Tooth infection healing: which irrigation technique wins?
NCT ID NCT06204887
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested three ways to clean infected root canals in 97 people with large tooth infections. The methods were manual movement, ultrasonic vibration, and laser activation. Researchers measured how much the infection shrank over one year using 3D scans. The goal was to find which technique helps the most.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could identify the most effective irrigation technique for healing large tooth infections, improving dental outcomes.
- What could go wrong
- This is a completed trial with 97 participants, so results are available but may not apply to all patients or tooth types. The study is small and focused on specific teeth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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97 people
The number who actually took part.
- Started
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Nov 2021
- Finished
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May 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients having single root mandibular teeth * Patients the diagnosis of chronic apical periodontitis, * Periapical index score of 3 and above, * Patients having good oral hygiene Exclusion Criteria: * Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders), * Patients with bone metabolism disease and/or * Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates) * Patients with a history of radiotherapy * Pregnant patients * Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Recep Tayyip Erdogan University
Rize, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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