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Scientists hunt for blood clues to laughing gas nerve damage

NCT ID NCT05540561

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at people who use nitrous oxide (laughing gas) for fun, some with and some without nerve problems like trouble walking or numbness. Researchers want to find blood markers that show how the gas harms the body, which could lead to better monitoring and care. About 356 current or former users will give blood samples and report their use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 356 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients using or having recently used nitrous oxide, and hospitalized during the study will be offered to participate in the study.

Ages

14 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A current or former recreational nitrous oxide user defined * With associated clinical signs (group 1) * Without associated clinical signs (group 2) * With or without clinico-biological sequelae associated with use * Consenting to the conduct of the study * Socially insured Exclusion Criteria: * Pregnant or breastfeeding women * Never used nitrous oxide or stopped using it more than 6 months ago * Lack of social security coverage * Not willing to participate in the entire study

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Conditions

The condition(s) this trial relates to.

thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nitrous oxide abuse

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • BETHUNE

    RECRUITING

    Béthune, France

  • Boulogne Sur Mer

    RECRUITING

    Boulogne-sur-Mer, France

  • CALAIS

    RECRUITING

    Calais, France

  • Chu Lille

    RECRUITING

    Lille, France

  • Lens

    RECRUITING

    Lens, France

  • Nantes

    RECRUITING

    Nantes, France

  • Roubaix

    RECRUITING

    Roubaix, France

  • Rouen

    RECRUITING

    Rouen, France