Opiate dependence

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests different medication and counseling combinations to improve how long people stay in treatment for opioid use disorder and whether they can safely stop medication without relapsing. Over 1,500 participants choose either buprenorphine or naltrexone and are randomly…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This trial tests whether adding substance use disorder resources to existing behavioral health services in pediatric primary care clinics can improve care for adolescents with opioid use disorder. The approach includes training, stigma reduction, and brief interventions during re…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This trial tests whether giving naloxone — the opioid-overdose reversal drug — just before buprenorphine can help people who use fentanyl start addiction treatment more quickly and with less discomfort. The study enrolls a small group of adults with opioid use disorder who test p…

This study tests a program where pharmacists provide weekly phone coaching to adults who may be misusing opioid medications. The goal is to reduce risky opioid use and prevent addiction. 350 participants across 14 pharmacies are taking part in this randomized trial.

This study tests whether daily text check-ins and small financial rewards can help people with opioid use disorder stay engaged in treatment after leaving the emergency department. Participants receive automated texts for 30 days and can contact a navigator for support, while som…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This study will test whether using opioid-free anesthesia during knee replacement surgery can reduce the risk of long-term opioid use and chronic pain. About 700 adults scheduled for knee replacement will be randomly assigned to receive either standard opioid-based anesthesia or …

This pilot study aimed to help people who had an opioid overdose by starting them on buprenorphine/naloxone in the emergency room and then connecting them to an addiction clinic. The goal was to reduce repeat overdoses and improve treatment engagement. However, the study was with…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests whether adding peer recovery support—coaching from someone who has personally overcome opioid addiction—to standard medication treatment (buprenorphine) helps people stay in care longer. Fifteen adults with opioid use disorder will receive peer support for 180 da…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This study tests whether a smartphone app can help people on medication for opioid use disorder stay drug-free. The app tracks location and sends alerts when users enter high-risk areas. Researchers will also use brain scans to understand why some people do better than others. Th…

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This study tests whether adding culturally-aligned activities and healing groups to standard medication-assisted treatment (MAT) helps people with opioid use disorder stay in treatment longer and reduce harm. About 136 adults newly enrolled in the Cherokee Nation MAT program will…

This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. 240 participants from Maryland jails will receive monthly shots for six months after release. The go…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study tests whether giving a long-acting buprenorphine shot (BRIXADI) via telemedicine to 30 jailed adults with opioid use disorder helps them stay on treatment after release. Participants switch from daily pills to weekly or monthly shots before leaving jail, then continue …

This study looks at two different approaches to help community hospitals start treating opioid use disorder in patients. One approach is basic training and education, while the other adds extra support like practice facilitation. The goal is to see which method works better at ge…

This study tests whether a 90-day Mediterranean diet can lower drug cravings and improve blood health in people being treated for opioid addiction with methadone or buprenorphine. Forty adults will either follow the diet or eat as usual. The goal is to see if better nutrition can…

This study aimed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to enroll adults aged 21–70 who were not already on opi…

This study looked at whether giving a short-term buprenorphine treatment to people on probation or parole with opioid use disorder helps them stop using illegal opioids and get into long-term care. About 320 adults in Baltimore took part. The approach was compared to simply refer…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study compares standard emergency department care to an extended observation period for people with opioid use disorder. Participants are randomly assigned to either leave after a regular ED visit or stay longer in an observation unit to receive their first dose of buprenorp…

This study aimed to compare two ways of managing pain after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would receive a lower dose around the time of surgery. The goal was to see which approach better …

This study tests a program called ED-LINC that starts in the emergency room for people with opioid use disorder. The program offers overdose education, motivation to seek help, help choosing medication, and three months of follow-up care. Researchers want to see if this approach …

This study tests a program that connects pregnant women with opioid use disorder to a team of doctors, peer supporters, and community resources like doulas and home visiting. The goal is to improve treatment during pregnancy and reduce the need for medication in newborns experien…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This study tests a program called HEROES that combines medication (Suboxone), counseling, and community outreach to help people with opioid use disorder engage and stay in treatment. Researchers will enroll 3,000 participants in Houston to see if this approach improves treatment …

