Acute myocardial infarction

Researchers are studying the SPIKE FLOW endocardial lead, a temporary wire placed inside the heart to keep it beating during surgery or while doctors check a slow heart rhythm. The study enrolls 131 adults who need short-term cardiac pacing. Doctors implant the lead, measure how …

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study tests whether quickly upgrading from a standard heart pump (Impella CP) to a more powerful one (Impella 5.5) within 24 hours after a heart attack improves outcomes for people in cardiogenic shock. The trial will enroll 115 adults aged 18-77 who have had a heart attack …

This trial compares two ways to access the blood vessels during cardiac catheterization: through the wrist (radial access) versus through the groin using modern techniques (femoral access). The goal is to see which approach leads to fewer bleeding events and access-site complicat…

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This study looks at the best timing for opening blocked arteries in people having a certain type of heart attack (NSTEMI) who have multiple blockages. About 1,014 participants will be randomly assigned to have all blockages fixed during the same procedure or to wait a few days be…

This early study is testing a new heart pump device (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The device is inserted through a blood vessel to help the heart pump. Researchers are checking if it is…

This study looks at whether heart attack patients with mild artery narrowing can be treated with medication alone instead of getting a stent. About 2,000 people will be randomly assigned to either standard medication or medication plus a stent. The goal is to see if medication al…

This study compares a new drug, Zastaprazan, against standard proton pump inhibitors (PPIs) for preventing stomach bleeding in 5,000 adults who had a heart attack and are on blood thinners. The goal is to see if routine use of Zastaprazan reduces serious complications like death,…

This study tests whether montelukast, a common asthma drug, can reduce inflammation and limit heart muscle damage in people who have just had a heart attack. Eighty adults aged 30-75 will receive either montelukast or a placebo for 4 weeks. Researchers will measure changes in blo…

This study looks at whether using aspirin alone is as effective and safer than aspirin plus another blood thinner (fondaparinux) before a heart procedure in people with a type of heart attack called NSTEMI. About 5,000 participants will be randomly assigned to one of the two trea…

This study looks at two ways to treat blocked heart arteries in people aged 18 to 68. One uses a drug-coated balloon, and the other uses a temporary scaffold. The goal is to see which approach works better over time, with fewer heart problems or need for repeat procedures. About …

This study tests whether giving the drug adenosine just before emergency angioplasty (PCI) can improve blood flow in heart attack patients. About 1,148 adults having a severe type of heart attack (STEMI) will either receive adenosine or standard care. The goal is to see if adenos…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study tests whether the drug deferiprone can safely reduce harmful iron buildup in the heart after a severe heart attack. About 89 adults with a specific type of heart attack will receive either deferiprone or a placebo for 6 months. The goal is to see if lowering iron level…

This study tests whether getting a flu vaccine soon after a heart attack can reduce inflammation in the heart's arteries. Researchers will compare the vaccine to a placebo in 90 adults who recently had a heart attack and a stent procedure. They will use special CT scans and blood…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This trial tests whether doing a coronary angiogram (a special X-ray of the heart arteries) within 2 hours of diagnosis is better than waiting until the patient's heart failure symptoms improve. The study includes 780 adults with a type of heart attack called NSTEMI who also have…

This trial tests whether eplerenone, a drug used for high blood pressure and heart failure, can help people who have had a heart attack or heart injury but no blocked arteries. Many of these patients have damage to tiny blood vessels in the heart. The study will involve 400 adult…

This study tests whether a new medicine called ziltivekimab can reduce fatty plaque buildup in heart arteries after a heart attack. About 332 participants will receive either the drug or a placebo for 15 months. The goal is to see if the drug helps control artery disease and prev…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This study looks at how different types of aerobic exercise affect blood vessel health in people with ischemic heart disease (such as after a heart attack or angina). Researchers will compare high-intensity interval training with short bursts, long bursts, and moderate-intensity …

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study follows 100 people who received Hearticellgram-AMI, a stem cell treatment for acute heart attacks, to see if any serious side effects appear years later. Researchers are watching for death, new cancers, or immune reactions. The goal is to confirm the treatment's long-t…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early in the hospital, right after a heart attack, can reduce the chance of another heart attack, stroke, or death over the next year. About 1,500 adults with multiple blocked arteries wil…

This study looks at whether giving a PCSK9 inhibitor (alirocumab) soon after a heart attack can help save more heart muscle. About 160 adults having a specific type of heart attack will either get the drug or standard care. The main goal is to see if the drug improves heart muscl…

This study looks at whether a genetic test can help choose a safer blood thinner for people who have had a heart attack. After one month on two blood thinners, some patients will switch to a single, lower-potency drug based on their genetic profile. The goal is to see if this app…

This study tests two diabetes medications (SGLT2 inhibitors and GLP-1 agonists) to see if they can reduce epicardial fat—the fat around the heart—in people who recently had a heart attack. About 136 participants with type 2 diabetes and obesity will have their heart fat measured …

