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Brain implant study reveals how Parkinson's changes social cues

NCT ID NCT06899022

Knowledge-focused Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how deep brain stimulation (DBS) changes attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, during, and after DBS surgery. The goal is to understand how DBS affects social perception and whether it can be adjusted to improve attention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 138 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * All Participants (Aim 1): * Ability and willingness to provide signed informed consent for this study * Ability to express perceptual judgments through a button press or mouse- controlled computerized slider * Age 19 - 90 years * DBS Participants (Aim 1): * Diagnosis of idiopathic Parkinson's disease (PD), essential tremor (ET) or dystonia (DT). * Scheduled for new implantation of a therapeutic DBS device targeted to subthalamic nucleus (STN), ventral intermediate nucleus of thalamus (VIM) or internal globus pallidus (GPi) * Comparison Participants (Aim 1): o Selection by age matching to participants in PD group * Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 2): * Ability and willingness to provide signed informed consent for this study * Ability to express perceptual judgments through a button press or mouse- controlled computerized slider * Age 19 - 90 years * Scheduled for awake DBS implantation with clinical micro-electrode recordings (MER) * Willing and able to engage in tasks during an awake surgical procedure * Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 3): * Ability and willingness to provide signed informed consent for this study * Ability to express perceptual judgments through a button press or mouse- controlled computerized slider * Age 19 - 90 years * Willing to undergo acute manipulations of DBS * Able to tolerate acute changes of DBS Exclusion Criteria * All Participants (Aim 1): * Corrected visual acuity insufficient to perceptually judge face stimuli * Inability to understand task instructions or complete task requirements * DBS Participants (Aim 1): o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control a slider * Healthy Comparison Participants (Aim 1): o History of neurodegenerative disorder * Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 2): * Corrected visual acuity insufficient to perceptually judge face stimuli * Inability to understand task instructions or complete task requirements * Not undergoing awake DBS implantation * Uncorrected visual acuity insufficient to perceptually judge face stimuli * Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 3): * Corrected visual acuity insufficient to perceptually judge face stimuli * Inability to understand task instructions or complete task requirements * Failure of DBS to achieve a therapeutic effect on motor symptoms

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Conditions

The condition(s) this trial relates to.

dystonic disorder essential tremor Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dystonias Essential tremor Parkinson'S disease (PD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.