken twice a day) is a safe and more satisfying alternative to enoxaparin (a daily shot) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researc…

This study compares two ways to repair a common type of meniscus tear in the knee. One group gets standard stitches, the other gets stitches plus a fibrin clot made from the patient's own blood to help healing. The trial will enroll 120 people aged 18-50 and check if the meniscus…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during liver transplant surgery. The device measures blood clotting in real time. Researchers hope it will reduce bleeding and the amount of blood products needed. The…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

Researchers are testing a radioactive tracer called 18F/68Ga-GP1 that binds to a protein found on blood clots. Adults with suspected, newly diagnosed, or previously treated thrombi receive one intravenous injection and then undergo PET/CT or MRI imaging. The study measures how mu…

Researchers are studying whether thromboelastography, a blood test that measures clot formation, can predict outcomes for people having surgery for glial brain tumors. The trial enrolls about 100 adults who are scheduled for tumor removal or biopsy. By tracking clotting measureme…

This study tests a new PET scan that uses a special tracer to find blood clots inside the heart. It involves 20 people with cardiac amyloidosis and atrial fibrillation. The goal is to see if this scan can spot clots better than current methods, which could help prevent strokes.

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study uses a new type of CT scan (photon counting CT) to detect blood clots caused by central venous catheters. Researchers will first scan deceased patients who have a catheter and compare the results to an autopsy. Then they will scan living patients with a catheter to see…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study is testing a new blood test called Cryocheck HexLA to see if it can detect lupus anticoagulant (LA) more accurately than current tests. Researchers will compare the new test with standard tests using blood samples from 200 adults. The goal is to find a test that is bot…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study tests a small, battery-powered device called ClotChek™ that measures how fast a patient's blood clots using a fresh drop of blood. Researchers want to see if it can tell the difference between people on common blood thinners (rivaroxaban or apixaban) and those not on a…

This Phase 2 trial tests whether a single dose of gruticibart, a monoclonal antibody, can prevent blood clots that often form when a central venous catheter is placed. About 90 adults getting a catheter will receive either the drug or a placebo. The goal is to see if gruticibart …

This study looks at the best way to prevent blood clots in people who have a leg cast or splint after an injury. For those at high risk of clots, it compares pills to standard injections. For low-risk people, it checks if any medication is better than just advice. Over 10,000 par…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people having a stroke caused by a blocked vessel. Participants are adults who are already scheduled for endovascular therapy, a pr…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants give about 10 tablespoons of blood at the NIH Clinical Center and may return for up to 10 years. The samples will be …

This study from the National Human Genome Research Institute aims to better understand Congenital Disorders of Glycosylation (CDG), a group of rare genetic conditions that affect how the body attaches sugars to proteins and fats. Researchers will examine up to 200 participants, i…

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergo…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study aims to learn how platelets—blood cells that help with clotting and healing—work in healthy people over time. Researchers will collect blood samples and health information from 400 volunteers aged 18 and older every 6 to 7 months for up to 10 years. The goal is to unde…

This study is collecting blood samples from 35 adults with a type of blood cancer called myeloproliferative neoplasm (MPN) who have a specific genetic mutation (CALR). Researchers want to understand why patients with a different mutation (JAK2) have a higher risk of dangerous blo…

This observational study will follow 1300 critically ill adults in intensive care to see if a blood test called anti-factor Xa activity can predict dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, quality of life, and…

This study is tracking 2000 patients with moderate to severe pulmonary embolism (blood clots in the lungs) who undergo a procedure called computer-aided vacuum thrombectomy, where a special tube sucks out the clot. Researchers want to see how well the procedure works and what com…

This study is collecting blood and urine samples from 150 cancer patients who have had blood clots. The goal is to learn more about why clots happen in cancer and how to prevent them. Participants will be followed over time to track clot recurrence and bleeding risks.

