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Which root canal filler hurts less? new study has answers

NCT ID NCT07289633

Symptom relief Sponsor: AZİZ ŞAHİN ERDOĞAN Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 70 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if the type of sealer used during root canal treatment affects pain afterward. Participants received either a bioceramic sealer (BioRoot RCS) or a resin-based sealer (AH Plus) in a single visit. Pain was measured at 24 hours, 48 hours, 72 hours, and 7 days after treatment to find which sealer leads to less discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Mar 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years or older with adequate oral hygiene. * Teeth with no previous endodontic or restorative treatment. * Teeth that do not respond to cold test and electric pulp test during vitality assessment. * Teeth that are asymptomatic prior to treatment. * Mandibular first or second molar teeth with complete root development. * No bleeding observed in the pulp chamber after caries removal. * Teeth with a Periapical Index (PAI) score of 3 or less. * Patients who have not used antibiotics within the last 1 month. * Patients who have not used analgesics within the last 72 hours. Exclusion Criteria: * Presence of systemic diseases that may affect healing (e.g., uncontrolled diabetes, immunosuppression). * Pregnancy or breastfeeding. * Teeth with a history of trauma, resorption, or previous endodontic access. * Teeth with root canal calcifications or anatomical abnormalities preventing standard instrumentation. * Presence of sinus tract, swelling, or acute apical abscess. * Teeth with a Periapical Index (PAI) score greater than 3. * Patients taking medications that may alter pain perception (e.g., corticosteroids, neuropathic pain medications). * Patients unable to comply with follow-up pain recordings. * Patients with known allergy to any materials used in the study (e.g., sodium hypochlorite, sealers).

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis

Contacts and locations

Locations

  • Atatürk University Faculty of Dentistry

    Erzurum, palandöken, 25100, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.