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study looks at whether people who have had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either continue or stop their beta-blocker medication. The goal is to see if …

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study tests whether a single injection of morphine around certain neck nerves can reduce heart muscle damage after a heart attack. About 166 adults who have had a severe heart attack and undergone artery-opening treatment will receive either morphine or a saltwater placebo. …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests a new way to use blood thinners after a heart attack. The goal is to lower the risk of serious bleeding while still preventing another heart attack or stroke. About 2,300 adults who had a heart attack and received a stent will take part. Half will get a reduced d…

This study is testing whether a simple, non-drug procedure called remote ischemic preconditioning (RIPC) can help people recover better after a heart attack. RIPC involves briefly inflating a blood pressure cuff on the arm or leg to restrict blood flow, then releasing it, repeate…

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

Researchers are testing a noninvasive wearable sensor patch that uses near-infrared light to continuously measure tissue oxygen and blood flow in people hospitalized with cardiogenic shock after a heart attack or heart failure. Up to 20 adults in a cardiac intensive care unit wea…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study tests whether an AI tool that reads ECGs can safely and effectively help emergency doctors decide if a patient with chest pain is having a heart attack. About 4,670 adults with chest pain suspicious for a heart attack will be randomly assigned to either AI-assisted or …

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study is testing a new way to analyze blood samples to see if it can better tell when someone is having a heart attack. Current tests can be misleading in patients with other conditions like kidney failure. Researchers will look at how troponin T, a protein released during h…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

Researchers at Al-Kadhimiya Teaching Hospital in Baghdad are studying how delays before and during hospital care affect outcomes for people who have a heart attack. The study follows 200 patients who receive reperfusion therapy, such as clot-busting drugs or angioplasty, within 1…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This study tests whether artificial intelligence can use continuous ECG data to predict and detect life-threatening heart arrhythmias in patients admitted with acute cardiac illness. Researchers will analyze stored ECG data from 3000 adult patients to see if AI models can forecas…

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergo…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study looks at whether combining a new type of CT scan with a blood test for tiny molecules called microRNAs can better predict heart damage after a heart attack. Researchers will follow 95 patients who had a severe heart attack and measure changes in their heart size over s…

This study explores whether a special PET/MR scan can detect early signs of heart muscle damage after a heart attack. Researchers will scan 25 adults about 10 days after their heart attack and then track their heart function with MRI scans at 3 and 6 months. The goal is to see if…

This study observes up to 350 patients who had a heart attack complicated by cardiogenic shock and received an Impella CP heart pump during artery-opening procedures. Researchers will track safety issues like major bleeding, limb problems, and kidney injury, as well as survival a…

This study is a registry that collects information from all suspected heart attack cases in Tomsk, Russia. It aims to track how many people die within 28 days and one year after a heart attack. No new treatments or drugs are being tested—just observation and data gathering.

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

After a heart attack, patients face a high risk of dangerous heart rhythms, but current monitoring methods may miss them. This trial tests whether a small implantable cardiac monitor (ICM) placed under the skin can catch these rhythms earlier and help doctors adjust treatment. Tw…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This study is testing whether a detailed CT scan of the heart and arteries can better predict future heart attacks, heart failure, or dangerous heart rhythms in people who have already had a heart attack and a stent placed. Researchers will follow 1,000 patients for up to five ye…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study tracks 774 adults who develop a new type of irregular heartbeat (atrial fibrillation) while hospitalized for a heart attack. Researchers will use continuous electronic monitoring to measure how much time patients spend in this abnormal rhythm. The goal is to see if the…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether people who have a heart attack can be discharged from the hospital after about 24 hours instead of the usual 36 hours or more. Researchers want to see if early discharge is just as safe and does not increase the risk of death, another heart attack, or …

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study tests whether a special nurse-led education program helps people who have had a heart attack feel more confident managing their health. Participants will either receive standard care or extra support including personalized advice on diet, exercise, and quitting smoking…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during a standard procedure…

This study follows 314 women under 50 who had a heart attack in France. Researchers will track their health, stress, anxiety, and quality of life over several years. The goal is to learn more about long-term risks and recovery, not to test a new treatment.

This registry is following 5,000 people who had a heart attack and were treated with medications, stents, or bypass surgery at Asan Medical Center in Korea. Researchers are tracking deaths, repeat heart attacks, and other major events over the long term to understand which treatm…

This study looks at whether people having urgent heart catheterization need to fast beforehand. 400 patients with chest pain or mild heart attacks will be randomly assigned to either fast as usual or eat and drink normally. Researchers will measure comfort and safety to see if sk…

This study looks at 1,600 people who recently had a heart attack to see if a common blood test (the neutrophil-to-lymphocyte ratio, or NLR) can help predict who is at higher risk of dying or having another heart problem within 6 months. Researchers will measure NLR from blood sam…

This study follows 15,000 people who survived a heart attack and were part of an earlier project. Researchers will call participants at 3 and 5 years after leaving the hospital to check their health, medications, and whether they had any major heart problems like another heart at…