Chronic apical periodontitis

This trial compares root canal treatments using one, two, three, or four rotary files to see if the number of instruments affects how well dentists can reach a tricky second canal in upper molars and how much pain patients feel afterward. Adults with asymptomatic apical periodont…

This trial tests whether photoactivated disinfection (using a light-activated dye) or Er,Cr:YSGG laser disinfection can better clean infected tooth sockets before placing an immediate dental implant, compared to standard chlorhexidine rinsing. The goal is to see which method lead…

This trial compares three treatments for mature teeth with apical periodontitis (infection at the root tip): standard root canal treatment, regenerative endodontic treatment using a blood clot, and regenerative treatment with added bone-growth proteins. The study includes 30 heal…

This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three …

This study tested whether a single dental visit for regenerative root canal treatment works as well as the usual two-visit approach for mature teeth with chronic infection. Thirty-two adults received either a one-session or two-session procedure, and researchers tracked pain duri…

This study looked at whether using a patient's own blood product (L-PRF) can improve bone healing after surgery for a persistent tooth-root infection. Fifteen adults with large infections around the tooth root were treated and followed for 12 months. The goal was to see if adding…

This study tested three different medications placed inside the tooth root after cleaning to see which one works best for reducing pain, fighting bacteria, and helping bone heal. 45 adults with a single infected tooth took part. The medications compared were N-acetylcysteine, cal…

This study tested three ways to clean infected root canals in 97 people with large tooth infections. The methods were manual movement, ultrasonic vibration, and laser activation. Researchers measured how much the infection shrank over one year using 3D scans. The goal was to find…

This study explores whether gas samples from the mouth can be collected and analyzed up to 7 days later to diagnose halitosis (bad breath). Researchers will take breath samples from 100 adults with gum disease and measure volatile sulfur compounds—the molecules responsible for ba…

This study tests an artificial intelligence system that measures the width of keratinized gingiva (a type of gum tissue) from smartphone photos. Researchers will compare the AI's measurements to those made by dental experts to see how accurate the tool is. The goal is to make gum…

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

This trial tests whether a nano-sized form of calcium hydroxide, placed inside the tooth after cleaning, reduces pain following root canal treatment compared to the conventional version. Adults aged 18 to 65 with a dead nerve in a single-rooted tooth and an infection at the tip o…

This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. …

This study tests whether a simple technique called apical patency—passing a tiny file slightly beyond the root tip during root canal treatment—can reduce pain afterward. Adults with an infected front tooth will be randomly assigned to receive treatment with or without this extra …

This study asks whether the phase of the menstrual cycle influences pain and anxiety during a deep dental cleaning in premenopausal women with moderate gum disease. Researchers will compare pain scores and anxiety levels when treatment is done just before or just after menstruati…

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study tested a device called EDDY that uses sound waves to clean root canals better. Forty adults with infected teeth but no pain were treated. The sonic cleaning killed more bacteria than standard methods, but it did not reduce pain after the procedure compared to usual car…

This study looked at 88 healthy adults with infected teeth to see if different irrigation methods during root canal treatment affect pain afterward. Participants had a tooth with a chronic infection and received one of several irrigation techniques. The goal was to find which met…

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and …

This study looked at 70 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if the type of sealer used during root canal treatment affects pain afterward. Participants received either a bioceramic sealer (BioRoot RCS) or a resin-based sealer (AH Plus) …

This study looked at 120 adults needing a root canal to see if one sealer (AH Plus or WellRootST) causes less pain afterward. Pain was checked before treatment and at several points up to one month later. The goal is to help dentists choose the better option for patient comfort.

This study tested whether using 3D-guided microsurgery helps bone heal better after a failed root canal compared to standard surgery. It also compared two different filling materials: a newer bioceramic putty and the standard MTA. Twenty-four adults with persistent infections aft…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PR…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and …

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study looked at whether using a special laser (Nd:YAG) during root canal treatment could help reduce inflammation and oxidative stress in infected teeth. Researchers measured certain markers in fluid samples from 58 patients. The results showed that the laser did not provide…