Essential tremor

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This study is collecting information from 500 people with essential tremor who are using a Boston Scientific deep brain stimulation (DBS) system, which is already approved for use. The goal is to see how the device affects quality of life in real-world settings, not just in contr…

This study tests whether using 3-D tractography—a detailed brain imaging method—can make focused ultrasound ablation safer and more effective for people with essential tremor. Twenty-four adults with moderate to severe tremor that hasn't responded to medication will receive the p…

This study is testing deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve enough with medication. DBS uses a device like a pacemaker to send electrical pulses to specific brain areas that control movement. R…

This study tests whether a second focused ultrasound treatment on the opposite side of the brain can further reduce tremors in people with essential tremor who already had one treatment. About 100 participants will be randomly assigned to get the second procedure or continue stan…

This study tests whether electrical stimulation of a part of the brain called the deep cerebellar nuclei can safely reduce severe tremor. The participants are adults with essential tremor, cerebellar outflow tremor, or MS-related tremor that has not improved with medication or pr…

This study tests whether adding a substance called hyaluronan to the liquid used during embryo transfer can improve pregnancy rates in IVF. Researchers will compare live birth rates between women whose embryos are placed in a hyaluronan-rich medium versus a standard one. The tria…

This study tests a new type of brain implant with two leads to better control severe essential tremor in 10 adults who already have a standard implant. The goal is to see if this approach improves tremor control and can lead to a smarter, adaptive system. This is an early feasibi…

This international study is following 1,000 people who already have or are getting an Abbott deep brain stimulation (DBS) system to treat Parkinson's disease, essential tremor, or dystonia. Researchers will track how well the device controls symptoms and monitor for serious side …

This study tracks 240 adults with essential tremor that doesn't improve with medication. They will receive a non-invasive procedure called MR-guided focused ultrasound, which uses sound waves to target the brain area causing tremors. Researchers will check if tremor control lasts…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study follows 60 people with essential tremor or Parkinson's tremor whose symptoms aren't well-controlled by medication. After receiving stereotactic radiosurgery—a precise dose of radiation to a small brain area—participants fill out questionnaires about their quality of li…

Researchers are testing whether people with Parkinson's disease, epilepsy, or essential tremor can use visual neurofeedback to change abnormal brain activity linked to their symptoms. Participants already scheduled for deep brain stimulation surgery use their implanted electrodes…

This trial is testing a wearable device that delivers gentle electrical stimulation to the skin to help reduce tremors in people with essential tremor, a condition that causes shaking and can make daily tasks difficult. The study will follow about 50 adults over time to see if th…

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS runs all the time, which can cause side effects and make the treatment less effective over time. The researchers will program the device to automatically turn off when you are aslee…

This study tests an investigational drug called gemibotulinumtoxinA (a type of botulinum toxin) injected into arm muscles to reduce tremor in adults with essential tremor. About 94 participants will receive either the drug or a placebo injection. Researchers will measure changes …

This study tests a new way to deliver deep brain stimulation (DBS) for essential tremor, called coordinated reset DBS. Instead of constant high-frequency pulses, it uses lower-current patterns that may work better and have fewer downsides. About 23 adults with essential tremor wh…

This early-phase study tests whether low-intensity focused ultrasound (LIFU) can safely reduce tremors in people with essential tremor. Twenty adults will receive six non-invasive ultrasound sessions targeting a small brain area involved in movement. Researchers will measure trem…

This study tests whether transcranial magnetic stimulation (TMS) timed to a person's own tremor cycle can reduce shaking in Essential Tremor and Parkinson's disease. Twenty participants with each condition will receive TMS pulses over the motor cortex while their tremor is record…

This study is testing a device called ViBandz, which uses small vibrating motors strapped to the body to provide vibration therapy. Researchers want to see if it is easy and comfortable for children with neurological conditions to use at home. The study will involve 30 children a…

This study tests whether low-intensity focused ultrasound (LIFU) can temporarily reduce essential tremor by targeting specific brain areas. Sixty people scheduled for a standard ultrasound procedure will receive up to 25 short ultrasound pulses while researchers measure tremor ch…

This study tests a new way to treat essential tremor, a condition that causes uncontrollable shaking during everyday tasks like writing or holding a cup. Instead of targeting just one brain area, researchers will stimulate two key regions—the supplementary motor area and the cere…

