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Tooth infection showdown: which paste stops pain best?

NCT ID NCT07340944

Disease control Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three different medications placed inside the tooth root after cleaning to see which one works best for reducing pain, fighting bacteria, and helping bone heal. 45 adults with a single infected tooth took part. The medications compared were N-acetylcysteine, calcium hydroxide, and a double antibiotic paste.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Sep 2022

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-vital teeth confirmed by clinical and pulp sensitivity tests * Teeth with a single canal and diagnosed with asymptomatic apical periodontitis * Periapical assessment (PAI) of 2 or greater * Teeth with a pocket depth not exceeding 3 mm * Teeth without excessive root curvature (Schneider class 1) and with visible root canals on radiographs * Permanent teeth with complete root development * Patients between the ages of 18 and 65 * Teeth without previous endodontic treatment Exclusion Criteria: * Patients who refused to participate in the study * Patients with any systemic disease * Patients who received antibiotic treatment within the last 3 months * Patients who were pregnant or suspected of being pregnant * Teeth with excessive crown damage that would not allow for the placement of a rubber dam * Teeth with root fractures, pathological findings or mobility, * Presence of any resorption in the involved tooth, * Patients with active swelling and tenderness to palpation.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis

Contacts and locations

Locations

  • Ataturk University

    Erzurum, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.