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study looks at two different methods (one-needle vs two-needle) for placing a PICC line, a long-term IV used for treatments like chemotherapy. About 284 adults who need a PICC for the first time will take part. The goal is to find out which method leads to fewer complication…

This study looks at people who use nitrous oxide (laughing gas) for fun, some with and some without nerve problems like trouble walking or numbness. Researchers want to find blood markers that show how the gas harms the body, which could lead to better monitoring and care. About …

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study is creating a global registry of 500 adults with antiphospholipid syndrome (APS) who are taking direct oral anticoagulants (DOACs) like rivaroxaban or apixaban. Researchers will track rates of recurrent blood clots and bleeding over at least 6 months. The goal is to ga…

This early-stage study tests the safety of a new drug called CAY001 in 24 healthy adults aged 18-50. Participants receive a single dose of the drug or a placebo by IV, and researchers monitor them for 28 days for side effects and how the drug moves through the body. The goal is s…

This study looks at how blood clotting works differently in the liver's portal vein compared to the rest of the body in people with liver cirrhosis. Researchers will take blood samples from 45 patients during a routine procedure called TIPS, which helps relieve high blood pressur…

This study is a large registry that collects health information from up to 200,000 people with blood disorders such as hemophilia, thrombosis, and sickle cell disease. Participants are seen at Hemophilia Treatment Centers across the U.S. The goal is to gather real-world data to h…

This study involves over 12,000 Chinese patients with coronary heart disease who take blood thinners. The goal is to find new biological markers that can better predict who is at risk for dangerous blood clots or major bleeding. Researchers will combine genetic, protein, and imag…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study is testing whether an artificial intelligence system can predict serious complications in people hospitalized with a pulmonary embolism (a blood clot in the lungs). Researchers will analyze CT scans from 2,000 adults to see if the AI can identify who is likely to die o…

This study looks at whether information from CT scans, along with lab tests, can predict which patients with a blood clot in the lungs (pulmonary embolism) will have serious problems within 30 days. Researchers will collect data from 300 patients to build a prediction tool. The g…

This study will review the medical records of 10 patients who developed acute pancreatitis within two weeks after a procedure to remove blood clots (percutaneous mechanical thrombectomy). The goal is to find out how often this complication happens, what patient or procedure facto…

This pilot study aims to see if certain blood markers that indicate clotting increase when atrial fibrillation (AFib) is more active. Researchers will take blood samples from 20 adults before, during, and up to 90 days after a catheter ablation procedure. The goal is to better un…

This study will collect leftover blood samples from 10 newborns with severe heart defects who have surgery at Boston Children's Hospital. Researchers want to understand why these babies are more likely to develop dangerous blood clots after surgery. They will look at tiny molecul…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. It aims to understand bleeding risks during pregnancy and childbirth for mothers, and how children develop antibodies to factor VIII treatment. By observing families over time, researchers …

This study is looking for better ways to predict blood clots in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will measure specific markers in the blood of 300 participants to see if they can tell who is at higher risk for clots. The goal …

This study looks at leftover blood samples from 100 patients having heart surgery to see how certain immune cells (monocytes) change during the procedure. The goal is to understand links between inflammation and blood clotting risks. No new treatments are being tested; it is pure…

This study looks at whether common blood thinners like heparin can mess up lab tests for another blood thinner, argatroban. Doctors often switch patients from heparin to argatroban, but current tests can't tell the two drugs apart. Researchers will analyze blood samples from 70 a…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study looks at how blood clotting changes in pregnant women and whether these changes can predict complications like blood clots or high blood pressure. Researchers will study 100 women aged 18-40 with natural pregnancies. The goal is to use machine learning to find hidden r…

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols may be saf…

This study looks at how thick the blood is in 160 people with polycythemia (a condition with too many red blood cells). Researchers want to see if thicker blood causes more symptoms like headaches or dizziness, and how it differs between types of polycythemia. No new treatments a…

This study looks at how blood cells interact and what goes wrong in inherited bleeding disorders like Glanzmann thrombasthenia. Researchers will analyze blood samples from up to 60 healthy volunteers and patients to find genetic defects. The goal is to better understand these con…

This study looks at why cancer patients have a much higher risk of developing blood clots. Researchers will collect blood clots from 120 patients (with and without cancer) who undergo a procedure to remove clots. They will analyze the clots for cancer cells and other factors to b…

This study looks at whether giving low-risk blood clot patients a 4G tablet for remote check-ups, education, and questionnaires is practical and satisfying for patients and doctors. Fifty participants will use the tablet for up to a year while following standard treatment. The go…

This study is tracking 400 people with acute or subacute blood clots in their legs to see how well endovascular treatments (minimally invasive procedures using catheters, balloons, stents, or clot-removal devices) work. The main goal is to see how many patients avoid amputation a…