This study looks at whether watching a virtual reality (VR) video can lower anxiety in people about to undergo a brain procedure (MRgFUS) for severe hand tremors. About 60 adults will be randomly assigned to watch one of two VR videos before their treatment. Researchers will meas…

This study tests if a new drug called BP1.4979 can reduce tremors in adults with essential tremor, a condition causing uncontrollable shaking. About 50 participants will take either the drug or a placebo twice daily for 4 weeks. Researchers will check tremor severity and safety t…

This study is testing a wristband that delivers gentle, personalized vibrations to the wrist to help reduce hand tremors in people with essential tremor or Parkinson's disease. About 80 participants will use the device at home over several weeks. The goal is to see if the device …

This study tests a newer type of deep brain stimulation (DBS) that aims to control essential tremor while causing fewer problems with speech, walking, and balance. About 24 adults with hand tremors for at least 3 years will receive both directional and standard DBS to compare whi…

This early study tests whether gentle ultrasound waves aimed at a deep brain area can safely reduce hand tremors. It will include 12 people with Parkinson's, essential tremor, or dystonic tremor who haven't gotten enough relief from medication. The main goal is to check safety, b…

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This study aims to understand the link between genes and symptoms in people with inherited movement disorders. Researchers will study up to 2,500 participants, including patients and their family members, to identify new disease-causing genes and improve diagnosis. The goal is to…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study is testing whether a skin biopsy can detect abnormal proteins linked to Parkinson's disease in people with essential tremor, a common movement disorder. Researchers will follow 300 participants aged 50-85 for two years to see who develops Parkinson's. The goal is to fi…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive radiofrequency (RF) ablation—a procedure that uses heat to target small areas in the brain. The goal is to see how p…

This study reviews the medical records of up to 5,000 people who have received deep brain stimulation (DBS) for Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in real-world settings. No new treatments are given…

This study follows 600 people with neurodegenerative diseases such as Parkinson's, Alzheimer's, and related conditions over 1 to 10 years. Researchers collect data from routine clinical exams, brain imaging, movement analysis, and blood tests. They use statistical tools and artif…

This study aims to build a comprehensive 'physiological brain atlas' by collecting electrical and other data from patients undergoing stereotactic brain surgery for conditions like Parkinson's disease, OCD, and epilepsy. The goal is to map this information onto a standard brain t…

This study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study investigates how deep brain stimulation (DBS) and medication alter the brain networks that control movement in people with Parkinson's disease or essential tremor. During awake DBS surgery, researchers will record electrical activity from the brain's surface and deep s…

This study records brain activity from people with movement disorders like Parkinson's disease, essential tremor, and dystonia. Researchers use scalp electrodes or existing deep brain stimulators to measure electrical signals. The goal is to find patterns linked to symptoms, whic…

This study looks at children in Vietnam who have movement disorders—like tremors, jerks, or coordination problems—with no known cause. Researchers will collect medical information and blood samples to search for genetic changes that might explain these conditions. The goal is to …

This study looks at how deep brain stimulation (DBS) affects brain activity in people with essential tremor. Researchers will use EEG and MEG to record brain signals with the stimulator on and off, and also test other tremor-relief methods like cooling or medication. The goal is …

This study looks at how deep brain stimulation (DBS) changes attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, durin…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) changes brain activity in people with essential tremor (shaking hands). Ten adults over 50 who haven't been helped by standard medications will have their brain waves recorded before and after tre…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during speech tasks while participants undergo deep brain stimulation (DBS) surgery. The study does not test…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory loss or depre…

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study looks at whether a brain treatment called focused ultrasound can reduce the social stigma that people with essential tremor often face. About 220 adults with essential tremor will have their tremor treated and then be followed for one year. Researchers want to see if l…

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. Researchers will create personalized brain models to predict which stimulation settings work best and cause fewer side effects. The g…

This study aims to translate the Hypertonia Assessment Tool (HAT) into Turkish and check if it works correctly. The HAT helps doctors identify different types of increased muscle tone in children with motor disorders. Researchers will test the tool on 70 children under 18 who hav…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants…

This study uses brain scans (fMRI, MEG, EEG) and a numbing throat spray to understand what goes wrong in the brains of people with laryngeal dystonia or voice tremor. Researchers will compare brain activity between these groups and healthy volunteers. The goal is to find unique b…

This pilot study is testing whether virtual reality motor tasks can help understand functional tremor, a type of movement disorder. Researchers will measure reaction time and brain activity in 48 people with functional tremor, essential tremor, or healthy controls. The goal is to…