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study looks at whether a mobile mindfulness app (Headspace) can help people being treated for opioid use disorder who also have a history of childhood trauma. Sixty participants will be asked to use the app daily for 30 days and visit the clinic four times to check stress le…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests whether an adapted version of Cognitive Processing Therapy (CPT), delivered via telehealth at syringe service programs, can reduce PTSD symptoms and help people stay on their opioid use disorder medication. Eleven adults who regularly use syringe services and are…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests a new sublingual film called BXCL501 (dexmedetomidine) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, muscle pain, and nausea. About 160 adults with opioid use disorder will receive the drug, a placebo, or an existing medication (lofexidine…

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study aimed to compare two pain medicines given into the spinal fluid during C-section for patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery. However, the trial was withdrawn before any pa…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study tests a device called NET that uses mild electrical stimulation to reduce opioid withdrawal symptoms. It involves 108 adults who want to stop using opioids without taking other medications. Participants are randomly assigned to get real or sham device treatment, and re…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

Researchers at UC San Diego want to know whether doing a mental task changes breathing differently in people who take opioid pain medicine every day, people with obstructive sleep apnea, and healthy adults. The study compares three groups of 40 adults in total. Each participant v…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study develops and tests a computer tool that helps pharmacists screen patients for opioid medication risks. Researchers will compare pharmacies using the tool to those using standard care. The goal is to see if the tool lowers patients' risk of opioid abuse.

This observational study follows pregnant women with opioid use disorder who are taking buprenorphine or methadone. Researchers use MRI scans of the placenta and fetal brain during the second and third trimesters, along with blood samples and developmental assessments after birth…

This study tests whether a coaching program called COSTARS helps child welfare supervisors better support their teams, including caseworkers and peer mentors with lived recovery experience. About 200 supervisors in Ohio's START program will either receive coaching or continue usu…

This study aims to validate two new tools that use artificial intelligence to predict a person's risk of developing opioid use disorder. One tool looks at genetic markers, and the other examines gut bacteria. Researchers will enroll 300 adults with or without opioid addiction to …

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study follows adults who have knee replacement surgery using a fast-track recovery program called ERAS. Researchers want to know how many people still have pain three months later, how severe it is, and whether they still need strong painkillers. Participants answer simple q…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study looks at whether a mobile peer support app can help people who have been in jail or prison and are recovering from opioid use disorder feel more connected and less lonely. About 90 adults who recently took medication for opioid use disorder while incarcerated will use …

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This pilot study will use special PET scans to measure opioid receptor binding in the brain, spinal cord, and other organs in up to 60 adults, including healthy volunteers and people with opioid use disorder. The goal is to better understand how opioids affect the whole body, not…

This study tests whether a job coaching program called Individual Placement and Support (IPS) helps veterans with opioid use disorder find and keep competitive jobs. Researchers will compare IPS to standard vocational rehab in 123 veterans. They also want to see if getting a job …

This study tests a training program called PATH, designed to help peer recovery support specialists who deliver harm reduction services. The program includes online lessons and group meetings to discuss real-life cases. Researchers want to see if it reduces burnout and improves t…

This study tests whether an online support program called HOPE can help people with opioid use disorder ask for medication treatment. Researchers will assign 640 participants to either the HOPE online community or a control group and track how many request information about medic…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll 30 patients and 5-10 staff, giving patients the combined injections and following up …

This study tests whether giving doctors brief education and feedback on their opioid prescribing habits leads to safer prescribing. About 52 primary care clinics are involved. The goal is to reduce inappropriate opioid use and lower the risk of addiction.

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…

This study is developing and testing a mobile app to teach pregnant women with opioid use disorder how to care for newborns who may experience neonatal abstinence syndrome (NAS). The app provides training on comforting techniques like swaddling, skin-to-skin contact, and feeding.…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with opioid use disorder stick with their methadone treatment and avoid relapse. Researchers will measure how stress affects cravings and decision-making. 32 adults currently in methad…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study involves 3,650 adults in 20 opioid treatment programs who are starting medication for opioid use disorder. Participants will use digital tools to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treat…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…

This study follows 400 adults receiving standard treatment for prescription narcotic drug use disorder, including opioids and benzodiazepines. Researchers will measure how many patients reduce or stop using these drugs and what factors help. No new treatments are tested; the goal…